Provided are methods increasing, or, alternatively, decreasing IL-6 and/or gp130-mediated signaling in mammalian subjects using p28. Methods of preventing and/or treating autoimmune disorders, cancer, transplant rejection, and other IL-6-associated diseases, as well as methods of enhancing an IL-6-mediated immune response, are also described.
Wsx-1/P28 As A Target For Anti-Inflammatory Responses
Compositions and methods relating to WSX-1 and p28 (IL-30) are provided. In particular, methods of treating inflammatory conditions in mammalian subjects using various WSX-1, p28, EBI3, and gp130 polypeptides and complexes or moieties that bind to or modulate activity of such complexes are described. Isolated or recombinant complexes including soluble WSX-1 or gp130 polypeptides, isolated or recombinant WSX-1 fusion proteins, and isolated or recombinant p28 fusion proteins are also described.
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Jason Stumhofer, Ph.D.
Assistant Professor, Department of Microbiology and Immunology Researc...
Jason Stumhofer 1995 graduate of Reading High School in Reading, PA is on Classmates.com. See pictures, plan your class reunion and get caught up with Jason and other high school ...