Raymond J. A. Budde - Bellaire TX Jonathan A. Ellman - Oakland CA Victor A. Levin - Houston TX Gary E. Gallick - Kingwood TX Robert A. Newman - Sugar Land TX
Assignee:
Board of Regents, The University of Texas System - Austin TX The Regents of the University of California - Oakland CA
International Classification:
A61K 315513 A61P 2500 C07D24316
US Classification:
514221
Abstract:
Disclosed herein are small molecule, non-peptidyl inhibitors of protein tyrosine kinases, and methods for their use. The instant inhibitors are based on a 1,4-benzodiazepin-2-one nucleus. Methods are provided for inhibition of specific protein tyrosine kinases, for example pp60. sup. c-src. Methods are further provided for the use of these inhibitors in situations where the inhibition of a protein tyrosine kinase is indicated, for example, in the treatment of certain diseases in mammals, including humans.