Fredric D Gordon

US Patent:

20140004503, Jan 2, 2014

Filed:

Dec 30, 2011

Appl. No.:

13/977108

Inventors:

Michael J. Cima - Winchester MA, US
Gregory J. Ekchian - Belmont MA, US
Christophoros C. Vassiliou - Cambridge MA, US
Vincent H. Liu - Cambridge MA, US
Christoph Wald - Nahant MA, US
Sebastian Flacke - Nahant MA, US
Fredric D. Gordon - Newton MA, US

Assignee:

LAHEY CLINIC FOUNDATION, INC. - Burlington MA
MASSACHUSETTS INSTITUTE OF TECHNOLOGY - Cambridge MA

International Classification:

G01N 1/34

US Classification:

435 5, 435 612, 435 792, 4352831, 435 71

Abstract:

Trapping devices and methods are provided for capturing a medical analyte, in blood or another biological fluid. The device may include a structural substrate and a binding agent, such as an antibody, affixed to the structural substrate, wherein the binding agent is capable of binding or attaching with a medical analyte, such as a viral particle, and the device is configured for placement in a biological cavity or vessel (containing a biological fluid) in a patient. The trapping device, which may be in a twisted coil shape, is configured to trap at least some of the medical analyte, such a viral particle, present in the biological fluid. The method may include deploying a trapping device into the patient's blood vessel; after a period following the deployment, removing the trapping device from the biological cavity or blood vessel; and then analyzing the trapping device for the presence of the medical analyte.

US Patent:

20160341639, Nov 24, 2016

Filed:

Jun 23, 2016

Appl. No.:

15/190634

Inventors:

- Cambridge MA, US
- Burlington MA, US
Christophoros C. Vassiliou - Cambridge MA, US
Vincent H. Liu - Cambridge MA, US
Christoph Wald - Nahant MA, US
Sebastian Flacke - Nahant MA, US
Fredric D. Gordon - Newton MA, US

International Classification:

G01N 1/34
G01N 33/53
A61F 2/01
G01N 33/569

Abstract:

Trapping devices and methods are provided for capturing a medical analyte, in blood or another biological fluid. The device may include a structural substrate and a binding agent, such as an antibody, affixed to the structural substrate, wherein the binding agent is capable of binding or attaching with a medical analyte, such as a viral particle, and the device is configured for placement in a biological cavity or vessel (containing a biological fluid) in a patient. The trapping device, which may be in a twisted coil shape, is configured to trap at least some of the medical analyte, such a viral particle, present in the biological fluid. The method may include deploying a trapping device into the patient's blood vessel; after a period following the deployment, removing the trapping device from the biological cavity or blood vessel; and then analyzing the trapping device for the presence of the medical analyte.