James R Falsey

US Patent:

7148221, Dec 12, 2006

Filed:

Aug 1, 2005

Appl. No.:

11/195134

Inventors:

Elizabeth M. Doherty - Newbury Park CA, US
Jiawang Zhu - Simi Valley CA, US
Markian Stec - Fillmore CA, US
Mark H. Norman - Thousand Oaks CA, US
Hui-Ling Wang - Thousand Oaks CA, US
Christopher H. Fotsch - Thousand Oaks CA, US
Ning Chen - Thousand Oaks CA, US
Partha P. Chakrabarti - Simi Valley CA, US
Celia Dominguez - Thousand Oaks CA, US
James Richard Falsey - Westlake Village CA, US
Christopher Hulme - Simi Valley CA, US
Jodie Katon - Ventura CA, US
Thomas Nixey - Newbury Park CA, US
Vassil I. Ognyanov - Thousand Oaks CA, US
Liping H. Pettus - Thousand Oaks CA, US
Robert Michael Rzasa - Ventura CA, US

Assignee:

Amgen Inc. - Thousand Oaks CA

International Classification:

C07D 237/14
C07D 237/18
C07D 223/16
C07D 223/18
A61K 31/501
A61P 25/06

US Classification:

514247, 51425201, 514183, 51421703, 51422202, 5142268, 5142278, 5142288, 5142315, 514214, 514242, 514245, 544238, 544239, 544179, 544180, 540484, 540596

Abstract:

Compounds having the general structure.

US Patent:

7332511, Feb 19, 2008

Filed:

Aug 1, 2005

Appl. No.:

11/195159

Inventors:

Elizabeth M. Doherty - Newbury Park CA, US
Jiawang Zhu - Simi Valley CA, US
Markian Stec - Fillmore CA, US
Mark H. Norman - Thousand Oaks CA, US
Hui-Ling Wang - Thousand Oaks CA, US
Christopher H. Fotsch - Thousand Oaks CA, US
Ning Chen - Thousand Oaks CA, US
Partha P. Chakrabarti - Simi Valley CA, US
Celia Dominguez - Thousand Oaks CA, US
James Richard Falsey - Westlake Village CA, US
Christopher Hulme - Simi Valley CA, US
Jodie Katon - Ventura CA, US
Thomas Nixey - Newbury Park CA, US
Vassil I. Ognyanov - Thousand Oaks CA, US
Liping H. Pettus - Thousand Oaks CA, US
Robert Michael Rzasa - Ventura CA, US

Assignee:

Amgen Inc. - Thousand Oaks CA

International Classification:

C07D 213/30
C07D 213/32
C07D 401/12
C07D 401/14
C07D 403/12
C07D 403/14
A61K 31/4427
A61P 19/02
A61P 35/00

US Classification:

514345, 5462681, 544 8, 544 53, 544 56, 544 59, 544 63, 544 67, 544 88, 544106, 544238, 544242, 544338, 540450, 540484

Abstract:

Compounds having the general structure.

US Patent:

7511044, Mar 31, 2009

Filed:

Feb 11, 2005

Appl. No.:

11/056568

Inventors:

Hui-Ling Wang - Thousand Oaks CA, US
Chenera Balan - Thousand Oaks CA, US
Elizabeth M. Doherty - Newbury Park CA, US
James R. Falsey - Moorpark CA, US
Vijay Keshav Gore - Thousand Oaks CA, US
Jodie Katon - Ventura CA, US
Mark H. Norman - Thousand Oaks CA, US

Assignee:

Amgen Inc. - Thousand Oaks CA

International Classification:

C07D 403/04
A61K 31/496

US Classification:

51425214, 51425218, 51425219, 5142522, 544295

Abstract:

Pyrimidine ethers and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritus, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotising agents, hair growth, vasomotor or allergic rhinitis, bronchial disorders or bladder disorders.

US Patent:

7700593, Apr 20, 2010

Filed:

Oct 5, 2007

Appl. No.:

11/973076

Inventors:

Dawei Zhang - Thousand Oaks CA, US
Andrew Tasker - Simi Valley CA, US
Kelvin K. C. Sham - Thousand Oaks CA, US
Partha Pratim Chakrabarti - Nagpur, IN
James Richard Falsey - Moorpark CA, US
Bradley J. Herberich - Newbury Park CA, US
Liping H. Pettus - Thousand Oaks CA, US
Robert M. Rzasa - Ventura CA, US

Assignee:

Amgen Inc. - Thousand Oaks CA

International Classification:

A61K 31/5377
C07D 221/02
A61K 31/496
A61P 29/00
C07D 295/00
A61K 31/437

US Classification:

5142332, 514303, 514300, 51425304, 546119, 546121, 544127, 544362

Abstract:

The present invention comprises a new class of compounds useful for the prophylaxis and treatment of protein kinase mediated diseases, including inflammation and related conditions. The compounds have a general Formula I.

US Patent:

7745449, Jun 29, 2010

Filed:

Apr 23, 2007

Appl. No.:

11/789189

Inventors:

James R. Falsey - Moorpark CA, US
Robert M. Rzasa - Ventura CA, US
Seifu Tadesse - Simi Valley CA, US
Andrew Tasker - Simi Valley CA, US

Assignee:

Amgen Inc. - Thousand Oaks CA

International Classification:

C07D 495/04
C07D 413/12
A61K 31/519
A61K 31/5355
A61P 29/00
A61P 23/00
C07D 413/04
C07D 513/04
A61K 31/5025

US Classification:

5142601, 5142342, 514248, 544278, 544117, 5442342, 544235

Abstract:

The present invention comprises a new class of compounds useful for the prophylaxis and treatment of protein kinase mediated diseases, including inflammation and related conditions. The compounds have a general Formula I.

US Patent:

7759337, Jul 20, 2010

Filed:

Mar 2, 2006

Appl. No.:

11/367123

Inventors:

Andrew Tasker - Simi Valley CA, US
Dawei Zhang - Thousand Oaks CA, US
Guo-Qiang Cao - Thousand Oaks CA, US
Partha Pratim Chakrabarti - Newbury Park CA, US
James Richard Falsey - Moorpark CA, US
Bradley J. Herberich - Newbury Park CA, US
Randall W. Hungate - Camarillo CA, US
Liping H. Pettus - Thousand Oaks CA, US
Anthony Reed - Oxnard CA, US
Robert M. Rzasa - Ventura CA, US
Kelvin K. C. Sham - Thousand Oaks CA, US
Maya C. Thaman - Ventura CA, US
Shimin Xu - Santa Barbara CA, US

Assignee:

Amgen Inc. - Thousand Oaks CA

International Classification:

C07D 237/34
C07D 413/12
C07D 498/08
C07D 279/12
C07D 243/08
A61K 31/498
A61K 31/5355
A61K 31/537
A61K 31/541
A61K 31/551
A61P 29/00
A61P 23/00
C07D 487/04
A61K 31/4985

US Classification:

514218, 5142345, 5142305, 5142282, 514248, 540492, 544237, 544119, 544105, 544 582, 544236

Abstract:

The present invention comprises a new class of compounds useful for the prophylaxis and treatment of protein kinase mediated diseases, including inflammation and related conditions. The compounds have a general Formula I.

US Patent:

7897619, Mar 1, 2011

Filed:

Jul 16, 2008

Appl. No.:

12/218754

Inventors:

Qingping Zeng - Thousand Oaks CA, US
Dawei Zhang - Thousand Oaks CA, US
Guomin Yao - Newbury Park CA, US
George E. Wohlhieter - Lake Balboa CA, US
Xianghong Wang - Moorpark CA, US
James Rider - Woodland Hills CA, US
Andreas Reichelt - Moorpark CA, US
Holger Monenschein - Camarillo CA, US
James R. Falsey - Moorpark CA, US
Celia Dominguez - Los Angeles CA, US
Matthew P. Bourbeau - Woodland Hills CA, US
John G. Allen - Newbury Park CA, US

Assignee:

Amgen Inc. - Thousand Oaks CA

International Classification:

A61K 31/47
A61K 31/416
C07D 217/02
C07D 231/56

US Classification:

514311, 544224, 544235, 544242, 544253, 544283, 546112, 546139, 546152, 546157, 5483601, 5483611, 5483027, 5483064, 514248, 514299, 514387, 514403

Abstract:

The invention relates to heterocyclic compounds of Formula I and compositions thereof useful for treating diseases mediated by protein kinase B (PKB) where the variables have the definitions provided herein. The invention also relates to the therapeutic use of such compounds and compositions thereof in treating disease states associated with abnormal cell growth, cancer, inflammation, and metabolic disorders.

US Patent:

8247409, Aug 21, 2012

Filed:

Nov 11, 2009

Appl. No.:

12/616646

Inventors:

James R. Falsey - Moorpark CA, US
Seifu Tadesse - Simi Valley CA, US
Andrew Tasker - Simi Valley CA, US

Assignee:

Amgen Inc. - Thousand Oaks CA

International Classification:

A61K 31/5052
A61K 31/5377
C07D 413/14
C07D 487/04
A61P 17/00
A61P 19/00
A61P 25/00
A61P 31/12
A61P 11/00

US Classification:

5142342, 514248, 544235, 544117

Abstract:

The present invention comprises a new class of compounds useful for the prophylaxis and treatment of protein kinase mediated diseases, including inflammation and related conditions. The compounds have a general Formula I.