Jacob M Hooker

US Patent:

20090317880, Dec 24, 2009

Filed:

Jun 22, 2009

Appl. No.:

12/488680

Inventors:

Jacob Matthew Hooker - Port Jefferson NY, US
Mathias Schonberger - Mains, DE
Hanno Schieferstein - Aabergen, DE
Joanna S. Fowler - Bellport NY, US

Assignee:

BROOKHAVEN SCIENCE ASSOCIATES, LLC - Upton NY

International Classification:

C07C 47/04
C07C 45/00
C12P 7/24

US Classification:

435147, 568490, 568448

Abstract:

Isotopically labeled formaldehyde (*CHO) is prepared from labeled methyl iodide (*CHI) by reaction with an oxygen nucleophile having a pendant leaving group. The mild and efficient reaction conditions result in good yields of *CHO with little or no *C isotopic dilution. The simple, efficient production of CHO is described. The use of the CHO for the formation of positron emission tomography tracer compounds is described. The reaction can be incorporated into automated equipment available to radiochemistry laboratories. The isotopically labeled formaldehyde can be used in a variety of reactions to provide radiotracer compounds for imaging studies as well as for scintillation counting and autoradiography.

US Patent:

20130045151, Feb 21, 2013

Filed:

Aug 13, 2012

Appl. No.:

13/584033

Inventors:

Dohyun Kim - Ridge NY, US
David Alexoff - Westhampton NY, US
Sung Won Kim - Port Jefferson NY, US
Jacob Hooker - Belmont MA, US
Richard A. Ferrieri - Patchogue NY, US

Assignee:

Brookhaven Science Associates, LLC - Upton NY

International Classification:

C01C 3/02
B01D 53/02
C07C 1/20
B01J 8/00

US Classification:

423249, 422649, 422187, 518715

Abstract:

A method for providing C-labeled cyanides from C labeled oxides in a target gas stream retrieved from an irradiated high pressure gaseous target containing O, wherein C labeled oxides are reduced with Hin the presence of a nickel catalyst under a pressure and a temperature sufficient to form a product stream comprising at least about 95% CH, the CHis then combined with an excess of NHin a carrier/reaction stream flowing at an accelerated velocity and the combined CH4 carrier/reaction stream is then contacted with a platinum (Pt) catalyst particulate supported on a substantially-chemically-nonreactive heat-stable support at a temperature of at least about 900 C., whereby a product stream comprising at least about 60% HCN is provided in less than 10 minutes from retrieval of the C labeled oxide.

US Patent:

20220348590, Nov 3, 2022

Filed:

Sep 10, 2020

Appl. No.:

17/642662

Inventors:

- Cambridge MA, US
- Boston MA, US
Antoine Bigot - Cambridge MA, US
Agathe Fayet - Cambridge MA, US
Besnik Bajrami - Cambridge MA, US
Jacob Hooker - Boston MA, US
Michael Placzek - Boston MA, US
Beth A. Stevens - Boston MA, US
Daniel Wilton - Boston MA, US
Steven McCarroll - Cambridge MA, US

Assignee:

The Board Institute, Inc. - Cambridge MA
The General Hospital Corporation - Boston MA
Children's Medical Center Corporation - Boston MA
President and Fellows of Harvard College - Cambridge MA

International Classification:

C07D 491/048
C07D 409/12
C07D 405/12
C07D 213/34
C07D 405/06
C07D 409/14
C07D 241/20
C07D 409/06
C07D 213/64
C07D 401/12
C07D 417/12
C07D 405/08
C07D 241/18
C07D 413/12
C07D 213/74
C07D 241/26
C07D 471/04
C07D 473/00
C07D 333/20
C07D 239/34
C07D 239/42
C07D 487/04
C07D 295/00

Abstract:

The present disclosure describes compounds of the formula: (I), (II), (III), (IV), (V). The compounds described herein may be cyclooxygenase (COX) (e.g., cyclooxygenase 2 (COX2)) inhibitors. The compounds may be radiolabeled. The compounds (e.g., radiolabeled compounds) may be useful (e.g., as positron emission tomography (PET) imaging agents) for diagnosing a disease. The compounds may also be useful for treating or preventing a disease. The present disclosure also describes pharmaceutical compositions and kits including the compounds; and methods of using the compounds.

US Patent:

20220281814, Sep 8, 2022

Filed:

Jul 30, 2020

Appl. No.:

17/631422

Inventors:

- Beverly MA, US
Jacob Matthew Hooker - Winchester MA, US
Stéphane Ouellet - Sudbury MA, US

Assignee:

Eikonizo Therapeutics, Inc. - Beverly MA

International Classification:

C07D 205/12
C07D 217/04
C07D 405/04
C07D 209/08
C07D 237/30
C07D 471/04
C07D 491/08
C07D 493/08
C07D 451/06
C07D 491/107
C07D 498/04
C07D 487/04

Abstract:

Provided herein are compounds that inhibit HDAC6, a protein whose activity is associated with a variety of diseases (e.g., cancer, neurological disorders). Also provided are pharmaceutical compositions and kits comprising the compounds, and methods of treating HDAC6-related diseases and disorders (e.g., Alzheimer's disease, cancer) with the compounds in a subject, by administering the compounds and/or compositions described herein.

US Patent:

20220267254, Aug 25, 2022

Filed:

Aug 5, 2021

Appl. No.:

17/395356

Inventors:

- Boston MA, US
Jacob Hooker - Charlestown MA, US

International Classification:

C07C 231/12
C07C 237/04

Abstract:

Provided herein are radiolabeled compounds useful for minimally invasive imaging techniques. An exemplary radiolabeled compound provided herein is useful as a radiotracer for position emission tomography imaging of voltage gated sodium channels. Methods for prepared unlabeled and labeled compounds, and diagnostic methods using the compounds are also provided.

US Patent:

20200031762, Jan 30, 2020

Filed:

Jan 11, 2018

Appl. No.:

16/477257

Inventors:

- Boston MA, US
Jacob Hooker - Charlestown MA, US

International Classification:

C07C 231/12
C07C 237/04

Abstract:

Provided herein are radiolabeled compounds useful for minimally invasive imaging techniques. An exemplary radiolabeled compound provided herein is useful as a radiotracer for position emission tomography imaging of voltage gated sodium channels. Methods for prepared unlabeled and labeled compounds, and diagnostic methods using the compounds are also provided.

US Patent:

20180258090, Sep 13, 2018

Filed:

Jul 17, 2015

Appl. No.:

15/326890

Inventors:

- Boston MA, US
Jacob M. Hooker - Belmont MA, US

International Classification:

C07D 473/40
C07B 59/00
A61K 51/04
C07D 473/16
C07D 487/04

Abstract:

Provided herein are radiolabeled compounds useful for non-invasive imaging techniques. An exemplary radiolabeled compound provided herein is useful as a radiotracer for positron emission tomography. The present application also provides unlabeled compounds useful in methods of treating diseases of the central nervous system or disease of the peripheral nervous system. Methods for preparing radiolabeled compounds, preparing unlabeled compounds, and diagnostic methods using labeled or unlabeled compounds are also provided.

US Patent:

20150217249, Aug 6, 2015

Filed:

Nov 24, 2014

Appl. No.:

14/551141

Inventors:

Dohyun Kim - Rocky Point NY, US
David Alexoff - Westhampton NY, US
Sung Won Kim - Port Jefferson NY, US
Jacob M. Hooker - Belmont MA, US
Richard A. Ferrieri - Patchogue NY, US

Assignee:

Brookhaven Science Associates, LLC - Upton NY

International Classification:

B01J 8/02
C01C 3/02

Abstract:

A method for providing C-labeled cyanides from C labeled oxides in a target gas stream retrieved from an irradiated high pressure gaseous target containing O, wherein C labeled oxides are reduced with Hin the presence of a nickel catalyst under a pressure and a temperature sufficient to form a product stream comprising at least about 95% 11, the CHis then combined with an excess of NHin a carrier/reaction stream flowing at an accelerated velocity and the combined CH4 carrier/reaction stream is then contacted with a platinum (Pt) catalyst particulate supported on a substantially-chemically-nonreactive heat-stable support at a temperature of at least about 900 C., whereby a product stream comprising at least about 60% H CN is provided in less than 10 minutes from retrieval of the C labeled oxide.