Ganapati R Mauze

US Patent:

6375627, Apr 23, 2002

Filed:

Mar 2, 2000

Appl. No.:

09/517711

Inventors:

Ganapati R. Mauze - Sunnyvale CA
Paul Lum - Los Altos CA
Dominique Freeman - La Honda CA

Assignee:

Agilent Technologies, Inc. - Palo Alto CA

International Classification:

A61B 500

US Classification:

600584, 600309

Abstract:

A device for sampling and analyzing a physiological fluid from the skin of a patient by puncture. The device includes a body and sensors. The body has a needle with a point for puncturing a physiological tissue and a channel in the body for conducting the physiological fluid away from the point. The sensors are located in the body and are accessible to the physiological fluid conducting along the channel for physiological fluid analysis. The device can be used to lance the skin and obtain a representative sample of the physiological fluid, with relatively simple procedures and quick analysis to minimize the exposure of the physiological fluid sample to air.

US Patent:

6379969, Apr 30, 2002

Filed:

Mar 2, 2000

Appl. No.:

09/517259

Inventors:

Ganapati R. Mauze - Sunnyvale CA
Bo Curry - Redwood City CA

Assignee:

Agilent Technologies, Inc. - Palo Alto CA

International Classification:

G01N 2164

US Classification:

436 68, 436 74, 436 79, 436 95, 436 98, 436163, 436172, 422 8205, 422 8207, 422 8208

Abstract:

A device for analyzing simultaneously multiple analytes in a fluid of unknown composition. The device includes a plurality of sensors, a light source for providing light to shine on the sensors, light detectors, and a processor. The sensors are exposed to a sample of the fluid of unknown composition. The plurality of sensors includes groups of sensors, each group targeting a specific analyte and including one or more sensors that contain an analyte-specific chemical that interacts more specifically with one analyte than with some other analytes to be analyzed. Each sensor in each group has a different chemical interacting with the analyte to target it. The light source shines light on the sensors of the plurality of sensors to cause light interaction with the sensors. The differences in the sensors lead to differences in the light interaction. The light detectors detects the light interaction by the sensors.

US Patent:

6933026, Aug 23, 2005

Filed:

Feb 6, 2003

Appl. No.:

10/360568

Inventors:

Ganapati Mauze - Sunnyvale CA, US
Nikhil Trilokekar - Fremont CA, US

Assignee:

Aradgim Corporation - Hayward CA

International Classification:

B32B001/02

US Classification:

428 357, 428345, 428421

Abstract:

A method for producing a polymeric film resistant to degradation during sterilization such as gamma irradiation is presented. The method includes the steps of minimizing the number of free radicals formed during sterilization through use of an inert gas and a reactant scavenger within a sterilization pouch, which reactant scavenger may be acid adsorbents which scavenge the acid by-products formed during irradiation. The films retain physical and mechanical properties with long-term storage. The films are particularly amenable for use as packaging laminates in pharmaceutical, food, semiconductor and medical device industries.

US Patent:

6939721, Sep 6, 2005

Filed:

Dec 18, 2000

Appl. No.:

09/740660

Inventors:

Ganapati R. Mauze - Sunnyvale CA, US
Dan-Hui Yang - Sunnyvale CA, US

Assignee:

Agilent Technologies, Inc. - Palo Alto CA

International Classification:

G01N033/545
G01N033/552
G01N033/533

US Classification:

436531, 436527, 436546, 436800, 436805, 436829

Abstract:

The invention includes a composition of matter and method that utilizes energy transfer between one or more donor and acceptor molecules. The composition of matter includes an encapsulation vesicle having a matrix, a surface coating of an organo-metallic complex and a transparent protection layer. The transparent protection layer is capable of modification by addition of biomolecules to the surface in order to bind other molecules. The proximity of the bound biomolecules to the protective layer allows for energy transfer from a donor molecule internal to the protection layer to an acceptor molecule outside the protection layer. The protection layer acts to diminish the effects of collisional quenching on the donor molecules caused by ubiquitous small molecules such as molecular oxygen. The application also teaches a method of making and applying the complexes to immunoassays.

US Patent:

6974703, Dec 13, 2005

Filed:

Mar 11, 2004

Appl. No.:

10/798982

Inventors:

Ganapati R. Mauze - Sunnyvale CA, US
Dan-Hui Yang - Sunnyvale CA, US

Assignee:

Agilent Technologies, Inc. - Palo Alto CA

International Classification:

G01N033/00
C12Q001/68
C12M001/34
C07H021/04

US Classification:

436 94, 435 6, 4352872, 536 231, 536 243

Abstract:

The invention provides an apparatus and method for detection of a target molecule. The apparatus includes a probe labeled with a transition metal-ligand complex that hybridizes with the target to form an initial complex, a metal ion for doping the initial complex and forming a final complex, and a potential means for providing a potential to the final complex to produce a detectable signal indicating the presence of the target after redox reaction. The method of the invention teaches the steps of hybridizing a probe with an attached label to the target to produce an initial complex, adding a metal ion to the initial complex to form a final complex and applying a potential to the final complex to produce a measurable signal.

US Patent:

7029919, Apr 18, 2006

Filed:

May 4, 2001

Appl. No.:

09/848869

Inventors:

Ganapati R. Mauze - Sunnyvale CA, US
Dan-Hui Yang - Sunnyvale CA, US

Assignee:

Agilent Technologies, Inc. - Palo Alto CA

International Classification:

G01N 33/00
C12Q 1/68
C07H 21/04

US Classification:

436 94, 436800, 436805, 435 6, 536 231, 536 243

Abstract:

The invention provides an apparatus and method for detection of a target molecule. The apparatus includes a probe labeled with a transition metal-ligand complex that hybridizes with the target to form an initial complex, a metal ion for doping the initial complex and forming a final complex, and a potential means for providing a potential to the final complex to produce a detectable signal indicating the presence of the target after redox reaction. The method of the invention teaches the steps of hybridizing a probe with an attached label to the target to produce an initial complex, adding a metal ion to the initial complex to form a final complex and applying a potential to the final complex to produce a measurable signal.

US Patent:

7049129, May 23, 2006

Filed:

Apr 15, 2003

Appl. No.:

10/414719

Inventors:

Ganapati R. Mauze - Sunnyvale CA, US
Dan-Hui Yang - Sunnyvale CA, US

Assignee:

Agilent Technologies, Inc. - Palo Alto CA

International Classification:

C12M 1/34
C12Q 1/68
G01N 33/20
G01N 33/00

US Classification:

4352872, 435 6, 435810, 436 73, 436 94, 436182, 536 231, 536 243, 536 2532

Abstract:

The invention provides an apparatus and method for detection of a target molecule. The apparatus includes a probe labeled with a transition metal-ligand complex that hybridizes with the target to form an initial complex, a metal ion for doping the initial complex and forming a final complex, and a potential means for providing a potential to the final complex to produce a detectable signal indicating the presence of the target after redox reaction. The method of the invention teaches the steps of hybridizing a probe with an attached label to the target to produce an initial complex, adding a metal ion to the initial complex to form a final complex and applying a potential to the final complex to produce a measurable signal.

US Patent:

7056475, Jun 6, 2006

Filed:

Jan 30, 2002

Appl. No.:

10/058797

Inventors:

Paul Lum - Los Altos CA, US
Ganapati R. Mauze - Sunnyvale CA, US
Catherine K. Templin - Portola Valley CA, US

Assignee:

Agilent Technologies, Inc. - Palo Alto CA

International Classification:

G01N 33/00

US Classification:

422100, 422 99, 422101, 422103, 422 58, 422 681, 422 81, 436180

Abstract:

An apparatus and method for pumping and optionally mixing of small quantities of biological fluid wherein the pumping mechanism is segregated from the biological fluid being pumped. The micro-pump pushes the biological fluid by compressing a cartridge housing the blood and reagents with collapsible walls with a roller or ball bearing, synchronized perpendicular plungers, or an acutely-angled member to push the biological fluid by collapsing the walls of the cartridge in the direction of flow.