Dennis F Michiel

US Patent:

8415456, Apr 9, 2013

Filed:

Oct 29, 2010

Appl. No.:

12/915363

Inventors:

David F. Nellis - Frederick MD, US
Dennis F. Michiel - Hagerstown MD, US

Assignee:

The United States of America, as represented by the Secretary, Department of Health and Human Services - Washington DC

International Classification:

C07K 14/54
A61K 38/20
A61K 45/00

US Classification:

530351, 514 11, 424 852

Abstract:

The invention provides IL-15 amino acid sequences with amino acid substitutions that reduce or eliminate deamidation of IL-15 and degradation by-products. The invention also provides DNA sequences that encode the substituted amino acid sequences, a pharmaceutical composition comprising the substituted IL-15 amino acid sequence and a pharmaceutically acceptable carrier, and a method of treating a condition in a mammalian host comprising administering to the host the substituted IL-15 amino acid sequence or the pharmaceutical composition including the substituted IL-15 amino acid sequence in an amount effective to treat the condition in the host.

US Patent:

58372474, Nov 17, 1998

Filed:

Jun 16, 1995

Appl. No.:

8/491204

Inventors:

Joost J. Oppenhelm - Bethesda MD
Dennis Michiel - Funkstown MD
Oleg Chertov - Frederick MD
Dennis D. Taub - Thurmont MD
Luoling Xu - London, CA
Ji Ming Wang - Frederick MD
William J. Murphy - Frederick MD

Assignee:

United States of America as represented by the Public Health Service
National Institutes of Health - Washington DC

International Classification:

A61K 3900

US Classification:

4241851

Abstract:

Chemotactic activity of defensins and CAP37 is disclosed. Methods of treatment associated with such activity and compositions for such treatment are also provided.