Guillaume X Durin

US Patent:

20120077283, Mar 29, 2012

Filed:

Sep 23, 2011

Appl. No.:

13/242665

Inventors:

Guillaume Durin - Boston MA, US

Assignee:

Covaris, Inc. - Woburn MA

International Classification:

G01N 1/28
B01L 3/00

US Classification:

436174, 422500

Abstract:

Systems and methods include processing devices used to fragment nucleic acids to average nucleic acid sizes ranging from between about 5 kbp and about 20 kbp. A processing device may include an inlet portion and a channel upstream from a shearing region arranged so that a relatively constant pressure is established and maintained (e.g., a pressure that changes by less than about 40%) at an entrance of the shearing region during a majority of sample flow through the shearing region. In some embodiments, after forcing the sample through the shearing region once, the processing device may be taken out of the centrifuge, inverted and placed back into the centrifuge so that the sample is forced through the shearing region again.

US Patent:

20140141413, May 22, 2014

Filed:

Nov 16, 2012

Appl. No.:

13/678755

Inventors:

- Woburn MA, US
Edwin Rudd - Salem NH, US
Guillaume Durin - Boston MA, US

Assignee:

Covaris, Inc. - Woburn MA

International Classification:

C12N 15/10

US Classification:

435 61, 422536

Abstract:

Method and apparatus for processing paraffin embedded samples, e.g., to disassociate paraffin from tissue components and/or other biomolecules from the paraffin. The sample may be exposed to focused acoustic energy while held in a vessel containing a non-solvent, aqueous solution. Disassociated paraffin may be emulsified into the liquid or otherwise separated from the sample.