This disclosure provides improved lipid-based compositions, including lipid nanoparticle compositions, and methods of use thereof for delivering agents in vivo including nucleic acids and proteins. These compositions are not subject to accelerated blood clearance and they have an improved toxicity profile in vivo.
This disclosure provides improved lipid-based compositions, including lipid nanoparticle compositions, and methods of use thereof for delivering agents in vivo including nucleic acids and proteins. These compositions are not subject to accelerated blood clearance and they have an improved toxicity profile in vivo.
- Cambridge MA, US Stephen Hoge - Brookline MA, US Joseph Senn - Cambridge MA, US Kerry Benenato - Sudbury MA, US Staci Sabnis - Cambridge MA, US
Assignee:
ModernaTX, Inc. - Cambridge MA
International Classification:
A61K 48/00 A61K 47/69 A61K 47/60 A61K 47/54
Abstract:
This disclosure provides improved lipid-based compositions, including lipid nanoparticle compositions, and methods of use thereof for delivering agents in vivo including nucleic acids and proteins. These compositions are not subject to accelerated blood clearance and they have an improved toxicity profile in vivo.
This disclosure provides improved lipid-based compositions, including lipid nanoparticle compositions, and methods of use thereof for delivering agents in vivo including nucleic acids and proteins. These compositions are not subject to accelerated blood clearance and they have an improved toxicity profile in vivo.
Dianne Hausman, James Corrigan, Barry Coughlin, Charles Smith, Richard Sylvia, Jack Boyd, James Gleason, Leo Connerton, Thomas Foley, Dave Piper, George Sullivan
Pat Twiner, Clarisse Haase, Donith Fairchild, Catherine Hurston, Michael Leblanc, John Hymel, Gloria Martin, Robert Berggreen, Joseph Brown, Dorthey Minsker, Mary Berggreen
Joseph Senn (1951-1955), Dustin Lowery (1988-1992), Mary Gilfoil (1979-1983), Charles Joyner (1948-1952), Billy Wilson (1954-1958), Jeannie Reece (1984-1988)