- Lexington MA, US Fabio Felix - Lexington MA, US Bhavin Shah - Lexington MA, US Matthew Bernasconi - Lexington MA, US Said Rizk - Lexington MA, US David P. Martin - Lexington MA, US Simon F. Williams - Lexington MA, US
Resorbable multifilament yarns and monofilament fibers including poly-4-hydroxybutyrate and copolymers thereof with high tenacity or high tensile strength have been developed. The yarns and fibers are produced by cold drawing the multifilament yarns and monofilament fibers before hot drawing the yarns and fibers under tension at temperatures above the melt temperature of the polymer or copolymer. These yarns and fibers have prolonged strength retention in vivo making them suitable for soft tissue repairs where high strength and strength retention is required. The multifilament yarns have tenacities higher than 8.1 grams per denier, and in vivo, retain at least 65% of their initial strength at 2 weeks. The monofilament fibers retain at least 50% of their initial strength at 4 weeks in vivo. The monofilament fibers have tensile strengths higher than 500 MPa. These yarns and fibers may be used to make various medical devices for various applications.
- Lexington MA, US Fabio Felix - Foxborough MA, US Said Rizk - Windham NH, US David P. Martin - Arlington MA, US Simon F. Williams - Cambridge MA, US
International Classification:
A61F 2/18 A61F 2/00 A61L 27/54 A61L 27/58
Abstract:
Implants with fillable reservoirs have been developed that are suitable for rhinoplasty, breast reconstruction, ear reconstruction, and replacement, reconstruction or repair of other soft tissues. The implants can be filled with graft material prior to implantation. The implants are preferably made from resorbable polymers, can be tailored to provide different geometries, mechanical properties and resorption rates in order to provide more consistent surgical outcomes. The implants preferably have an interconnected network of unit cells with microporous outer layers and optionally some or all of the unit cells having at least one macropore in their outer layers. The implants can be loaded by injection with microfat, collagen, DCF, cells, bioactive agents, and other augmentation materials, prior to implantation.
- Lexington MA, US Emily Stires - Cambridge MA, US Rebecca Holmes - North Reading MA, US Said Rizk - Windham NH, US Arikha Moses - New York NY, US Fabio Felix - Foxborough MA, US Bruce Van Natta - Westfield IN, US Antonio Fosco - North Reading MA, US David P. Martin - Arlington MA, US Simon F. Williams - Cambridge MA, US
Absorbable implants for breast surgery that conform to the breast parenchyma and surrounding chest wall have been developed. These implants support newly lifted breast parenchyma, and/or a breast implant. The implants have mechanical properties sufficient to support a reconstructed breast, and allow the in-growth of tissue into the implant as it degrades. The implants have a strength retention profile allowing the support of the breast to be transitioned from the implant to regenerated host tissue, without significant loss of support. Three-dimensional implants for use in minimally invasive mastopexy/breast reconstruction procedures are also described, that confer shape to a patient's breast. These implants are self-reinforced, can be temporarily deformed, implanted in a suitably dissected tissue plane, and resume their preformed three-dimensional shape. The implants are preferably made from poly-4-hydroxybutyrate (P4HB) and copolymers thereof. The implants have suture pullout strengths that can resist the mechanical loads exerted on the reconstructed breast.
Methods Of Orienting Multifilament Yarn And Monofilaments Of Poly-4-Hydroxybutyrate And Copolymers Thereof
- Lexington MA, US Fabio Felix - Foxborough MA, US Bhavin Shah - Lowell MA, US Matthew Bernasconi - Norwood MA, US Said Rizk - Windham NH, US David P. Martin - Arlington MA, US Simon F. Williams - Cambridge MA, US
Resorbable multifilament yarns and monofilament fibers including poly-4-hydroxybutyrate and copolymers thereof with high tenacity or high tensile strength have been developed. The yarns and fibers are produced by cold drawing the multifilament yarns and monofilament fibers before hot drawing the yarns and fibers under tension at temperatures above the melt temperature of the polymer or copolymer. These yarns and fibers have prolonged strength retention in vivo making them suitable for soft tissue repairs where high strength and strength retention is required. The multifilament yarns have tenacities higher than 8.1 grams per denier, and in vivo, retain at least 65% of their initial strength at 2 weeks. The monofilament fibers retain at least 50% of their initial strength at 4 weeks in vivo. The monofilament fibers have tensile strengths higher than 500 MPa. These yarns and fibers may be used to make various medical devices for various applications.
- Lexington MA, US Emily Stires - Cambridge MA, US Rebecca Holmes - North Reading MA, US Said Rizk - Windham NH, US Arikha Moses - New York NY, US Fabio Felix - Foxborough MA, US Bruce Van Natta - Westfield IN, US
International Classification:
A61F 2/12 A61F 2/00
Abstract:
Absorbable implants for breast surgery that conform to the breast parenchyma and surrounding chest wall have been developed. These implants support newly lifted breast parenchyma, and/or a breast implant. The implants have mechanical properties sufficient to support a reconstructed breast, and allow the in-growth of tissue into the implant as it degrades. The implants have a strength retention profile allowing the support of the breast to be transitioned from the implant to regenerated host tissue, without significant loss of support. Three-dimensional implants for use in minimally invasive mastopexy/breast reconstruction procedures are also described, that confer shape to a patient's breast. These implants are self-reinforced, can be temporarily deformed, implanted in a suitably dissected tissue plane, and resume their preformed three-dimensional shape. The implants are preferably made from poly-4-hydroxybutyrate (P4HB) and copolymers thereof. The implants have suture pullout strengths that can resist the mechanical loads exerted on the reconstructed breast.
Methods Of Orienting Multifilament Yarn And Monofilaments Of Poly-4-Hydroxybutyrate And Copolymers Thereof
- Lexington MA, US Fabio Felix - Foxborough MA, US Bhavin Shah - Lowell MA, US Matthew Bernasconi - Norwood MA, US Said Rizk - Windham NH, US David P. Martin - Arlington MA, US Simon F. Williams - Sherborn MA, US
Resorbable multifilament yarns and monofilament fibers including poly-4-hydroxybutyrate and copolymers thereof with high tenacity or high tensile strength have been developed. The yarns and fibers are produced by cold drawing the multifilament yarns and monofilament fibers before hot drawing the yarns and fibers under tension at temperatures above the melt temperature of the polymer or copolymer. These yarns and fibers have prolonged strength retention in vivo making them suitable for soft tissue repairs where high strength and strength retention is required. The multifilament yarns have tenacities higher than 8.1 grams per denier, and in vivo, retain at least 65% of their initial strength at 2 weeks. The monofilament fibers retain at least 50% of their initial strength at 4 weeks in vivo. The monofilament fibers have tensile strengths higher than 500 MPa. These yarns and fibers may be used to make various medical devices for various applications.
Methods Of Orienting Multifilament Yarn And Monofilaments Of Poly-4-Hydroxybutyrate And Copolymers Thereof
- Lexington MA, US Fabio Felix - Foxborough MA, US Bhavin Shah - Lowell MA, US Matthew Bernasconi - Norwood MA, US Said Rizk - Windham NH, US David P. Martin - Arlington MA, US Simon F. Williams - Sherborn MA, US
Resorbable multifilament yarns and monofilament fibers including poly-4-hydroxybutyrate and copolymers thereof with high tenacity or high tensile strength have been developed. The yarns and fibers are produced by cold drawing the multifilament yarns and monofilament fibers before hot drawing the yarns and fibers under tension at temperatures above the melt temperature of the polymer or copolymer. These yarns and fibers have prolonged strength retention in vivo making them suitable for soft tissue repairs where high strength and strength retention is required. The multifilament yarns have tenacities higher than 8.1 grams per denier, and in vivo, retain at least 65% of their initial strength at 2 weeks. The monofilament fibers retain at least 50% of their initial strength at 4 weeks in vivo. The monofilament fibers have tensile strengths higher than 500 MPa. These yarns and fibers may be used to make various medical devices for various applications.
- Lexington MA, US Emily Stires - Boston MA, US Rebecca Marciante - North Reading MA, US Said Rizk - Windham NH, US Arika Moses - New York NY, US Fabio Felix - Foxborough MA, US Bruce Van Natta - Westfield IN, US
Absorbable implants for breast surgery that conform to the breast parenchyma and surrounding chest wall have been developed. These implants support newly lifted breast parenchyma, and/or a breast implant. The implants have mechanical properties sufficient to support a reconstructed breast, and allow the in-growth of tissue into the implant as it degrades. The implants have a strength retention profile allowing the support of the breast to be transitioned from the implant to regenerated host tissue, without significant loss of support. Three-dimensional implants for use in minimally invasive mastopexy/breast reconstruction procedures are also described, that confer shape to a patient's breast. These implants are self-reinforced, can be temporarily deformed, implanted in a suitably dissected tissue plane, and resume their preformed three-dimensional shape. The implants are preferably made from poly-4-hydroxybutyrate (P4HB) and copolymers thereof. The implants have suture pullout strengths that can resist the mechanical loads exerted on the reconstructed breast.
Tepha, Inc. Jan 2015 - Jul 2017
Staff Engineer
Tepha, Inc. Jan 2015 - Jul 2017
Manager of Manufacturing
Tepha, Inc. Jan 2012 - Jan 2014
Senior Development Engineer
Tepha, Inc. Jan 2010 - Jan 2012
R and D Engineer
Tepha, Inc. Feb 2007 - Jan 2010
Manufacturing Engineer
Education:
Virginia Tech 2006 - 2006
Northeastern University 1995 - 2001
Bachelors, Bachelor of Science, Mechanical Engineering
Northeastern University 1990 - 1994
Bachelors, Bachelor of Science
Skills:
Design of Experiments Medical Devices Manufacturing Product Design Plastics Polymers Materials R&D Minitab Quality System Product Development Injection Molding Solidworks Lean Manufacturing Six Sigma Process Improvement