Dylan J. Taatjes - Boulder CO David J. Fenick - Washington DC Tad H. Koch - Boulder CO
Assignee:
University Technology Corporation - Boulder CO
International Classification:
A61K 3170
US Classification:
514 35, 514 25, 514 34, 536 64, 536 65
Abstract:
Monomeric and dimeric anti-cancer drug aldehyde conjugate compounds and pharmaceutically acceptable salts thereof. Specifically, monomeric and dimeric aldehyde conjugates of 1-2, dihetero-substituted anti-cancer drugs, including monomeric and dimeric aldehyde conjugates of anthracyclines, are provided. Also provided are pro-drugs which, after administration, release monomeric aldehyde conjugates. Further provided are pharmaceutical and therapeutic compositions containing anti-cancer drug aldehyde conjugates and methods of treating cancer using the aldehyde conjugates.
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