Gene R Gould

US Patent:

7352459, Apr 1, 2008

Filed:

Dec 31, 2001

Appl. No.:

10/039769

Inventors:

Gene Gould - Cardiff CA, US
Michael J. Conrad - Escondido CA, US

Assignee:

Chromagen, Inc. - Escondido CA

International Classification:

G01J 3/18
G01N 21/64

US Classification:

356318, 356333, 2504581

Abstract:

A fluorescence spectrophotometer system may be implemented in scanning fluorescence polarization detection applications. A wavelength and area scanning fluorescence spectrophotometer system may include a light source, an excitation double monochromator, an excitation/emission light transfer module, an emission double monochromator, a high speed timer-counter circuit board, a precision positioning apparatus for positioning a sample relative to the focal plane of the excitation light, and polarizing filters at the excitation side and the emission side. The system may be operative to analyze more than one fluorescent compound in the sample; additionally or alternatively, the system enables analysis of samples from selected ones of a plurality of samples.

US Patent:

7411673, Aug 12, 2008

Filed:

Sep 8, 2003

Appl. No.:

10/658363

Inventors:

Gene Gould - Cardiff CA, US
Michael J. Conrad - Escondido CA, US

Assignee:

Chromagen, Inc. - San Diego CA

International Classification:

G01N 21/64

US Classification:

356317, 2504581, 356318

Abstract:

A fluorescence spectrophotometer having an excitation double monochromator, a coaxial excitation/emission light transfer module, and an emission double monochromator. Each monochromator includes a pair of holographic concave gratings mounted to precisely select a desired band of wavelengths from incoming broadband light without using other optical elements, such as mirrors. Selected excitation light is directed into a sample well by a light transfer module that includes a coaxial excitation mirror positioned to direct excitation light directly to the bottom of a well of a multi-well plate. Fluorescence emission light that exits the well opening is collected by a relatively large coaxial emission mirror. The collected emission light is wavelength selected by the emission double monochromator. Selected emission light is detected by a photodetector module.

US Patent:

20080225289, Sep 18, 2008

Filed:

Mar 31, 2008

Appl. No.:

12/060170

Inventors:

Gene Gould - Cardiff CA, US
Michael J. Conrad - Escondido CA, US

Assignee:

CHROMAGEN, INC. - San Diego CA

International Classification:

G01J 3/40

US Classification:

356303

Abstract:

A fluorescence spectrophotometer system may be implemented in scanning fluorescence polarization detection applications. A wavelength and area scanning fluorescence spectrophotometer system may include a light source, an excitation double monochromator, an excitation/emission light transfer module, an emission double monochromator, a high speed timer-counter circuit board, a precision positioning apparatus for positioning a sample relative to the focal plane of the excitation light, and polarizing filters at the excitation side and the emission side. The system may be operative to analyze more than one fluorescent compound in the sample; additionally or alternatively, the system enables analysis of samples from selected ones of a plurality of samples.

US Patent:

20080309933, Dec 18, 2008

Filed:

Aug 5, 2008

Appl. No.:

12/186509

Inventors:

GENE GOULD - Cardiff CA, US
Michael J. Conrad - Escondido CA, US

Assignee:

ARIES ASSOCIATES, INC. - San Diego CA

International Classification:

G01N 21/64
G01J 1/58

US Classification:

356317, 2504581

Abstract:

A fluorescence spectrophotometer having an excitation double monochromator, a coaxial excitation/emission light transfer module, and an emission double monochromator. Each monochromator includes a pair of holographic concave gratings mounted to precisely select a desired band of wavelengths from incoming broadband light without using other optical elements, such as mirrors. Selected excitation light is directed into a sample well by a light transfer module that includes a coaxial excitation mirror positioned to direct excitation light directly to the bottom of a well of a multi-well plate. Fluorescence emission light that exits the well opening is collected by a relatively large coaxial emission mirror. The collected emission light is wavelength selected by the emission double monochromator. Selected emission light is detected by a photodetector module.

US Patent:

20080309934, Dec 18, 2008

Filed:

Aug 6, 2008

Appl. No.:

12/186514

Inventors:

GENE GOULD - Cardiff CA, US
Michael J. Conrad - Escondido CA, US

Assignee:

ARIES ASSOCIATES, INC. - San Diego CA

International Classification:

G01J 3/30

US Classification:

356318

Abstract:

A fluorescence spectrophotometer having an excitation double monochromator, a coaxial excitation/emission light transfer module, and an emission double monochromator. Each monochromator includes a pair of holographic concave gratings mounted to precisely select a desired band of wavelengths from incoming broadband light without using other optical elements, such as mirrors. Selected excitation light is directed into a sample well by a light transfer module that includes a coaxial excitation mirror positioned to direct excitation light directly to the bottom of a well of a multi-well plate. Fluorescence emission light that exits the well opening is collected by a relatively large coaxial emission mirror. The collected emission light is wavelength selected by the emission double monochromator. Selected emission light is detected by a photodetector module.

US Patent:

6654119, Nov 25, 2003

Filed:

Apr 20, 2000

Appl. No.:

09/552803

Inventors:

Gene Gould - Cardiff CA
Michael J. Conrad - Escondido CA

Assignee:

Chromagen, Inc. - San Diego CA

International Classification:

G01N 2164

US Classification:

356318, 356333, 2504581

Abstract:

A fluorescence spectrophotometer having an excitation double monochromator, a coaxial excitation/emission light transfer module, and an emission double monochromator. Each monochromator includes a pair of holographic concave gratings mounted to precisely select a desired band of wavelengths from incoming broadband light without using other optical elements, such as mirrors. Selected excitation light is directed into a sample well by a light transfer module that includes a coaxial excitation mirror positioned to direct excitation light directly to the bottom of a well of a multi-well plate. Fluorescence emission light that exits the well opening is collected by a relatively large coaxial emission mirror. The collected emission light is wavelength selected by the emission double monochromator. Selected emission light is detected by a photodetector module.