Jerome Mendeleyev

US Patent:

7405227, Jul 29, 2008

Filed:

Jul 18, 2006

Appl. No.:

11/458379

Inventors:

Ernest Kun - Mill Valley CA, US
Jerome Mendeleyev - San Francisco CA, US
Valeria Ossovskaya - San Francisco CA, US

Assignee:

BiPAr Sciences, Inc. - Brisbane CA

International Classification:

A01N 43/42
A01N 43/16
C07D 217/22
C07D 311/02

US Classification:

514309, 514456, 546141, 549287

Abstract:

Methods of treating ovarian cancer, endometrium cancer, cervical cancer, pancreatic cancer, bladder cancer, eve cancer, central nervous system cancer, thyroid cancer and lung cancer are disclosed. Specifically disclosed are methods of treating ovarian adenocarcinoma that has migrated into the abdominal cavity, a transitional cell carcinoma of the bladder, an epithelioid carcinoma in a pancreatic duct, an adenocarcinoma in a pancreatic duct, an adenocarcinoma in the cervical epithelium. The methods comprise administering to a patient a therapeutically effective amount of a compound of formula (Ia).

US Patent:

8377985, Feb 19, 2013

Filed:

Jun 30, 2008

Appl. No.:

12/165437

Inventors:

Jerome Mendeleyev - San Francisco CA, US
Valeria S. Ossovskaya - San Francisco CA, US

Assignee:

BiPar Sciences, Inc. - Bridgewater NJ

International Classification:

A61K 31/47
A61K 31/165
A61K 31/195

US Classification:

514457, 514619, 514562

Abstract:

Methods of treating bone cancer are disclosed. The methods comprise administering to a patient a therapeutically effective amount of a compound of formula (Ia).

US Patent:

20070015814, Jan 18, 2007

Filed:

Jun 12, 2006

Appl. No.:

11/423685

Inventors:

Ernest Kun - Mill Valley CA, US
Jerome Mendeleyev - San Francisco CA, US
Pal Bauer - Budapest, HU

International Classification:

A61K 31/404
A61K 31/366

US Classification:

514415000, 514419000, 514457000

Abstract:

The invention relates to a method of modulating poly(ADP-ribose)polymerase-1 (PARP-1) activity in a mammal comprising administering to a mammal an effective amount of an organic aromatic compound having from 4 to about 35 carbon atoms, wherein said organic aromatic compound is capable of binding the arginine-34 moiety located in Zinc finger-1 of the PARP-1 enzyme and wherein said organic aromatic compound has electron donating capabilities such that it's π-electron system will interact with the positively charged (cationic) guanidinium moiety of the specific arginine-34 residue of the Zinc-1 finger of PARP-1 and does not contain benzamide or lactam substituents. In particular, substituted benzopyrones and substituted indoles and their pharmaceutical compositions containing such compounds that modulate the activity of PARP-1, are described. The invention is also directed to the composition of matter, kits and methods for their therapeutic and/or prophylactic use in treating diseases and disorders described herein, by administering effective amounts of such compounds. Preferably, the compositions and methods provided herein inhibit PARP activity.

US Patent:

20090076122, Mar 19, 2009

Filed:

Dec 2, 2008

Appl. No.:

12/326798

Inventors:

Ernest KUN - Mill Valley CA, US
Jerome MENDELEYEV - San Francisco CA, US
Pal BAUER - Budapest, HU

Assignee:

BIPAR SCIENCES, INC. - Brisbane CA

International Classification:

A61K 31/404
A61K 31/352
A61P 35/00
A61P 25/00
A61P 3/00
A61P 37/00
A61P 29/00
A61P 31/12

US Classification:

514415, 514457

Abstract:

The invention relates to a method of modulating poly(ADP-ribose)polymerase-1 (PARP-1) activity in a mammal comprising administering to a mammal an effective amount of an organic aromatic compound having from 4 to about 35 carbon atoms, wherein said organic aromatic compound is capable of binding the arginine-34 moiety located in Zinc finger-1 of the PARP-1 enzyme and wherein said organic aromatic compound has electron donating capabilities such that it's π-electron system will interact with the positively charged (cationic) guanidinium moiety of the specific arginine-34 residue of the Zinc-1 finger of PARP-1 and does not contain benzamide or lactam substituents.In particular, substituted benzopyrones and substituted indoles and their pharmaceutical compositions containing such compounds that modulate the activity of PARP-1, are described. The invention is also directed to the composition of matter, kits and methods for their therapeutic and/or prophylactic use in treating diseases and disorders described herein, by administering effective amounts of such compounds. Preferably, the compositions and methods provided herein inhibit PARP activity.

US Patent:

20130331457, Dec 12, 2013

Filed:

Nov 29, 2012

Appl. No.:

13/689451

Inventors:

Jerome MENDELEYEV - San Francisco CA, US
Carol BASBAUM - San Francisco CA, US
Valeria S. OSSOVSKAYA - San Francisco CA, US

Assignee:

BIPAR SCIENCES, INC. - Bridgewater NJ

International Classification:

A61K 31/166
A61K 45/06

US Classification:

514619

Abstract:

Methods of treating bladder cancer are disclosed. The methods include administering to a patient a therapeutically effective amount of a 4-iodo-3-nitrobenzamide or a pharmaceutically acceptable salt thereof.

US Patent:

52625648, Nov 16, 1993

Filed:

Oct 30, 1992

Appl. No.:

7/969874

Inventors:

Ernest Kun - Mill Valley CA
Jerome Mendeleyev - San Francisco CA

Assignee:

Octamer, Inc. - Sausalito CA

International Classification:

C07C31131
A61K 31095

US Classification:

562430

Abstract:

The subject invention provides for novel anti-tumor and anti-retroviral compounds. More specifically, the invention relates to the sulfinic acid adducts of therapeutic C-nitroso compounds. The formation of the adducts increases the stability and more solubility of the C-nitroso compounds. These compounds include the L-cysteinesulfinic acid adducts of 6-nitroso-1,2-benzopyrone and 3-nitrosobenzamide. The invention also provides for compositions containing one or more of the compounds, and for methods of treating retroviral infections, cancer, infectious virus concentration with the subject compounds and compositions.

US Patent:

57835993, Jul 21, 1998

Filed:

Feb 27, 1996

Appl. No.:

8/607480

Inventors:

Ernest Kun - Mill Valley CA
Jerome Mendeleyev - San Francisco CA

International Classification:

A61K 3135

US Classification:

514457

Abstract:

Unsubstituted or substituted 5-iodo-6-amino-1,2-benzopyrones and their metabolites are potent, selective and non-toxic inhibitors and supressants of cancer growth and viral infections in a mammalian host. The compounds are particularly useful for treatment and supression of tumors and viruses associated with AIDS, herpetic episodes and cytomegaloviral infections. The methods of treatment of tumorigenic and viral diseases by 5-iodo-6-amino-1,2-benzopyrones and/or its metabolites are described.

US Patent:

54849519, Jan 16, 1996

Filed:

Oct 19, 1990

Appl. No.:

7/600593

Inventors:

Ernest Kun - Mill Valley CA
Jerome Mendeleyev - San Francisco CA

Assignee:

Octamer, Incorporated - Mill Valley CA

International Classification:

C07D31102

US Classification:

549285

Abstract:

Unsubstituted or substituted 5-iodo-6-amino-1,2-benopyrones and their metabolites are potent, selective and non-toxic inhibitors and suppressants of cancer growth and viral infections in a mammalian host. The compounds are particularly useful for treatment and suppression of tumors and viruses associated with AIDS, herpetic episodes and cytomegaloviral infections. The methods of treatment of tumorigenic and viral diseases by 5-iodo-6-amino-1,2-benzopyrones and/or its metabolites are described.