Chung Y. Lui - Lansdale PA Drazen Ostovic - Lansdale PA Ashok V. Katdare - Norristown PA Christine Stelmach - Tinton Falls NJ
Assignee:
Merck Co., Inc. - Rahway NJ
International Classification:
A61K 31535
US Classification:
5142315, 514252, 514255, 514311
Abstract:
This invention relates to a dry granulation capsule formulation of the HIV protease inhibitor, indinavir sulfate, which is useful in the treatment of AIDS, ARC or HIV infection. Processes for making the oral formulation are also disclosed.
Pharmaceutical Compositions Containing An Hiv Integrase Inhibitor And A Nonionic Surfactant
Sandra Robertson - Harleysville PA, US Maria Cruanes - Lansdale PA, US Sami karaborni - Lansdale PA, US Drazen Ostovic - Newbury Park CA, US Ashkan Kamali - Ask West Conshohacken PA, US Santipharp Panmai - North Wales PA, US
Pharmaceutical compositions comprise a therapeutically effective amount of an 8-hydroxy-1,6-naphthyridine-7-carboxamide of Formula (I), or a pharmaceutically acceptable salt thereof: and a nonionic surfactant; wherein R, R, Rand Qare defined herein. Compounds of Formula (I) are HIV integrase inhibitors, and the pharmaceutical compositions are useful for preventing or treating HIV infection or for preventing, treating, or delaying the onset of AIDS. The pharmaceutical compositions are typically administered orally, for example, in the form of capsules or tablets, and can provide good oral bioavailability. Methods for preparing encapsulated and tabletted forms of the pharmaceutical compositions are described.
David Boardman - Norristown PA, US Shyam Karki - Lansdale PA, US Aquiles Leyes - Schwenksville PA, US Drazen Ostovic - Newbury Park CA, US
International Classification:
A61K 31/59
US Classification:
514167000
Abstract:
This invention is related to a process for preparing a stabilized form of vitamin D which comprises the steps of: a) dissolving vitamin D in a solution that contains water and at least one surfactant to produce a mixture; b) spraying the mixture onto an inert carrier to produce a wet mass; and c) drying the wet mass obtain the stabilized form of vitamin D.
Liquid And Semi-Solid Pharmaceutical Formulations For Oral Administration Of A Substituted Amide
Andrey Peresypkin - Cranford NJ, US Eleni Dokou - Harleysville PA, US Craig McKelvey - Ambler PA, US Charles DeLuca - Royersford PA, US Laman Alani - Lansdale PA, US Todd Gibson - North Haven CT, US Danielle Euler - Souderton PA, US Santipharp Panmai - West Point PA, US W. Wuelfing - Schwenksville PA, US Thomas Gandek - Collegeville PA, US Drazen Ostovic - Newbury Park CA, US Timothy Rhodes - South Orange NJ, US Brian Hamilton - Lansdale PA, US
N-[1S,2S]-3-(4-chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl]-2-methyl-2-{[5-trifluoromethyl]pyridine-2-yl}oxy}propanamide (Compound I) has surprisingly improved solubility and bioavailability in a lipophilic vehicle comprising a pharmaceutically acceptable digestible oil, a surfactant, or a cosolvent, or a mixture of any two or more thereof. In one embodiment of the present invention are self-emulsifying or self-microemulsifying composition comprising 1) Compound I; 2) a surfactant having an HLB of 1 to 8; and 3) a surfactant having an HLB of over 8 to 20; and optionally, 4) a digestible oil and/or cosolvent and/or antioxidant or preservative.
Annette Bak - Watertown MA, US Drazen Ostovic - Newbury Park CA, US
International Classification:
A61K 31/19 C07C 57/03 C07C 57/10
US Classification:
514557, 562598, 562601
Abstract:
The present invention relates to a pharmaceutical co-crystal comprising an active pharmaceutical ingredient and a co-crystal agent having the structure R—C(═O)XH.
Anhydrous Alendronate Monosodium Salt Formulations
Gerald S. Brenner - Norristown PA Drazen Ostovic - Lansdale PA Earl R. Oberholtzer - Hatfield PA J. Eric Thies - Scotch Plains NJ
Assignee:
Merck & Co., Inc. - Rahway NJ
International Classification:
A61K 3166
US Classification:
514108
Abstract:
Disclosed is a method for treating and preventing bone loss in patients by administering a formulation of anhydrous alendronate sodium. Also described is a pharmaceutical doage form of said anhydrous alendronate sodium, being anhydrous 4-amino-1-hydroxy-butylidene-1,1-bisphosphonic acid, monosodium salt, in a pharmaceutically acceptable excipient.
Anhydrous Alendronate Monosodium Salt Formulations
Gerald S. Brenner - Norristown PA Drazen Ostovic - Lansdale PA Earl R. Oberholtzer - Hatfield PA J. Eric Thies - Scotch Plains NJ
Assignee:
Merck & Co., Inc. - Rahway NJ
International Classification:
A61K 3166
US Classification:
514108
Abstract:
Disclosed is a method for treating and preventing bone loss in patients by administering a formulation of anhydrous alendronate sodium. Also described is a pharmaceutical dosage form of said anhydrous alendronate sodium, being anhydrous 4-amino-1-hydroxy-butylidene-1,1-bisphosphonic acid, monosodium salt, in a pharmaceutically acceptable excipient.
Methods And Compositions For Treatment Of Pain Using Capsaicin
- Boston MA, US Peter D. Hanson - Bristol WI, US Gary F. Musso - Hopkinton MA, US Drazen Ostovic - Redwood City CA, US Randall Stevens - Rockport MA, US
International Classification:
A61K 31/167 A61P 19/02 A61K 9/00 A61F 7/10
Abstract:
The invention provides methods and compositions for treatment of pain, such as joint pain, using capsaicin in a procedure that attenuates transient burning sensation experienced by patients due to capsaicin administration. The methods desirably provide relief from joint pain, such as osteoarthritic knee joint pain, for an extended duration, such as at least about 3 months, 6 months, 9 months, or 1 year. To attenuate the adverse side effect of a transient burning sensation caused by capsaicin-induced neuronal excitation, the methods utilize a cooling article, such as a material wrap cooled via a circulating fluid, to reduce the temperature of tissue to be exposed to capsaicin to within a certain range for certain durations of time, optionally in combination with administering a local anesthetic agent, resulting in the substantial reduction or even elimination of transient burning sensation caused by capsaicin.
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