Golfo Skokotas from 663 Aronimink Pl, Oakview, PA 19026, age 59, Phone: 6102842182

Golfomycin Derivatives: Fused Ring Cyclodecadiyne Derivatives Having Dna-Cleaving Properties And Antitumor Activity
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US Patent:

51360993, Aug 4, 1992
Filed:

Aug 1, 1990
Appl. No.:

7/561964
Inventors:

Golfo Skokotas - San Diego CA
Kyriacos C. Nicolaou - La Jolla CA
Assignee:

Scripps Clinic and Research Foundation - La Jolla CA
International Classification:

C07C 49223
US Classification:

568327
Abstract:

5-Hydroxy-benzo-(1',2')-cyclodeca-2,7-diyne-1-one and derivatives thereof and related fused ring diyneone macrocyclic compounds are disclosed. The compounds possess DNA-cleaving, antibiotic and tumor growth-inhibiting properties. Methods of making and using the same are also disclosed.

Propargylic And Allenic Sulfones
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US Patent:

52371018, Aug 17, 1993
Filed:

Jan 26, 1990
Appl. No.:

7/470814
Inventors:

K. C. Nicolaou - La Jolla CA
Guido Zaccarello - Philadelphia PA
Golfo Skokotas - San Diego CA
Peter Maligres - San Diego CA
Assignee:

The Trustees of the Univ. of Penna. - Philadelphia PA
International Classification:

C07C31500
US Classification:

568 28
Abstract:

Propargylic and allenic sulfones are disclosed having the ability to selectively cleave nucleic acids, especially deoxyribonucleic acid. Such compositions are capable of being synthetically modified to effect cleavage at selected, sequenced sites on nucleic acids.

Golfo Skokotas