James J Crute

US Patent:

6348477, Feb 19, 2002

Filed:

Dec 8, 1999

Appl. No.:

09/456857

Inventors:

James J. Crute - Danbury CT
Anne-Marie Faucher - Oka, CA
Christine A. Grygon - New Milford CT
Karl D. Hargrave - Brookfield CT
Bruno Simoneau - Laval, CA
Bounkham Thavonekham - Longeuil, CA

Assignee:

Boehringer Ingelheim(Canada) Ltd. - Laval
Boehringer Ingelheim Pharmaceuticals, Inc. - Ridgefield CT

International Classification:

A61K 3144

US Classification:

514336, 514277, 514332, 514340, 546256, 5462681, 5462684, 5462697

Abstract:

This invention relates to methods for inhibiting herpes replication and for treating herpes infection in a mammal by inhibiting the herpes helicase-primase enzyme complex. This invention also relates to thiazolyphenyl derivatives that inhibit the herpes helicase-primase and to pharmaceutical compositions comprising the thiazolylphenyl derivatives, to methods of using and methods of producing the thiazolylphenyl derivatives.

US Patent:

6458959, Oct 1, 2002

Filed:

Oct 10, 2000

Appl. No.:

09/685686

Inventors:

James J. Crute - Danbury CT
Anne-Marie Faucher - Oka, CA
Christine A. Grygon - New Milford CT
Karl D. Hargrave - Brookfield CT
Bruno Simoneau - Laval, CA
Bounkham Thavonekham - Longeuil, CA

Assignee:

Boehringer Ingelheim Pharmaceuticals, Inc. - Ridgefield CT
Boehringer Ingelheim (Canada) Ltd. - Laval

International Classification:

C07D27700

US Classification:

548194, 548204, 514370

Abstract:

This invention relates to methods for inhibiting herpes replication and for treating herpes infection in a mammal by inhibiting the herpes helicase-primase enzyme complex. This invention also relates to thiazolyphenyl derivatives that inhibit the herpes helicase-primase and to pharmaceutical compositions comprising the thiazolylphenyl derivatives, to methods of using and methods of producing the thiazolylphenyl derivatives.

US Patent:

20030017503, Jan 23, 2003

Filed:

May 20, 2002

Appl. No.:

10/151133

Inventors:

Susan Goldrick - Danbury CT, US
Richard Nelson - Newtown CT, US
James Crute - San Diego CA, US
Ruby Wasti - Bethel CT, US
Gerald Nabozny - New Milford CT, US
John Proudfoot - Newtown CT, US
David Thomson - Ridgefield CT, US

Assignee:

Boehringer Ingelheim Pharmaceuticals, Inc. - Ridgefield CT

International Classification:

G01N033/53
C07J017/00

US Classification:

435/007100, 540/114000

Abstract:

The invention relates to fluorescence polarization (FP) methods for detecting and evaluating ligand binding to steroid receptors which are associated with heat shock proteins (hsps). The invention also relates to novel labeled molecules, in particular, fluorescence probes, which are useful in the methods of the invention.

US Patent:

61435074, Nov 7, 2000

Filed:

Oct 29, 1998

Appl. No.:

9/181958

Inventors:

Marilyn R. Kehry - Danbury CT
Steven S. Pullen - Danbury CT
James J. Crute - Danbury CT

Assignee:

Boehringer Ingelheim Pharmaceuticals, Inc. - Ridgefield CT

International Classification:

G01N 3353
G01N 33537
G01N 33534
C12Q 100
C07K 100

US Classification:

435 71

Abstract:

Disclosed is a high throughput compatible assay that is useful for the identification of specific antagonists of TRAF-receptor interactions. The modular flexibility of the assay makes it possible to introduce simple modifications in order to measure the interaction of any TNF receptor cytoplasmic domain (or TRAF-binding protein) with any of the six TRAF proteins, TRAF1, TRAF2, TRAF3, TRAF4, TRAF5 and TRAF6.

US Patent:

60574518, May 2, 2000

Filed:

Dec 4, 1996

Appl. No.:

8/759201

Inventors:

James J. Crute - Danbury CT
Anne-Marie Faucher - Oka, CA
Christine A. Grygon - New Milford CT
Karl D. Hargrave - Brookfield CT
Bruno Simoneau - Laval, CA
Bounkham Thavonekham - Longeuil, CA

Assignee:

Boehringer Ingelheim Pharmaceuticals, Inc. - Ridgefield CT

International Classification:

C07D27700
C07D27704
A61K 3138

US Classification:

548194

Abstract:

This invention relates to methods for inhibiting herpes replication and for treating herpes infection in a mammal by inhibiting the herpes helicase-primase enzyme complex. This invention also relates to thiazolyphenyl derivatives that inhibit the herpes helicase-primase and to pharmaceutical compositions comprising the thiazolylphenyl derivatives, to methods of using and methods of producing the thiazolylphenyl derivatives.

US Patent:

59586966, Sep 28, 1999

Filed:

May 22, 1998

Appl. No.:

9/083478

Inventors:

James J. Crute - Danbury CT

Assignee:

Boehringer Ingelheim Pharmaceuticals, Inc. - Ridgefield CT

International Classification:

C12Q 168
C12N 900
G01N 33566

US Classification:

435 6

Abstract:

This invention relates to a solid phase helicase assay for identifying helicase inhibitors. The assay having a model helicase substrate adsorbed on a solid support, the model helicase substrate being an immobilized extended single-stranded nucleic acid polymer hybridized to a labeled helicase reaction product. The presence of the labeled helicase reaction product is detectable in solution on helicase activity. Also described is a method for measuring the helicase inhibiting ability of test substances thus, making the assay useful for identifying pharmaceutically important helicase inhibitors.