Despina C Siolas

US Patent:

20080213861, Sep 4, 2008

Filed:

Aug 20, 2007

Appl. No.:

11/894676

Inventors:

Gregory J. Hannon - Huntington NY, US
Patrick J. Paddison - Northport NY, US
Despina C. Siolas - Mattituck NY, US

International Classification:

C12N 9/18

US Classification:

435197

Abstract:

The present invention provides methods for attenuating gene expression in a cell, especially in a mammalian cell, using gene-targeted double stranded RNA (dsRNA), such as a hairpin RNA. The dsRNA contains a nucleotide sequence that hybridizes under physiologic conditions of the cell to the nucleotide sequence of at least a portion of the gene to be inhibited (the “target” gene).

US Patent:

20060135456, Jun 22, 2006

Filed:

Nov 23, 2004

Appl. No.:

10/997086

Inventors:

Gregory Hannon - Huntington NY, US
Patrick Paddison - Northport NY, US
Despina Siolas - Mattituck NY, US

International Classification:

A61K 48/00

US Classification:

514044000

Abstract:

The present invention provides methods for attenuating gene expression in a cell, especially in a mammalian cell, using gene-targeted double stranded RNA (dsRNA), such as a hairpin RNA. The dsRNA contains a nucleotide sequence that hybridizes under physiologic conditions of the cell to the nucleotide sequence of at least a portion of the gene to be inhibited (the “target” gene).