Hongbo C Liu

US Patent:

7238828, Jul 3, 2007

Filed:

Mar 24, 2005

Appl. No.:

11/088587

Inventors:

Hongbo Liu - Hillsborough NJ, US

Assignee:

Ethicon, Inc. - Somerville NJ

International Classification:

C07C 255/19
C08G 63/91
C08G 63/48
A61K 31/785

US Classification:

558442, 558441, 424 7827, 525 541

Abstract:

A monomer composition comprising at least one polymerizable alkyl ester α-cyanoacrylate monomer. Specifically, the α-cyanoacrylate monomer is an alkyl ester α-cyanoacrylate monomer of the general formula having a spacer R1:.

US Patent:

7534907, May 19, 2009

Filed:

May 30, 2007

Appl. No.:

11/755093

Inventors:

Hongbo Liu - Hillsborough NJ, US

Assignee:

Ethichon, Inc. - Somerville NJ

International Classification:

A61K 31/785
C07C 255/19
C08G 63/91
C08G 63/48

US Classification:

558442, 558441, 424 7827, 525 541

Abstract:

A monomer composition comprising at least one polymerizable alkyl ester α-cyanoacrylate monomer. Specifically, the α-cyanoacrylate monomer is an alkyl ester α-cyanoacrylate monomer of the general formula having a spacer R1:.

US Patent:

7713544, May 11, 2010

Filed:

Jul 30, 2001

Appl. No.:

10/343408

Inventors:

Elliot L. Chaikof - Atlanta GA, US
June Feng - Duluth GA, US
Janine M. Orban - Warsaw IN, US
Hongbo Liu - Hillsborough NJ, US
Xue Long Sun - Atlanta GA, US
Keith M. Faucher - Athens GA, US

Assignee:

Emory University - Atlanta GA

International Classification:

A61L 27/00
A61F 13/00
A61K 9/127

US Classification:

424450, 623 149, 623 242, 623 1111, 427 228, 427 23, 427 231, 424422, 424423

Abstract:

A biocompatible biological component is provided comprising a membrane-mimetic surface film covering a substrate. Suitable substrates include hydrated substrates, e. g. hydrogels which may contain drugs for delivery to a patient through the membrane-mimetic film, or may be made up of cells, such as islet cells, for transplantation. The surface may present exposed bioactive molecules or moieties for binding to target molecules in vivo, for modulating host response when implanted into a patient (e. g. the surface may be antithrombogenic or antiinflammatory) and the surface may have pores of selected sizes to facilitate transport of substances therethrough. An optional hydrophilic cushion or spacer between the substrate and the membrane-mimetic surface allows transmembrane proteins to extend from the surface through the hydrophilic cushion, mimicking the structure of naturally-occurring cells. An alkylated layer directly beneath the membrane-mimetic surface facilates bonding of the surface to the remainder of the biological component. Alkyl chains may extend entirely through the hydrophilic cushion when present.

US Patent:

7919480, Apr 5, 2011

Filed:

May 3, 2007

Appl. No.:

11/743815

Inventors:

Hongbo Liu - Hillsborough NJ, US
Xintian Ming - Bridgewater NJ, US

Assignee:

Ethicon, Inc. - Somerville NJ

International Classification:

A61K 31/717
C07H 15/20

US Classification:

514 54, 514 57, 536 136

Abstract:

An antimicrobial composition comprising: a complex of a polysaccharide covalently bonded with an antibiotic. A medical device having an antimicrobial composition comprising: a complex of an oxidized regenerated cellulose covalently bonded with gentamicin.

US Patent:

8475825, Jul 2, 2013

Filed:

May 25, 2010

Appl. No.:

12/786896

Inventors:

Hongbo Liu - Hillsborough NJ, US

Assignee:

Ethicon, Inc. - Somerville NJ

International Classification:

A61F 2/00

US Classification:

424423

Abstract:

The present invention is directed to curable compositions that comprise a non-porous substrate, one or more cyanoacrylate polymerization initiators and a prepolymer composition comprising at least one liquid cyanoacrylate monomer or mixture of such monomers (solid or liquid) and/or cyanoacrylate oligomers. The non-porous substrate is a collection of individual particulates that are not bound, bonded or fixed to one another. At least one initiator is deposited on the surface of the individual particulates to form a plurality of initiator carriers. The prepolymer composition receives the plurality of initiator carriers to begin a controlled and consistent polymerization or curing of the liquid cyanoacrylate monomer in order to produce a biocompatible adhesive composition for use on living tissue. The present invention also provides for methods of making and using and devices for such a curable compositions, particularly in treating living tissue by applying to living tissue a biocompatible adhesive composition.

US Patent:

20040073295, Apr 15, 2004

Filed:

Apr 15, 2003

Appl. No.:

10/257805

Inventors:

Elliot Chaikof - Atlanta GA, US
June Feng - Duluth GA, US
Janine Orban - Pittsburgh PA, US
Hongbo Liu - Willimantic CT, US

International Classification:

A61F002/06

US Classification:

623/001460

Abstract:

The present Specification describes materials and methods which provide for improved performance of medical prostheses, including vascular graft material, artificial heart valves, and other implanted materials. The materials comprising bound thrombomodulin or a functionally equivalent derivative protein, provide for fewer undesirable side effects including inflammation, thromboses and neointimal hyperplasia.

US Patent:

20070213553, Sep 13, 2007

Filed:

Mar 10, 2006

Appl. No.:

11/372959

Inventors:

Hongbo Liu - Hillsborough NJ, US
Sandra Gonzalez - Hillsborough NJ, US

International Classification:

C07C 253/30

US Classification:

558441000

Abstract:

A method for producing a cyanoacrylate monomer, comprising the steps of (a) reacting cyanoacetate and formaldehyde or paraformaldehyde in the presence of a base or amine base catalyst to form an α-cyanoacrylate prepolymer or oligomer mixture; (b) subjecting the α-cyanoacrylate prepolymer or oligomer mixture to a substrate having free acid, acid derivative, or free aldehyde or ketone groups to remove the catalyst and to obtain a purified α-cyanoacrylate prepolymer or oligomer; and (c) subjecting the purified α-cyanoacrylate prepolymer or oligomer to depolymerization to obtain an α-cyanoacrylate monomer.

US Patent:

20110230561, Sep 22, 2011

Filed:

Nov 17, 2009

Appl. No.:

13/130591

Inventors:

Hongbo Liu - Hillsborough NJ, US
Sandra Gonzalez - Bedminster NJ, US
Breda Mary Cullen - North Yorkshire, GB
Derek Walter Silcock - North Yorkshire, GB

International Classification:

A61K 47/16
A61K 31/192
A61K 31/16
C08F 120/44
A61P 29/00

US Classification:

514570, 514785, 514630, 526328

Abstract:

A medical adhesive composition comprising, based upon the total weight of the composition, from about 50 wt. % to about 99.9 wt. % of one or more α-cyanoacrylate monomers and from about 0.1 wt. % to about 5 wt. % of one or more non-steroidal anti-inflammatory drugs (NSAIDs). Suitable NSAIDs include ibuprofen and acetaminophen. The resulting compositions provide enhances fibroblast proliferation and reduced cytotoxicity compared to compositions that do not contain NSAID.