Farukh A Durrani

US Patent:

7534818, May 19, 2009

Filed:

Sep 15, 2003

Appl. No.:

10/663109

Inventors:

Youcef M. Rustum - Amherst NY, US
Shousong Cao - East Amherst NY, US
Farukh Durrani - Snyder NY, US
Karoly Toth - North Amherst NY, US
Peter Kanter - East Aurora NY, US
Harry Slocum - Kenmore NY, US

Assignee:

Health Research, Inc. - Buffalo NY

International Classification:

A01N 59/02

US Classification:

514561, 514706

Abstract:

The present invention discloses a method for reducing alopecia and bladder toxicity associated with the anti-cancer agent cyclophosphamide. The method comprises administering to an individual, in need of such a treatment, cyclophosphamide and a selenium compound. The selenium compounds may be administered before, during or after administration of the anti-cancer agent.

US Patent:

20040110838, Jun 10, 2004

Filed:

Dec 10, 2002

Appl. No.:

10/315721

Inventors:

Youcef Rustum - Amherst NY, US
Shousong Cao - East Amherst NY, US
Farukh Durrani - Snyder NY, US

International Classification:

A61K031/198
A61K031/7072
A61K031/4745

US Classification:

514/561000, 514/050000, 424/649000, 514/449000, 514/283000

Abstract:

The present invention discloses a method for enhancing the efficacy of anti-cancer agents. The method comprises administering to an individual, in need of such a treatment, an anti-cancer agent and a selenium compound. The selenium compounds may be administered before, during or after administration of the anti-cancer agent.

US Patent:

20040180099, Sep 16, 2004

Filed:

Dec 12, 2003

Appl. No.:

10/734570

Inventors:

Youcef Rustum - Amherst NY, US
Shousong Cao - East Amherst NY, US
Farukh Durrani - Snyder NY, US

International Classification:

A61K033/04
A61K031/704
A61K031/198
A61K031/28

US Classification:

424/702000, 514/034000, 514/561000, 514/492000

Abstract:

The present invention discloses a method for reducing the toxicity of anti-cancer agents oxaliplatin and doxorubicin. The method comprises administering to an individual, in need of such a treatment, the anti-cancer agent and a selenium compound. The selenium compounds may be administered before, during or after administration of the anti-cancer agent.

US Patent:

20050026852, Feb 3, 2005

Filed:

May 13, 2004

Appl. No.:

10/844800

Inventors:

Youcef Rustum - Amherst NY, US
Shousong Cao - East Amherst NY, US
Farukh Durrani - Snyder NY, US

International Classification:

A61K031/704
A61K031/513
A61K031/198
A61K031/337

US Classification:

514034000, 514449000, 514109000, 514561000, 514492000, 514049000, 514269000

Abstract:

A method for augmenting the antitumor activity of anti-cancer agents is provided. The method comprises administering to an individual an anti-cancer agent and a selenium compound. The selenium compounds may be administered before, during or after administration of the anti-cancer agent.

US Patent:

20060258697, Nov 16, 2006

Filed:

Apr 17, 2006

Appl. No.:

11/405377

Inventors:

Youcef Rustum - Amherst NY, US
Shousong Cao - East Amherst NY, US
Farukh Durrani - Getzville NY, US
Marwan Fakih - Williamsville NY, US

International Classification:

A61K 31/198
A61K 31/4745
A61K 31/337

US Classification:

514283000, 514449000, 514561000

Abstract:

A method for augmenting the antitumor activity of anti-cancer agents is provided. The method comprises administering to an individual an anti-cancer and a selenium compound. A method is also provided for inhibiting the growth of a tumor which-has proven to be refractory to anticancer agents. The methods comprises administration of selenium compound followed by administration of the anticancer agent.

US Patent:

20210236840, Aug 5, 2021

Filed:

Jan 30, 2020

Appl. No.:

16/777765

Inventors:

- East Amherst NY, US
- Buffalo NY, US
Joseph Cacaccio - Buffalo NY, US
Farukh Durrani - Buffalo NY, US
Adam Sumlin - Getzville NY, US
Eric Kauffman - Buffalo NY, US

International Classification:

A61N 5/06
A61N 7/00
A61K 41/00

Abstract:

New advantageous compositions and methods for treatment of malignancies such as basel cell carcinoma and other skin cancers, brain tumors, head and neck cancer, kidney cancer, prostate cancer and other cancer types. The new compositions and methods may also be used for treatment of non-cancer problems such as dermatological diseases, sexual diseases, anti-fungal and antibacterial and wound healing. A new photodynamic therapy/sonodynamic therapy (PDT/SDT) combination approach using near infrared (NIR) tetrapyrrolic photosensitizers (PSs) with long wavelength absorption, in the range of 750-800 nm, that provides deeper tissue penetration. Such combinations may be postloaded onto PAA nanoparticles (NPs) for better delivery to a tumor site. A preferred sonodynamic compound is fullerene 60 but other sonodynamic compounds may be employed. The unique NP formulations of the invention can contain chemotherapeutic agents releasable by ultrasound in cancer or other hyperproliferative tissue. NP formulations may also contain tumor targeting moieties.

US Patent:

20200308184, Oct 1, 2020

Filed:

Sep 21, 2018

Appl. No.:

16/649582

Inventors:

- Buffalo NY, US
Zachary GROSSMAN - Buffalo NY, US
Ravindra CHERUKU - Buffalo NY, US
Joseph MISSERT - Buffalo NY, US
Joseph SPERNYAK - West Seneca NY, US
Craig M. HENDLER - Buffalo NY, US
Ronald A. ALBERICO - Buffalo NY, US
Sandra SEXTON - Buffalo NY, US
Farukh DURRANI - East Amherst NY, US

International Classification:

C07D 487/22
A61K 41/00
A61K 49/00
A61K 49/08

Abstract:

The present disclosure provides compounds comprising a tetrapyrrole (e.g., a tetrapyrrole group) linked via a linker to one or more ligands and uses of the compounds. The compounds may be used as imaging agents (e.g., MRI contrast agents) or as both imaging and therapeutic agents. The compounds may be used to treat individuals in need of treatment for a hyperproliferative disorder, such as, for example, malignancy. The present disclosure also provides kits comprising pharmaceutical preparations containing any one or any combination of the compounds described herein.

US Patent:

20200078459, Mar 12, 2020

Filed:

Dec 13, 2017

Appl. No.:

16/469581

Inventors:

- Buffalo NY, US
Farukh DURRANI - East Amherst NY, US
Khurshid GURU - East Amherst NY, US

International Classification:

A61K 41/00
A61N 5/06
A61K 49/00

Abstract:

Methods for treatment of cancer are provided. The methods are based on the use of both NIR photosensitizer(s) and chemotherapy agent(s). The NIR photosensitizers have a tetrapyrrolic core or reduced tetrapyrrolic core. Also provided are pharmaceutical compositions comprising NIR photosensitizer(s) and chemotherapy agent(s). Also provided are kits comprising NIR photosensitizer(s) and chemotherapy agent(s) and instructions for their use.