Jason R March

US Patent:

20080213812, Sep 4, 2008

Filed:

Jan 18, 2008

Appl. No.:

12/009623

Inventors:

William H. Andrews - Reno NV, US
Laura Briggs - Reno NV, US
Christopher Foster - Reno NV, US
Hamid Mohammadpour - Reno NV, US
Stephanie Fraser - Sparks NV, US
David Monda - Sparks NV, US
Lancer Brown - Sparks NV, US
Frederick M. Hahn - San Rafael CA, US
Ronald Pruzan - Palo Alto CA, US
David Schooley - Reno NV, US
Jason March - Reno NV, US

International Classification:

C12Q 1/48
C12N 5/06

US Classification:

435 15, 435375

Abstract:

Methods and compositions are provided for modulating, e.g., increasing or decreasing, the expression of telomerase reverse transcriptase (TERT). In the subject methods, the binding interaction of the TERT Site C repressor site with a Site C repressor protein complex made up of one or more proteins is modulated to achieve the desired change in TERT expression. A feature of the subject invention is that the target Site C repressor protein complex includes an LSF protein. The subject methods and compositions find use in a variety of different applications, including the immortalization of cells, the production of reagents for use in life science research, therapeutic applications; therapeutic agent screening applications; and the like.