Gregory L Karrick

age ~64

from Portage, MI

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Process For The Preparation Of 1,5-Naphthyridine-3-Carboxyamides By Direct Ester Amidation
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US Patent:

20050038065, Feb 17, 2005
Filed:

May 28, 2004
Appl. No.:

10/856161
Inventors:

Gregory Karrick - Zeeland MI, US
David Ripin - Westbrook CT, US
Lulin Wei - Salem CT, US
International Classification:

C07D471/02
A61K031/4745
US Classification:

514300000, 546123000
Abstract:

A new route for the preparation of substituted 1,5-naphthyridine-3-carboxyamides, useful in the diagnosis and treatment of anxiety, Downs Syndrome, sleep, cognitive and seizure disorders, and overdose with benzodiazepine drugs and for enhancement of alertness, is provided. These compounds may be readily prepared by heating the corresponding 1,5-naphthyridine-3-carboxylic acid ester with a primary amine in a polar solvent such as dimethylformamide or dimethylsulfoxide.

Process For The Synthesis Of 3-Chloro-2,4,5-Trifluorobenzoic Acid
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US Patent:

48853860, Dec 5, 1989
Filed:

Oct 28, 1988
Appl. No.:

7/264296
Inventors:

James N. Wemple - Holland MI
Gregory L. Karrick - Holland MI
Floyd G. Spence - Holland MI
Assignee:

Warner-Lambert Company - Morris Plains NJ
International Classification:

C07C 51363
US Classification:

562493
Abstract:

An improved process for the preparation of 3-chloro-2,4,5-trifluorobenzoic acid is described which involves reaction of a diester of 3,4,5,6-tetrafluoro-1,2-benzenedicarboxylic acid with a substituted amine to afford 3-amino-2,4,5-trifluorobenzoic acid followed by subsequent conversion of the amio intermediate into 3-chloro-2,4,5-trifluorobenzoic acid.

Process For Preparing A Novel Phenicol Antibacterial Agent
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US Patent:

20210355086, Nov 18, 2021
Filed:

Sep 23, 2019
Appl. No.:

17/278385
Inventors:

- Parsippany NJ, US
Gregory Lee Karrick - Portage MI, US
Timothy Lee Stuk - Mattawan MI, US
International Classification:

C07D 213/71
B01J 31/04
B01J 31/24
Abstract:

The present invention provides a novel process for preparing a diastereomeric mixture of the phenicol of Formula (1), its use for the treatment of bacterial infections in animals, and veterinary compositions containing the Formula (1) compound, diastereomers thereof, and veterinary acceptable salts thereof.