Jenchen Yang

US Patent:

20080139497, Jun 12, 2008

Filed:

Dec 8, 2006

Appl. No.:

11/636169

Inventors:

Jenchen Yang - Diamond Bar CA, US

International Classification:

A61K 31/7076
A61P 9/10

US Classification:

514 47

Abstract:

The invention is a method for controlled regional reperfusion using ATP-MgClafter percutaneous coronary revascularization for acute myocardial infarction, the method comprising the step of administering an effective amount of ATP-MgClto the step of administering an effective amount of ATP-MgClto the infarct-related vessel(s), such as at a dosage level of at least 0.03 mg/kg/min. The method also includes a method for controlled regional reperfusion using ATP-MgClafter percutaneous coronary revascularization for acute myocardial infarction, the method comprising the steps of (a) performing cardiac catheterization and coronary angiogram; (b) identifying the infarct-related vessel; (c) performing a left ventriculogram and calculating the left ventricular ejection fraction; and (d) performing a percutaneous coronary intervention; and after percutaneous revascularization of the infarct related vessel, infusing ATP-MgClintracoronary, preferably at a rate of at least 0.03 mg/kg/min through the balloon catheter.

US Patent:

20080085293, Apr 10, 2008

Filed:

Aug 22, 2006

Appl. No.:

11/507743

Inventors:

Jenchen Yang - Diamond Bar CA, US

International Classification:

A61F 2/02

US Classification:

424423

Abstract:

The present invention relates to a system and device for preventing stenosis and/or restenosis after an invasive procedure in a body vessel or cavity having an inner wall surface, the system comprising inserting a device coated with a growth arresting, lipid-derived, bioactive substance at a desired location along the inner wall surface of the body vessel or cavity. The present invention provides for the use of c-Jun aminoterminal kinase inhibitor (“JNK Inhibitor”) and certain analogs as restenosis inhibitors, incorporated into a stent.