Guangshan Shan Li

US Patent:

7141374, Nov 28, 2006

Filed:

Dec 5, 2003

Appl. No.:

10/729618

Inventors:

Yijia Bao - Painted Post NY, US
Guangshan Li - Corning NY, US
Nalini Raghavachari - Painted Post NY, US
Mingqian He - Painted Post NY, US
Xinying Xie - Painted Post NY, US
Yuming Xie - Painted Post NY, US

Assignee:

Corning Incorporated - Corning NY

International Classification:

C12Q 1/68
G01N 33/53

US Classification:

435 6, 435 71

Abstract:

A method of treating a substrate for immobilizing a biomolecule and substrates produced by the method are disclosed. The method includes contacting at least a portion of a substrate with a reducing agent such as a hydride. Treatment with an appropriate reducing agent substantially eliminates autofluorescence on substrates.

US Patent:

7364849, Apr 29, 2008

Filed:

Dec 5, 2003

Appl. No.:

10/729619

Inventors:

Yijia Bao - Painted Post NY, US
Guangshan Li - Corning NY, US
Nalini Raghavachari - Painted Post NY, US
Mingqian He - Painted Post NY, US
Xinying Xie - Painted Post NY, US
Yuming Xie - Painted Post NY, US

Assignee:

Corning Incorporated - Corning NY

International Classification:

C12Q 1/68
C07H 21/02
C07H 21/04

US Classification:

435 6, 536 231, 536 243

Abstract:

A method of treating a substrate for immobilizing a biomolecule and substrates produced by the method are disclosed. The method includes contacting at least a portion of a substrate with a reducing agent such as a hydride. Treatment with an appropriate reducing agent substantially eliminates autofluorescence on substrates.

US Patent:

8163561, Apr 24, 2012

Filed:

Nov 30, 2009

Appl. No.:

12/627463

Inventors:

Norman Henry Fontaine - Painted Post NY, US
Joydeep Lahiri - Painted Post NY, US
Guangshan Li - Painted Post NY, US
Anping Liu - Big Flats NY, US
Jinlin Peng - Painted Post NY, US

Assignee:

Corning Incorporated - Corning NY

International Classification:

G01N 21/00

US Classification:

436164, 356445

Abstract:

A surface plasmon resonance sensor system including a high refractive index prism, a sensor chip, a light source having multiple wavelengths over a broad range of wavelengths, optical lenses, a photodetector, a data acquisition unit, and as defined herein. The sensor chip can include, for example, a thin layer of silicon and gold on one face of a transparent substrate and the prism adjacent to the opposite face of the transparent substrate. Such an arrangement provides variable penetration depths up to about 1. 5 micrometers with a dynamic range for sensing index of refraction changes in a sample that are several times greater than that of a conventional SPR sensor. The disclosure provides methods for using the surface plasmon resonance sensor system for cell assay or chemical assay related applications.

US Patent:

20030036062, Feb 20, 2003

Filed:

Aug 9, 2001

Appl. No.:

09/925808

Inventors:

Yijia Bao - Painted Post NY, US
Guangshan Li - Corning NY, US
Nalini Raghavachari - Painted Post NY, US
Mingqian He - Painted Post NY, US
Xinying Xie - Painted Post NY, US
Yuming Xie - Painted Post NY, US

International Classification:

C12Q001/68
G01N033/53
G01N033/542
B05D003/00

US Classification:

435/006000, 435/007900, 427/002110

Abstract:

A method of treating a substrate for immobilizing a biomolecule and substrates produced by the method are disclosed. The method includes contacting at least a portion of a substrate with a reducing agent such as a hydride. Treatment with an appropriate reducing agent substantially eliminates autofluorescence on substrates.

US Patent:

20030082618, May 1, 2003

Filed:

Oct 15, 2002

Appl. No.:

10/271193

Inventors:

Guangshan Li - Corning NY, US
Uwe Muller - Waukegan IL, US
Yijia Bao - DesPlaines IL, US
Xinying Xie - Painted Post NY, US
Nalini Raghavachari - Painted Post NY, US

International Classification:

C12Q001/68
C12P019/34
B05D003/00

US Classification:

435/006000, 435/091200, 427/002110

Abstract:

Methods and DNA microarray devices for detecting or measuring genetic aberrations or changes in genomic DNA using comparative genomic hybridization (CGH) techniques and gene-expression assays are provided.

US Patent:

20070048747, Mar 1, 2007

Filed:

Sep 1, 2005

Appl. No.:

11/219049

Inventors:

Thomas Leslie - Horseheads NY, US
Guangshan Li - Corning NY, US
Jeffrey Lynn - Tioga PA, US
Jinlin Peng - Painted Post NY, US

International Classification:

C12Q 1/68
G01N 33/53
C12M 3/00
G01N 33/50

US Classification:

435006000, 435007100, 435287200, 977902000, 436086000

Abstract:

Described herein are methods for assaying analytes.

US Patent:

20090181409, Jul 16, 2009

Filed:

Jan 10, 2008

Appl. No.:

12/008309

Inventors:

Ye Fang - Painted Post NY, US
Guangshan Li - Corning NY, US

International Classification:

G01N 33/53

US Classification:

435 721, 435 72, 435 723

Abstract:

An apparatus and non-invasive method to measure cell-cell interactions, such as T-cell and stem cell interactions, under physiologically relevant conditions, and optionally measure the effects of stimuli on the cell-cell interactions, as defined herein.

US Patent:

20120133943, May 31, 2012

Filed:

Nov 29, 2010

Appl. No.:

12/955421

Inventors:

Norman Henry Fontaine - Painted Post NY, US
Guangshan Li - Painted Post NY, US
Anping Liu - Horseheads NY, US
Jinlin Peng - Painted Post NY, US

International Classification:

G01N 21/55

US Classification:

356445

Abstract:

Systems and methods for sensing a surface plasmon resonance (SPR) biosensor using two or more wavelengths and with reduced chromatic aberration are disclosed. The system includes a beam-forming optical system that has chromatic aberration at the two or more wavelengths. A light source system provides respectively light of the two or more wavelengths, with light of each wavelength provided from a different distance from the beam-forming optical system. The different distances are selected to reduce or eliminate adverse effects of chromatic aberration on the formation of a focus spot on the SPR biosensor chip. An illumination system for illuminating a SPR biosensor using different light having different wavelengths is also disclosed.