Denis G Wirtz

US Patent:

20040067599, Apr 8, 2004

Filed:

Nov 20, 2003

Appl. No.:

10/450194

Inventors:

Joseph Katz - Baltimore MD, US
Denis Wirtz - Washington DC, US

International Classification:

G01N033/543
C12Q001/68
C07K001/00

US Classification:

436/518000, 435/006000, 530/413000

Abstract:

A Repeated Classification Procedure (RCP) for the rapid separation, identification, classification, and quantitation of proteins in a mixture of proteins utilizes general-motif antibodies which typically bind to a plurality of proteins in a mixture which have a common motif or are homologs in some respect. By repeatedly using general-motif antibodies or using general-motif antibodies in conjunction with specific antibodies, a pattern of binding can be produced which uniquely identifies proteins of interest. By using immobilized general-motif antibodies to effect separation, the identification, classification, and quantitation of proteins in a sample can be use to characterize the protein synthesis pattern of disease states. Quantitation of protein in a sample can be determined based on the movement of very small beads with bound protein in a magnetic field, wherein larger quantities of bound protein causes the beads to travel relatively smaller distances or at relatively slower rates.

US Patent:

20070212681, Sep 13, 2007

Filed:

Aug 30, 2005

Appl. No.:

11/215136

Inventors:

Benjamin Shapiro - Washington DC, US
Pamela Abshire - Silver Spring MD, US
Elisabeth Smela - Silver Spring MD, US
Denis Wirtz - Washington DC, US

International Classification:

C12Q 1/70
C12Q 1/68
C12M 3/00

US Classification:

435005000, 435006000, 435287200

Abstract:

Methods and compositions for the reliable detection of pathogens are presented. The invention uses cells as novel pathogen detection agents, exploiting pathogen-specific pathways and apoptosis.

US Patent:

20080166414, Jul 10, 2008

Filed:

Jan 28, 2005

Appl. No.:

10/587512

Inventors:

Justin Hanes - Baltimore MD, US
Michelle Rose Dawson - Arlington MA, US
Denis Wirtz - Washington DC, US
Jie Fu - Baltimore MD, US
Eric Mark Krauland - Somerville MA, US

Assignee:

Johns Hopkins University - Baltimore MD

International Classification:

A61K 9/14
A61K 31/7088
A61K 38/00
C12N 5/02
A61M 15/00

US Classification:

424490, 514 2, 514 44, 435375, 12820315

Abstract:

The invention generally relates to polymeric particles suitable for transporting bioactive agents across mucosal barriers. The invention also relates to methods of making and using those polymeric particles.

US Patent:

20100253328, Oct 7, 2010

Filed:

Mar 9, 2010

Appl. No.:

12/720025

Inventors:

Alfredo A. Celedon - Baltimore MD, US
Sean X. Sun - Baltimore MD, US
Gregory Bowman - Pikesville MD, US
Denis Wirtz - Washington DC, US
Peter Searson - Baltimore MD, US

Assignee:

Johns Hopkins University - Baltimore MD

International Classification:

G01B 7/30

US Classification:

32420725

Abstract:

A system and a method for determining the torque imposed on a filament, such as a single DNA strand or macromolecule, using a magnetic probe and an imaging device.

US Patent:

20130071003, Mar 21, 2013

Filed:

Jun 22, 2012

Appl. No.:

13/530772

Inventors:

Denis Gaston WIRTZ - Washington DC, US
Pei-Hsun Wu - Towson MD, US
Shyam Bharat Khatau - Baltimore MD, US
Wei-Chiang Chen - Baltimore MD, US
Jude Marvin George Phillip, JR. - Washington DC, US
Zev Ari Binder - Baltimore MD, US
Yiider Tseng - Gainesville FL, US

Assignee:

University of Florida - Gainesville FL
The Johns Hopkins University - Baltimore MD

International Classification:

G06K 9/00

US Classification:

382133

Abstract:

A diagnostic device includes a microscope configured to obtain image data on a plurality of cells and a computing device. The computing device is configured to receive the image data, identify at least a portion of each of the plurality of cells based on the received image data, determine at least one of a value of a morphological parameter for each identified at least a portion of the plurality of cells or a relative organization among the identified at least a portion of the plurality of cells, and calculate statistics for the plurality of cells based on the at least one of the determined values of the morphological parameter or the determined relative organization, the statistics including information suitable for distinguishing metastatic cells from non-metastatic cells. The diagnostic device further includes an output device configured to output the statistics for diagnosis.

US Patent:

20220251222, Aug 11, 2022

Filed:

May 29, 2020

Appl. No.:

17/614840

Inventors:

- Baltimore MD, US
Denis Gaston Wirtz - Baltimore MD, US
Huilin Yang - Baltimore MD, US
Wentao Wang - Baltimore MD, US
Michelle Karl - Baltimore MD, US

International Classification:

C07K 16/28
A61P 35/00

Abstract:

The present disclosure relates to bispecific binding agents with a novel format that bind IL-6Rα and IL-8R. The present disclosure also relates to methods of using such bispecific binding agents in the treatment of cancer.

US Patent:

20220251223, Aug 11, 2022

Filed:

May 29, 2020

Appl. No.:

17/614864

Inventors:

- Baltimore MD, US
Denis Gaston Wirtz - Baltimore MD, US
Huilin Yang - Baltimore MD, US
Wentao Wang - Baltimore MD, US
Michelle Karl - Baltimore MD, US

International Classification:

C07K 16/28

Abstract:

Provided herein are novel bispecific binding agents and methods of constructing and expressing the same. The methods of constructing the bispecific binding agent generally describes a combination of a knobs-in-holes assembly strategy and a single-chain Fab expression approach to generate a modular bispecific binding platform.

US Patent:

20210052507, Feb 25, 2021

Filed:

Sep 4, 2020

Appl. No.:

17/012976

Inventors:

- Baltimore MD, US
Michelle R. Dawson - Atlanta GA, US
Denis Wirtz - Washington DC, US
Jie Fu - Baltimore MD, US
Eric M. Krauland - Lebanon NH, US

International Classification:

A61K 9/51
A61K 9/00
A61K 9/16
A61K 9/50
B82Y 5/00
A61K 47/54
A61K 47/69
A61K 48/00

Abstract:

The invention generally relates to polymeric particles suitable for transporting bioactive agents across mucosal barriers. The invention also relates to methods of making and using those polymeric particles.