Joseph J Hlavka

US Patent:

6506740, Jan 14, 2003

Filed:

May 18, 2000

Appl. No.:

09/573654

Inventors:

Robert A. Ashley - Newtown PA 18940
Joseph J. Hlavka - Tuxedo Park NY 10987

International Classification:

A61K 3165

US Classification:

514152, 552205

Abstract:

The present invention provides new chemically modified 4-dedimethylaminotetracycline compounds that can be substituted at the 7, 8, and/or 9 positions and methods for preparing the 4-dedimethylamino tetracycline compounds. Other tetracycline compounds are the 4-dedimethylaminotetracycline derivatives with an oxime group, NH-Alkyl, or NâNH-Alkyl group at the C4 position. The present invention also provides a method of treating a mammal suffering from conditions or diseases by administering to the mammal an effective amount of the new chemically modified 4-dedimethylamino tetracycline compounds.

US Patent:

6638922, Oct 28, 2003

Filed:

Jul 24, 2001

Appl. No.:

09/911861

Inventors:

Robert Ashley - Newton PA
Joseph J. Hlavka - Suffern NY

Assignee:

CollaGenex Pharmaceuticals Incorporated - Newtown PA

International Classification:

A61K 3165

US Classification:

514152, 552203

Abstract:

The present invention provides new chemically modified 4-dedimethylaminotetracycline compounds that can be substituted with aryl, alkenyl, or alkynyl groups. The 7, 8, and/or 9 positions and methods for preparing such compounds. Other tetracycline compounds include the 4-dedimethylaminotetracycline derivatives with an oxime group, NH-Alkyl, or NâNH-Alkyl group substituted at the C4 position as well as C2 Mannich derivatives. The present invention also provides a method of treating a mammal suffering from conditions or diseases by administering to the mammal an effective amount of the new chemically modified tetracycline compounds.

US Patent:

6767897, Jul 27, 2004

Filed:

Apr 11, 2002

Appl. No.:

10/122246

Inventors:

Henry B. Abajian - Hillsdale NJ
Joseph J. Hlavka - Tuxedo Park NY
John P. Feighner - La Jolla CA

Assignee:

Innapharma, Inc. - Park Ridge NJ

International Classification:

A61K 3808

US Classification:

514 17, 530330

Abstract:

Novel uses of certain peptides to treat patients suffering from neurological or psychiatric disorders are disclosed. The peptides include the tripeptide hormone MIF and compounds made by modifications of MIF, such as modification of amino terminus residues, carboxyl terminus residues and internal residues, including addition and substitution of amino acid residues and modification of the peptide bonds and functional side groups of respective amino acid residues. The tri-, tetra-, penta-, peptides and polypeptides may be utilized alone or in combination with other agents, to treat patients suffering from physiological, psychosomatic, neurological or psychiatric disorders.

US Patent:

7214669, May 8, 2007

Filed:

Oct 4, 2002

Appl. No.:

10/264454

Inventors:

Joseph J. Hlavka - Tuxedo Park NY, US
Richard J. Ablin - Ringwood NJ, US

Assignee:

Tetragenex Pharmaceuticals, Inc. - Park Ridge NJ

International Classification:

A61K 31/65
C07C 237/26

US Classification:

514152, 552203, 552205, 552206

Abstract:

A treatment for inhibiting microbial or tumor growth is disclosed, which comprises adding to a subject in need of treatment an effective amount of one or more tetracycline derivatives.

US Patent:

RE40086, Feb 19, 2008

Filed:

Dec 23, 2005

Appl. No.:

11/318390

Inventors:

Joseph J. Hlavka - Tuxedo Park NY, US
Yakov Gluzman - Upper Saddle River NJ, US
Ving J. Lee - Los Altos CA, US
Adma A. Ross - Airmont NY, US

Assignee:

Wyeth Holdings Corporation - Madison NJ

International Classification:

A61K 31/65

US Classification:

514152

Abstract:

The disclosure is drawn to a method of using novel 7-substituted-9-(substituted amino)-6-demethyl-6-deoxytetracycline compounds to treat infections caused by a wide spectrum of bacterial organisms, including those which are resistant to tetracycline.

US Patent:

RE40183, Mar 25, 2008

Filed:

Jun 3, 2005

Appl. No.:

11/145508

Inventors:

Joseph J. Hlavka - Tuxedo Park NY, US
Yakov Gluzman - Upper Saddle River NJ, US
Ving J. Lee - Los Altos CA, US
Adma A. Ross - Airmont NY, US

Assignee:

Wyeth Holdings Corporation - Madison NJ

International Classification:

A61K 31/65
C07C 233/64

US Classification:

514152, 540200, 544154, 546195, 5482632, 5482676, 548538, 5483164, 5483004, 5483565, 549487, 552203, 552205

Abstract:

The invention is drawn to 7-substituted-9-(substituted amino)-6-demethyl-6-deoxytetracycline compounds of the formula wherein R, X, Rand Rare defined in the specification. The compounds of the invention are useful as broad spectrum antibiotics.

US Patent:

20030195174, Oct 16, 2003

Filed:

Oct 18, 2002

Appl. No.:

10/274841

Inventors:

Robert Ashley - Newtown PA, US
Joseph Hlavka - Tuxedo Park NY, US

International Classification:

A61K031/65
C07C237/26

US Classification:

514/152000, 552/204000

Abstract:

The present invention provides new chemically modified 4-dedimethylaminotetracycline compounds that can be substituted with aryl, alkenyl, or alkynyl groups. The 7, 8, and/or 9 positions and methods for preparing such compounds. Other tetracycline compounds include the 4-dedimethylaminotetracycline derivatives with an oxime group, NH-Alkyl, or N—NH-Alkyl group substituted at the C4 position as well as C2 Mannich derivatives. The present invention also provides a method of treating a mammal suffering from conditions or diseases by administering to the mammal an effective amount of the new chemically modified tetracycline compounds.

US Patent:

20050267079, Dec 1, 2005

Filed:

Mar 9, 2005

Appl. No.:

11/076276

Inventors:

Joseph Hlavka - Tuxedo Park NY, US
Richard Ablin - Ringwood NJ, US

International Classification:

A61K031/65

US Classification:

514152000

Abstract:

A treatment for inhibiting microbial or tumor growth is disclosed, which comprises adding to a subject in need of treatment an effective amount of one or more tetracycline derivatives.