Frank Gu - Cambridge MA, US Benjamin Teply - Omaha NE, US Robert Langer - Newton MA, US Omid Farokhzad - Chestnut Hill MA, US
Assignee:
Massachusetts Institute of Technology - Cambridge MA The Brigham & Women's Hospital, Inc. - Boston MA
International Classification:
A61K 9/14 A61K 38/43 C40B 50/00 A61K 47/32
US Classification:
424489000, 424094100, 506023000, 514772400
Abstract:
The present invention generally relates to polymers and macromolecules, in particular, to block polymers useful in particles such as nanoparticles. One aspect of the invention is directed to a method of developing nanoparticles with desired properties. In one set of embodiments, the method includes producing libraries of nanoparticles having highly controlled properties, which can be formed by mixing together two or more macromolecules in different ratios. One or more of the macromolecules may be a polymeric conjugate of a moiety to a biocompatible polymer. In some cases, the nanoparticle may contain a drug. The moiety, in some embodiments, may have a molecular weight greater than about 1000 Da; for example, the moiety may include a polypeptide or a polynucleotide, such as an aptamer. The moiety may also be a targeting moiety, an imaging moiety, a chelating moiety, a charged moiety, or a therapeutic moiety. Another aspect of the invention is directed to systems and methods of producing such polymeric conjugates. In some embodiments, a solution containing a polymer is contacted with a liquid, such as an immiscible liquid, to form nanoparticles containing the polymeric conjugate. Other aspects of the invention are directed to methods using such libraries, methods of using or administering such polymeric conjugates, methods of promoting the use of such polymeric conjugates, kits involving such polymeric conjugates, or the like.
Methods And Compositions For Altering Biological Surfaces
Jeffrey M. Karp - BROOKLINE MA, US Alireza Khademhosseini - Cambridge MA, US David A. Berry - Brookline MA, US Robert S. Langer - Newton MA, US Frank X. Gu - Cambridge MA, US
Assignee:
Massachusetts Institute of Technology - Cambridge MA
Compositions, methods and kits are provided for altering the properties of a biological surface using particles such as, for instance, calcium based particles in combination with an agent that binds to the biological surface. Properties such as color, sheen, texture, strength, and odor of biological surfaces such as teeth and bone are alterable.
Rohit Karnik - Cambridge MA, US Frank X. Gu - Cambridge MA, US Pamela Basto - Somerville MA, US Chris Cannizzaro - Cambridge MA, US Alireza Khademhosseini - Cambridge MA, US Robert S. Langer - Newton MA, US Omid C. Farokhzad - Chestnut Hill MA, US
International Classification:
C08J 3/14 B01J 2/00
US Classification:
523105, 4222451
Abstract:
The present invention provides microfluidic systems and methods for the production of particles (e.g., nanoparticles) for drug delivery. The present invention provides microfluidic devices useful for production of particles by nanoprecipitation. The present invention provides highly homogenous compositions of particles produced by inventive microfluidic devices.