Gregory M Jobin

US Patent:

44170637, Nov 22, 1983

Filed:

May 18, 1981

Appl. No.:

6/264482

Inventors:

Thomas B. K. Lee - Whitehouse Station NJ
George E. Lee - Somerville NJ
Gregory M. Jobin - Bridgewater NJ

Assignee:

Hoechst-Roussel Pharmaceuticals Inc. - Somerville NJ

International Classification:

C07D31312

US Classification:

549354

Abstract:

A method for the preparation of 6,11-dihydro-11-oxodibenz[b,e]oxepin-acetic acids having pharmaceutical activity is disclosed. Compounds represented by the formula: ##STR1## wherein R is OH or Cl are provided as intermediates. An aldehyde of the formula: ##STR2## wherein R. sub. 1 is a lower alkyl, e. g. , 1 to 4 carbon atoms, is reacted with chloroform and aqueous base to form an. alpha. -hydroxy dicarboxylic acid. Alternatively, the aldehyde can be converted to the corresponding cyanohydrin, which is then converted to the corresponding. alpha. -hydroxy dicarboxylic acid. The. alpha. -hydroxy dicarboxylic acid can also be prepared from reaction of a halogenated toluate of the formula: ##STR3## wherein X is Cl or Br with mandelic acid or a derivative thereof of the formula: ##STR4## wherein R. sub. 3 and R. sub. 4 are independently selected from hydrogen and alkyl of 1 to 4 carbon atoms. The. alpha. -hydroxy dicarboxylic acid is cyclized and then converted to the oxepin acetic acid by reduction.

US Patent:

45799814, Apr 1, 1986

Filed:

Aug 13, 1984

Appl. No.:

6/640264

Inventors:

Gregory M. Shutske - Nauheim, DE
Thomas B. K. Lee - Whitehouse Station NJ
Gregory M. Jobin - Bridgewater NJ

Assignee:

Hoechst-Roussel Pharmaceuticals Inc. - Somerville NJ

International Classification:

C07C 4122

US Classification:

568649

Abstract:

An improved process for the preparation of 2-chloro-1,3-dimethoxybenzene involving the reaction of [2,6-dimethoxyphenyl]lithium with chlorinating agents is disclosed. 2-Chloro-1,3-dimethoxybenzene is useful as a starting material for the synthesis of pharmacologically valuable 1,2-benzisoxazoloxyacetic acids.

US Patent:

43049419, Dec 8, 1981

Filed:

Aug 1, 1980

Appl. No.:

6/174399

Inventors:

Thomas B. K. Lee - White House Station NJ
Gregory M. Jobin - Bridgewater NJ

Assignee:

Hoechst Roussel Pharmaceuticals, Inc. - Somerville NJ

International Classification:

C07C 4546

US Classification:

568322

Abstract:

A method of preparing substituted acylbenzenes is disclosed. The method comprises reacting selected acylhalides or equivalents with a selected poly-substituted benzene in the presence of an acylating catalyst comprising a clay.

Address:

201 N Brg St, Somerville, NJ 08876

Phone:

9082180105

VIN:

1GCCS139X98116893

Make:

CHEVROLET

Model:

COLORADO

Year:

2009