James L Sterling

US Patent:

7955841, Jun 7, 2011

Filed:

Sep 22, 2008

Appl. No.:

12/232669

Inventors:

Phil Belgrader - Severna Park MD, US
Christopher G. Cooney - Severn MD, US
Robert Doebler - Upland CA, US
Anna Hickerson - Altadena CA, US
Bruce Irvine - Glendora CA, US
Ali Nadim - San Marino CA, US
James Sterling - Upland CA, US
Reza Miraghaie - Culver City CA, US

Assignee:

Akonni Biosystems - Frederick MD

International Classification:

C12M 1/38

US Classification:

4353031, 435 912, 422138

Abstract:

A device for controlling temperature in a reaction chamber is disclosed. The device comprises: a bladder assembly comprising a housing dimensioned to hold a reaction chamber disposed within an interior volume of the housing; and a first temperature-control bladder disposed within the housing, the first temperature-control bladder is configured to receive a temperature-control fluid and comprises a flexible, heat conductive surface that comes in contact with at least a portion of an exterior surface of the reaction chamber after receiving the temperature-control fluid. Also disclosed are a bladder thermal cycler, a temperature-control bladder assembly and methods for producing a thermal cycle in a reaction chamber.

US Patent:

8153064, Apr 10, 2012

Filed:

Mar 21, 2008

Appl. No.:

12/052950

Inventors:

Christopher Cooney - Severn MD, US
Anna Hickerson - Altadena CA, US
James D. Sterling - Upland CA, US
Ali Nadim - San Marino CA, US

International Classification:

G01N 15/06
G01N 33/00
G01N 33/48
G01N 22/00
G01N 21/64
G01N 21/66
G01N 21/75
G01N 31/22
G01N 33/52
G01N 21/76
G01N 1/24
B01L 9/00

US Classification:

422 8208, 422 681, 422 8205, 422400, 422561, 436172, 7386311

Abstract:

An isothermal reaction and analysis system may include a receiver to receive sample holders, a thermal control subsystem to control a temperature of the receiver, an excitation subsystem, a detection subsystem and an analysis subsystem. Excitation sources and/or detectors are positioned to enhance data collection. Sample holders may include filters, selectively blocking and passing wavelengths or bands of electromagnetic radiation.

US Patent:

8334117, Dec 18, 2012

Filed:

Apr 29, 2011

Appl. No.:

13/098299

Inventors:

Phil Belgrader - Severna Park MD, US
Christopher G. Cooney - Severn MD, US
Robert Doebler - Upland CA, US
Anna Hickerson - Altadena CA, US
Bruce Irvine - Glendora CA, US
Ali Nadim - San Marino CA, US
James Sterling - Upland CA, US
Reza Miraghaie - Culver City CA, US

Assignee:

Akonni Biosystems, Inc. - Frederick MD

International Classification:

C12P 19/34

US Classification:

435 912, 422131, 422138

Abstract:

A device for controlling temperature in a reaction chamber is disclosed. The device comprises: a bladder assembly comprising a housing dimensioned to hold a reaction chamber disposed within an interior volume of the housing; and a first temperature-control bladder disposed within the housing, the first temperature-control bladder is configured to receive a temperature-control fluid and comprises a flexible, heat conductive surface that comes in contact with at least a portion of an exterior surface of the reaction chamber after receiving the temperature-control fluid. Also disclosed are a bladder thermal cycler, a temperature-control bladder assembly and methods for producing a thermal cycle in a reaction chamber.

US Patent:

8603783, Dec 10, 2013

Filed:

Aug 1, 2012

Appl. No.:

13/564523

Inventors:

Phillip Belgrader - Severna Park MD, US
Christopher G. Cooney - Severn MD, US
Robert Doebler - Upland CA, US
Anna Hickerson - Altadena CA, US
Bruce Irvine - Glendora CA, US
Ali Nadim - San Marino CA, US
James Sterling - Upland CA, US
Reza Miraghaie - Culver City CA, US

Assignee:

Akonni Biosystems, Inc. - Frederick MD

International Classification:

C12P 19/34

US Classification:

435 912, 422131, 422138

Abstract:

A device for controlling temperature in a reaction chamber is disclosed. The device comprises: a bladder assembly comprising a housing dimensioned to hold a reaction chamber disposed within an interior volume of the housing; and a first temperature-control bladder disposed within the housing, the first temperature-control bladder is configured to receive a temperature-control fluid and comprises a flexible, heat conductive surface that comes in contact with at least a portion of an exterior surface of the reaction chamber after receiving the temperature-control fluid. Also disclosed are a bladder thermal cycler, a temperature-control bladder assembly and methods for producing a thermal cycle in a reaction chamber.

US Patent:

20110207632, Aug 25, 2011

Filed:

Apr 29, 2011

Appl. No.:

13/098195

Inventors:

Phil Belgrader - Severna Park MD, US
Christopher G. Cooney - Severn MD, US
Robert Doebler - Upland CA, US
Anna Hickerson - Altadena CA, US
Bruce Irvine - Glendora CA, US
Ali Nadim - San Marino CA, US
James Sterling - Upland CA, US
Reza Miraghaie - Culver City CA, US

International Classification:

C40B 60/00
C12M 1/02

US Classification:

506 33, 4353031

Abstract:

A device for controlling temperature in a reaction chamber is disclosed. The device comprises: a bladder assembly comprising a housing dimensioned to hold a reaction chamber disposed within an interior volume of the housing; and a first temperature-control bladder disposed within the housing, the first temperature-control bladder is configured to receive a temperature-control fluid and comprises a flexible, heat conductive surface that comes in contact with at least a portion of an exterior surface of the reaction chamber after receiving the temperature-control fluid. Also disclosed are a bladder thermal cycler, a temperature-control bladder assembly and methods for producing a thermal cycle in a reaction chamber.

US Patent:

20120171756, Jul 5, 2012

Filed:

Mar 8, 2012

Appl. No.:

13/415709

Inventors:

Christopher Cooney - Severn MD, US
Anna Hickerson - Altadena CA, US
James D. Sterling - Upland CA, US
Ali Nadim - San Marino CA, US

International Classification:

C12M 1/38

US Classification:

4352861

Abstract:

An isothermal reaction and analysis system may include a receiver to receive sample holders, a thermal control subsystem to control a temperature of the receiver, an excitation subsystem, a detection subsystem and an analysis subsystem. Excitation sources and/or detectors are positioned to enhance data collection. Sample holders may include filters, selectively blocking and passing wavelengths or bands of electromagnetic radiation.

US Patent:

20160151785, Jun 2, 2016

Filed:

Jul 22, 2015

Appl. No.:

14/806438

Inventors:

- Claremont CA, US
Christopher Cooney - Severn MD, US
Anna Hickerson - Altadena CA, US
James D. Sterling - Upland CA, US
Ali Nadim - San Marino CA, US

International Classification:

B01L 7/00
G01N 21/64

Abstract:

An isothermal reaction and analysis system may include a receiver to receive sample holders, a thermal control subsystem to control a temperature of the receiver, an excitation subsystem, a detection subsystem and an analysis subsystem. Excitation sources and/or detectors are positioned to enhance data collection. Sample holders may include filters, selectively blocking and passing wavelengths or bands of electromagnetic radiation.

US Patent:

20140295534, Oct 2, 2014

Filed:

Jun 17, 2014

Appl. No.:

14/307253

Inventors:

- Claremont CA, US
Christopher Cooney - Severn MD, US
Anna Hickerson - Altadena CA, US
James D. Sterling - Upland CA, US
Ali Nadim - San Marino CA, US

International Classification:

C12Q 1/68

US Classification:

4352872

Abstract:

An isothermal reaction and analysis system may include a receiver to receive sample holders, a thermal control subsystem to control a temperature of the receiver, an excitation subsystem, a detection subsystem and an analysis subsystem. Excitation sources and/or detectors are positioned to enhance data collection. Sample holders may include filters, selectively blocking and passing wavelengths or bands of electromagnetic radiation.

Author:

James W. Sterling

ISBN #:

0882690000