Fabio G Felix

US Patent:

20200240044, Jul 30, 2020

Filed:

Mar 9, 2020

Appl. No.:

16/813430

Inventors:

- Lexington MA, US
Fabio Felix - Lexington MA, US
Bhavin Shah - Lexington MA, US
Matthew Bernasconi - Lexington MA, US
Said Rizk - Lexington MA, US
David P. Martin - Lexington MA, US
Simon F. Williams - Lexington MA, US

International Classification:

D01F 6/62
A61L 17/10
A61L 31/14
D01D 5/08
B29C 55/00
A61L 31/06
D02G 3/04
D01F 8/14
B29K 73/00
B29K 673/00
B29L 31/00

Abstract:

Resorbable multifilament yarns and monofilament fibers including poly-4-hydroxybutyrate and copolymers thereof with high tenacity or high tensile strength have been developed. The yarns and fibers are produced by cold drawing the multifilament yarns and monofilament fibers before hot drawing the yarns and fibers under tension at temperatures above the melt temperature of the polymer or copolymer. These yarns and fibers have prolonged strength retention in vivo making them suitable for soft tissue repairs where high strength and strength retention is required. The multifilament yarns have tenacities higher than 8.1 grams per denier, and in vivo, retain at least 65% of their initial strength at 2 weeks. The monofilament fibers retain at least 50% of their initial strength at 4 weeks in vivo. The monofilament fibers have tensile strengths higher than 500 MPa. These yarns and fibers may be used to make various medical devices for various applications.

US Patent:

20190151081, May 23, 2019

Filed:

Nov 19, 2018

Appl. No.:

16/195144

Inventors:

- Lexington MA, US
Fabio Felix - Foxborough MA, US
Said Rizk - Windham NH, US
David P. Martin - Arlington MA, US
Simon F. Williams - Cambridge MA, US

International Classification:

A61F 2/18
A61F 2/00
A61L 27/54
A61L 27/58

Abstract:

Implants with fillable reservoirs have been developed that are suitable for rhinoplasty, breast reconstruction, ear reconstruction, and replacement, reconstruction or repair of other soft tissues. The implants can be filled with graft material prior to implantation. The implants are preferably made from resorbable polymers, can be tailored to provide different geometries, mechanical properties and resorption rates in order to provide more consistent surgical outcomes. The implants preferably have an interconnected network of unit cells with microporous outer layers and optionally some or all of the unit cells having at least one macropore in their outer layers. The implants can be loaded by injection with microfat, collagen, DCF, cells, bioactive agents, and other augmentation materials, prior to implantation.

US Patent:

20190125519, May 2, 2019

Filed:

Aug 23, 2018

Appl. No.:

16/110933

Inventors:

- Lexington MA, US
Emily Stires - Cambridge MA, US
Rebecca Holmes - North Reading MA, US
Said Rizk - Windham NH, US
Arikha Moses - New York NY, US
Fabio Felix - Foxborough MA, US
Bruce Van Natta - Westfield IN, US
Antonio Fosco - North Reading MA, US
David P. Martin - Arlington MA, US
Simon F. Williams - Cambridge MA, US

International Classification:

A61F 2/12
A61F 2/00
A61B 17/00
A61L 27/36
A61L 27/50
A61L 27/58
A61L 27/18
B29C 35/02

Abstract:

Absorbable implants for breast surgery that conform to the breast parenchyma and surrounding chest wall have been developed. These implants support newly lifted breast parenchyma, and/or a breast implant. The implants have mechanical properties sufficient to support a reconstructed breast, and allow the in-growth of tissue into the implant as it degrades. The implants have a strength retention profile allowing the support of the breast to be transitioned from the implant to regenerated host tissue, without significant loss of support. Three-dimensional implants for use in minimally invasive mastopexy/breast reconstruction procedures are also described, that confer shape to a patient's breast. These implants are self-reinforced, can be temporarily deformed, implanted in a suitably dissected tissue plane, and resume their preformed three-dimensional shape. The implants are preferably made from poly-4-hydroxybutyrate (P4HB) and copolymers thereof. The implants have suture pullout strengths that can resist the mechanical loads exerted on the reconstructed breast.

US Patent:

20180209073, Jul 26, 2018

Filed:

Mar 19, 2018

Appl. No.:

15/924693

Inventors:

- Lexington MA, US
Fabio Felix - Foxborough MA, US
Bhavin Shah - Lowell MA, US
Matthew Bernasconi - Norwood MA, US
Said Rizk - Windham NH, US
David P. Martin - Arlington MA, US
Simon F. Williams - Cambridge MA, US

International Classification:

D01F 6/62
D01D 5/08
A61L 31/06
A61L 31/14
B29C 55/00
A61L 17/10
D01F 8/14
D02G 3/04
B29K 73/00
B29K 673/00
B29L 31/00

Abstract:

Resorbable multifilament yarns and monofilament fibers including poly-4-hydroxybutyrate and copolymers thereof with high tenacity or high tensile strength have been developed. The yarns and fibers are produced by cold drawing the multifilament yarns and monofilament fibers before hot drawing the yarns and fibers under tension at temperatures above the melt temperature of the polymer or copolymer. These yarns and fibers have prolonged strength retention in vivo making them suitable for soft tissue repairs where high strength and strength retention is required. The multifilament yarns have tenacities higher than 8.1 grams per denier, and in vivo, retain at least 65% of their initial strength at 2 weeks. The monofilament fibers retain at least 50% of their initial strength at 4 weeks in vivo. The monofilament fibers have tensile strengths higher than 500 MPa. These yarns and fibers may be used to make various medical devices for various applications.

US Patent:

20170216018, Aug 3, 2017

Filed:

Apr 17, 2017

Appl. No.:

15/489330

Inventors:

- Lexington MA, US
Emily Stires - Cambridge MA, US
Rebecca Holmes - North Reading MA, US
Said Rizk - Windham NH, US
Arikha Moses - New York NY, US
Fabio Felix - Foxborough MA, US
Bruce Van Natta - Westfield IN, US

International Classification:

A61F 2/12
A61F 2/00

Abstract:

Absorbable implants for breast surgery that conform to the breast parenchyma and surrounding chest wall have been developed. These implants support newly lifted breast parenchyma, and/or a breast implant. The implants have mechanical properties sufficient to support a reconstructed breast, and allow the in-growth of tissue into the implant as it degrades. The implants have a strength retention profile allowing the support of the breast to be transitioned from the implant to regenerated host tissue, without significant loss of support. Three-dimensional implants for use in minimally invasive mastopexy/breast reconstruction procedures are also described, that confer shape to a patient's breast. These implants are self-reinforced, can be temporarily deformed, implanted in a suitably dissected tissue plane, and resume their preformed three-dimensional shape. The implants are preferably made from poly-4-hydroxybutyrate (P4HB) and copolymers thereof. The implants have suture pullout strengths that can resist the mechanical loads exerted on the reconstructed breast.

US Patent:

20170081784, Mar 23, 2017

Filed:

Dec 5, 2016

Appl. No.:

15/368922

Inventors:

- Lexington MA, US
Fabio Felix - Foxborough MA, US
Bhavin Shah - Lowell MA, US
Matthew Bernasconi - Norwood MA, US
Said Rizk - Windham NH, US
David P. Martin - Arlington MA, US
Simon F. Williams - Sherborn MA, US

International Classification:

D01F 6/62
A61L 31/06
B29C 55/00
D02G 3/04
D01D 5/08
A61L 17/10
A61L 31/14

Abstract:

Resorbable multifilament yarns and monofilament fibers including poly-4-hydroxybutyrate and copolymers thereof with high tenacity or high tensile strength have been developed. The yarns and fibers are produced by cold drawing the multifilament yarns and monofilament fibers before hot drawing the yarns and fibers under tension at temperatures above the melt temperature of the polymer or copolymer. These yarns and fibers have prolonged strength retention in vivo making them suitable for soft tissue repairs where high strength and strength retention is required. The multifilament yarns have tenacities higher than 8.1 grams per denier, and in vivo, retain at least 65% of their initial strength at 2 weeks. The monofilament fibers retain at least 50% of their initial strength at 4 weeks in vivo. The monofilament fibers have tensile strengths higher than 500 MPa. These yarns and fibers may be used to make various medical devices for various applications.

US Patent:

20160166727, Jun 16, 2016

Filed:

Dec 10, 2015

Appl. No.:

14/964985

Inventors:

- Lexington MA, US
Fabio Felix - Foxborough MA, US
Bhavin Shah - Lowell MA, US
Matthew Bernasconi - Norwood MA, US
Said Rizk - Windham NH, US
David P. Martin - Arlington MA, US
Simon F. Williams - Sherborn MA, US

International Classification:

A61L 17/10
B29C 55/00
D01F 8/14
A61L 31/06
A61L 31/14

Abstract:

Resorbable multifilament yarns and monofilament fibers including poly-4-hydroxybutyrate and copolymers thereof with high tenacity or high tensile strength have been developed. The yarns and fibers are produced by cold drawing the multifilament yarns and monofilament fibers before hot drawing the yarns and fibers under tension at temperatures above the melt temperature of the polymer or copolymer. These yarns and fibers have prolonged strength retention in vivo making them suitable for soft tissue repairs where high strength and strength retention is required. The multifilament yarns have tenacities higher than 8.1 grams per denier, and in vivo, retain at least 65% of their initial strength at 2 weeks. The monofilament fibers retain at least 50% of their initial strength at 4 weeks in vivo. The monofilament fibers have tensile strengths higher than 500 MPa. These yarns and fibers may be used to make various medical devices for various applications.

US Patent:

20150223928, Aug 13, 2015

Filed:

Apr 23, 2015

Appl. No.:

14/694681

Inventors:

- Lexington MA, US
Emily Stires - Boston MA, US
Rebecca Marciante - North Reading MA, US
Said Rizk - Windham NH, US
Arika Moses - New York NY, US
Fabio Felix - Foxborough MA, US
Bruce Van Natta - Westfield IN, US

International Classification:

A61F 2/12
B29C 35/02
A61B 19/00
A61F 2/00
A61B 17/00

Abstract:

Absorbable implants for breast surgery that conform to the breast parenchyma and surrounding chest wall have been developed. These implants support newly lifted breast parenchyma, and/or a breast implant. The implants have mechanical properties sufficient to support a reconstructed breast, and allow the in-growth of tissue into the implant as it degrades. The implants have a strength retention profile allowing the support of the breast to be transitioned from the implant to regenerated host tissue, without significant loss of support. Three-dimensional implants for use in minimally invasive mastopexy/breast reconstruction procedures are also described, that confer shape to a patient's breast. These implants are self-reinforced, can be temporarily deformed, implanted in a suitably dissected tissue plane, and resume their preformed three-dimensional shape. The implants are preferably made from poly-4-hydroxybutyrate (P4HB) and copolymers thereof. The implants have suture pullout strengths that can resist the mechanical loads exerted on the reconstructed breast.