Janet A Warrington

Author:

Janet Warrington

ISBN #:

0895940728

Author:

Janet Warrington

ISBN #:

0895940736

Author:

Janet Warrington

ISBN #:

0895945118

US Patent:

6806047, Oct 19, 2004

Filed:

Feb 6, 2001

Appl. No.:

09/776770

Inventors:

Martin J. Goldberg - Saratoga CA
Govinda Rao S. Yelagalawadi - San Jose CA
Eugene Yuji Tanimoto - Menlo Park CA
Huu Minh Tran - Milpitas CA
Helin Dong - Palo Alto CA
David Lockhart - Mountain View CA
Thomas B. Ryder - Los Gatos CA
Janet A. Warrington - Los Altos CA
Jody Beecher - San Jose CA

Assignee:

Affymetrix, Inc. - Santa Clara CA

International Classification:

C12Q 168

US Classification:

435 6, 4353201, 4352528, 435174, 435183, 382129, 382133, 382153, 382173, 382286, 382291, 702 19, 702 22, 935 10, 935 24, 935 72, 536 221

Abstract:

Methods and compounds are provided for detecting target molecules in a sample using specific binding assays. In particular, methods are provided for detecting a nucleic acid target in a sample. In one embodiment, the method comprises hybridizing a nucleic acid target, comprising a target nucleic acid sequence, to a nucleic acid probe, comprising a probe nucleic acid sequence, wherein the target comprises a binding ligand. The hydridized target is contacted with a receptor comprising multiple sites capable of binding the binding ligand to complex the receptor to the binding ligand, and the receptor is contacted with an amplification reagent, comprising a plurality of the binding ligands, to complex the amplification reagent to the receptor. The presence of the complexed amplification reagent then is detected, for example, by detecting the presence of a detectable label, such as a fluorescent label, for example, on the receptor or the amplification reagent. Optionally, the amplification reagent, comprising a plurality of the binding ligands, is contacted with labeled receptor molecules thereby to complex a plurality of labeled receptor molecules to the amplification reagent, and the labeled receptor molecules complexed to the amplification reagent are detected.

US Patent:

6841348, Jan 11, 2005

Filed:

Oct 19, 2000

Appl. No.:

09/693204

Inventors:

Janet A. Warrington - Los Altos CA, US
Mamatha Mahadevappa - Cupertino CA, US
Archana Nair - The Woodlands TX, US

Assignee:

Affymetrix, Inc. - Santa Clara CA

International Classification:

C12Q 168
C12P 1934
C07H 2104

US Classification:

435 6, 435 915, 435 9151, 536 231, 536 232, 536 235

Abstract:

This invention provides methods for discovering maintenance genes and for using maintenance genes. In one embodiment, the expression of at least three maintenance genes are measured and used as reference (or control) for comparing the expression of target genes in two or more biological samples.

US Patent:

6884578, Apr 26, 2005

Filed:

Dec 11, 2000

Appl. No.:

09/734752

Inventors:

Janet A. Warrington - Los Altos CA, US
Mamatha Mahadevappa - Cupertino CA, US

Assignee:

Affymetrix, Inc. - Santa Clara CA

International Classification:

C12Q001/68
C07H021/04

US Classification:

435 6, 536 231, 536 235

Abstract:

The present invention compares expression profiles from matched samples to identify differential gene expression. Samples are matched according to physiological, pharmacological and/or disease state. Comparison of matched samples eliminates gene expression differences that are the result of changes in variables that are not of interest. The gene expression differences that remain can be attributed with a high degree of confidence to the unmatched variation. The gene expression differences thus identified can be used for example to diagnose disease, identify physiological state, design drugs, and monitor therapies.

US Patent:

7108969, Sep 19, 2006

Filed:

Sep 10, 2001

Appl. No.:

09/950016

Inventors:

Janet A. Warrington - Los Altos CA, US
David T. W. Wong - Newton MA, US
Charles Randolph Todd - Boxford MA, US
Mamatha Mahadevappa - Cupertino CA, US

Assignee:

Affymetrix, Inc. - Santa Clara CA
President & Fellows of Harvard College - Cambridge MA

International Classification:

C12Q 1/68
C12P 19/34
C12M 1/34

US Classification:

435 6, 435 912, 4352872

Abstract:

Methods of monitoring the expression of genes in malignant oral cells is disclosed. Gene expression profiles are used to identify markers associated with malignant oral cells and to diagnose oral cancer.

US Patent:

8583380, Nov 12, 2013

Filed:

Sep 4, 2009

Appl. No.:

13/060425

Inventors:

Dietrich Stephan - San Francisco CA, US
Vern Norviel - San Jose CA, US
Janet Warrington - Los Altos CA, US
Doug Dolginow - Potomac MD, US

Assignee:

Aueon, Inc. - Menlo Park CA

International Classification:

G06F 19/10
G06F 19/18

US Classification:

702 20, 435 611

Abstract:

Personalized medicine involves the use of a patient's molecular markers to guide treatment regimens for the patient. The scientific literature provides multiple examples of correlations between drug treatment efficacy and the presence or absence of molecular markers in a patient sample. Methods are provided herein that permit efficient dissemination of scientific findings regarding treatment efficacy and molecular markers found in patient tumors to health care providers.

US Patent:

20030113762, Jun 19, 2003

Filed:

Aug 16, 2002

Appl. No.:

10/222206

Inventors:

Janet Warrington - Los Altos CA, US

International Classification:

C12Q001/68
G01N033/574
G06F019/00
G01N033/48
G01N033/50

US Classification:

435/006000, 435/007230, 702/019000, 702/020000

Abstract:

Sixty-four down regulated and 22 up regulated genes have been indentified in Gleason grade 4/5 cancer, using the gene profile from benign prostatic hyperplasia as control tissue. Hepsin appears to be the most promising of the up regulated genes. PSMA is also highly overexpressed at the transcript level in grade 4/5 cancer, re-emphasizing its potential importance as a target for chemotherapy. The regulated genes can be used diagnostically, prognostically, and therapeutically. They can be used to form prostate specific expression monitoring tools.

US Patent:

20030124539, Jul 3, 2003

Filed:

Dec 21, 2001

Appl. No.:

10/028482

Inventors:

Janet Warrington - Los Altos CA, US
Nila Shah - Cupertino CA, US

Assignee:

Affymetrix, Inc. A corporation organized under the laws of the State of Delaware

International Classification:

C12Q001/68
G06F019/00
G01N033/48
G01N033/50
C12M001/34

US Classification:

435/006000, 435/287200, 702/020000

Abstract:

In one embodiment of the invention, methods and systems are provided for high thoughput genotyping. The system includes an automated sample preparation system, a sample tracking system, automated array processing and system for data analysis.

US Patent:

20040029151, Feb 12, 2004

Filed:

Apr 9, 2003

Appl. No.:

10/411537

Inventors:

Mamatha Mahadevappa - Fremont CA, US
Zhaomei Zhang - Sunnyvale CA, US
Janet Warrington - Los Altos CA, US
John Palma - San Ramon CA, US
Mitchell Caldwell - Menlo Park CA, US
Zuxiong Chen - Sunnyvale CA, US
Zhenbin Fan - Mountain View CA, US
John McNeal - Oakland CA, US
Rosalie Nolley - Menlo Park CA, US
Thomas Stamey - Menlo Park CA, US

Assignee:

Affymetrix, INC. - Santa Clara CA

International Classification:

C12Q001/68

US Classification:

435/006000

Abstract:

Many genes are affected in prostate cancers which have not been previously identified. This includes genes that have been up-regulated or down-regulated. Monitoring the expression levels of these genes is useful to identify the existence of prostate cancer. Also, monitoring the expression levels of these genes is useful to predict the effectiveness of treatment, outcome, use of therapeutics, and screening drugs useful for the treatment of prostate cancer.