Jay Marshall Edelberg

US Patent:

6650919, Nov 18, 2003

Filed:

May 3, 2001

Appl. No.:

09/848064

Inventors:

Jay M. Edelberg - New York NY
David J. Christini - Brooklyn NY

Assignee:

Cornell Research Foundation, Inc. - Ithaca NY

International Classification:

A61B 505

US Classification:

600345, 600300, 600365, 600373, 20440301, 435176

Abstract:

The present invention provides implantable physiological or pathophysiological biosensors. The subject biosensors comprise tissue or cells capable of carrying out a physiological or pathophysiological function, which can be used to monitor a chemical, physiological or pathophysiological variable associated with the physiological or pathophysiological function. In one embodiment, the tissue or cells are coupled via an electrical interface to an electronic measuring device or an electronic amplifying device. In another embodiment, the tissue or cells are coupled via an electrical interface to endogenous tissue or cells, including the blood. Preferably, the tissue or cells are excitable tissue or cells such as cardiac tissue or cells and neuronal tissue or cells. The subject biosensors may be placed, inserted or implanted in any animal including but not limited to a mouse, rat, rabbit, pig, cat, dog, cattle, horse, sheep or human. The present invention also provides various methods which employ a biosensor of the present invention.

US Patent:

6776987, Aug 17, 2004

Filed:

Jul 12, 2000

Appl. No.:

09/614326

Inventors:

Jay M. Edelberg - New York NY
Robert D. Rosenberg - Boston MA

Assignee:

Massachusetts Institute of Technology - Cambridge MA

International Classification:

A01N 6300

US Classification:

424 9321, 424 931, 424 932, 514 44

Abstract:

Molecularly-mediated and cellular-based -adrenergic receptor-dependent biological pacemakers are disclosed. Methods of using these compositions to improve cardiac chrontropic responsiveness by upregulating heart rate and altering cardiac rhythm are also disclosed.

US Patent:

7135171, Nov 14, 2006

Filed:

Feb 13, 2003

Appl. No.:

10/367639

Inventors:

Jay Edelberg - New York NY, US
Shahin Rafii - Great Neck NY, US
Mun Hong - New York NY, US
Robert P. Lanza - Clinton MA, US
Michael D. West - Southborough MA, US

Assignee:

Cornell Research Foundation, Inc. - Ithaca NY

International Classification:

A01N 63/00
A61K 48/00
A01N 43/04
C12P 21/06
C12N 5/00
C12N 16/63

US Classification:

424 931, 424 932, 424 9321, 424 937, 514 44, 435 691, 435325, 435455

Abstract:

The invention provides methods of treating and preventing loss of tissue vascularization that can occur, for example, upon aging.

US Patent:

7504379, Mar 17, 2009

Filed:

May 13, 2005

Appl. No.:

11/129076

Inventors:

Jay Edelberg - New York NY, US
Munira Xaymardan - Toronto, CA

Assignee:

Cornell Research Foundation, Inc. - Ithaca NY

International Classification:

A61K 38/18
A61K 38/19

US Classification:

514 12, 514 2

Abstract:

The invention provides compositions and methods for protecting vascular tissues from injury that occurs, for example, during occlusion of one or more arteries. In some embodiments, the injury is myocardial infarction. The compositions of the invention include combinations of platelet derived growth factor, vascular endothelial growth factor, and angiopoietin-2.

US Patent:

7514261, Apr 7, 2009

Filed:

Aug 8, 2002

Appl. No.:

10/215271

Inventors:

Jay M. Edelberg - New York NY, US
Shahin Rafii - Great Neck NY, US
Mun K. Hong - New York NY, US

Assignee:

Cornell Research Foundation, Inc. - Ithaca NY

International Classification:

C12N 5/00
C12N 5/08

US Classification:

435405, 435366, 435372, 435392

Abstract:

The invention provides methods of treating and preventing loss of tissue vascularization that can occur, for example, upon aging.

US Patent:

7910694, Mar 22, 2011

Filed:

Sep 18, 2003

Appl. No.:

10/527832

Inventors:

Jay M. Edelberg - New York NY, US
Dong Qing Cai - Guangzhou, CN
Barbara L. Hempstead - New York NY, US

Assignee:

Cornell Research Foundation, Inc. - Ithaca NY

International Classification:

A61K 38/04
A61K 38/00
A61K 51/00

US Classification:

530329, 530300, 530324, 514 11, 424 169

Abstract:

The present invention relates to peptides which selectively or preferentially home to areas of a heart. The invention further relates to conjugates of the homing peptides and uses thereof.

US Patent:

20020108131, Aug 8, 2002

Filed:

Sep 13, 2001

Appl. No.:

09/951936

Inventors:

Monty Krieger - Needham MA, US
Jay Edelberg - New York NY, US
Bernardo Trigatti - Hamilton, CA

International Classification:

A01K067/027
A61K049/00

US Classification:

800/003000, 800/014000, 800/018000, 800/009000, 424/009200

Abstract:

Transgenic animals that do not express functional SR-BI and ApoE develop severe atherosclerosis, by age four weeks in transgenic mice. Moreover, these animals exhibit progressive heart block by age four weeks, and die by age nine weeks. Pathology shows extensive fibrosis of the heart and occlusion of coronary arteries. The occlusion appears to be due to clotting, since fat deposition is in the walls. These animals are good models for the following diseases, and for screening of drugs useful in the treatment and/or prevention of these disorders: cardiac fibrosis, myocardial infarction, defects in electrical conductance, atherosclerosis, unstable plaque, and stroke. In contrast to other known models for atherosclerosis, these animals do not have to be fed extreme diets for long periods before developing atherosclerosis. No other known model for heart attacks and stroke is known.

US Patent:

20040137615, Jul 15, 2004

Filed:

Oct 21, 2003

Appl. No.:

10/690798

Inventors:

Jay Edelberg - New York NY, US
David Christini - Brooklyn NY, US

Assignee:

Cornell Research Foundation, Inc.

International Classification:

A61K048/00
C12N005/08

US Classification:

435/368000, 424/093210

Abstract:

The present invention provides implantable physiological or pathophysiological biosensors. The subject biosensors comprise tissue or cells capable of carrying out a physiological or pathophysiological function, which can be used to monitor a chemical, physiological or pathophysiological variable associated with the physiological or pathophysiological function. In one embodiment, the tissue or cells are coupled via an electrical interface to an electronic measuring device or an electronic amplifying device. In another embodiment, the tissue or cells are coupled via an electrical interface to endogenous tissue or cells, including the blood. Preferably, the tissue or cells are excitable tissue or cells such as cardiac tissue or cells and neuronal tissue or cells. The subject biosensors may be placed, inserted or implanted in any animal including but not limited to a mouse, rat, rabbit, pig, cat, dog, cattle, horse, sheep or human. The present invention also provides various methods which employ a biosensor of the present invention. Such methods include a method of monitoring physiological or pathophysiological function, a method of regulating output of a signal to a subject, and a method for controlling heart function.