Deborah L Damm from Basalt, CO, age 71

Us Patents

Protease Inhibitor Peptides
view source
US Patent:

6376648, Apr 23, 2002
Filed:

Jan 21, 1999
Appl. No.:

09/234874
Inventors:

R. Tyler White - Fremont CA
Deborah Damm - Redwood City CA
David D. Lesikar - Palo Alto CA
Kathleen McFadden - Mountain View CA
Brett L. Garrick - Palo Alto CA
Assignee:

Scios Nova, Inc. - Mountain View CA
International Classification:

C07K 1481
US Classification:

530324, 514 12
Abstract:

Analogues of the Kunitz Protease Inhibitor (KPI) domain of amyloid precursor protein bind to and inhibit activity of serine proteases, including kallikrein, plasmin and coagulation factors such as factors VIIa, IXa, Xa, XIa, and XIIa. Pharmaceutical compositions containing the KPI analogues, along with methods for using such compositions, are useful for ameliorating and treating clinical conditions associated with increased serine protease activity, such as blood loss related to cardiopulmonary bypass surgery. Nucleic acid sequences encoding these analogues and systems for expression of the peptides of the invention are provided.

Protease Inhibitor Peptides
view source
US Patent:

6613890, Sep 2, 2003
Filed:

Jan 21, 1999
Appl. No.:

09/234873
Inventors:

R. Tyler White - Fremont CA
Deborah Damm - Redwood City CA
David D. Lesikar - Palo Alto CA
Kathleen McFadden - Mountain View CA
Brett L. Garrick - Palo Alto CA
Assignee:

Scios, Inc. - Sunnyvale CA
International Classification:

C07H 2104
US Classification:

536 231, 530324, 536 235
Abstract:

Analogues of the Kunitz Protease Inhibitor (KPI) domain of amyloid precursor protein bind to and inhibit activity of serine proteases, including kallikrein, plasmin and coagulation factors such as factors VIIa, IXa, Xa, XIa, and XIIa. Pharmaceutical compositions containing the KPI analogues, along with methods for using such compositions, are useful for ameliorating and treating clinical conditions associated with increased serine protease activity, such as blood loss related to cardiopulmonary bypass surgery. Nucleic acid sequences encoding these analogues and systems for expression of the peptides of the invention are provided.

Methods For Detection And Use Of Differentially Expressed Genes In Disease States
view source
US Patent:

6709855, Mar 23, 2004
Filed:

Dec 15, 1999
Appl. No.:

09/461912
Inventors:

Lawrence W. Stanton - Redwood City CA
R. Tyler White - Fremont CA
Deborah L. Damm - Redwood City CA
John A. Lewicki - Los Gatos CA
Alison Joly - San Mateo CA
George F. Schreiner - Los Altos Hills CA
Assignee:

Scios, Inc. - Fremont CA
International Classification:

C12M 134
US Classification:

4352831, 4352872, 435 6, 536 243, 536 2433, 536 2431, 536 231
Abstract:

The present invention relates to methods and compositions for the detection, diagnosis, prevention and treatment of a disease, specifically cardiac, kidney or inflammatory disease, and related disorders. The present invention also relates to compositions and methods useful in the diagnosis, prevention and therapeutic treatment of a disease, specifically cardiac, kidney or inflammatory disease. Specifically, methods and compositions are provided for the diagnostic evaluation and prognosis of conditions involving a disease, specifically cardiac, kidney or inflammatory disease, for the identification of subjects exhibiting a predisposition to such conditions, for modulating the effect of these differentially expressed genes, for monitoring patients undergoing clinical evaluation for the prevention and treatment of a disease, specifically cardiac, kidney or inflammatory disease, and its disorders, and for monitoring the efficacy of compounds used in clinical trials.

Protease Inhibitor Peptides
view source
US Patent:

6906033, Jun 14, 2005
Filed:

Feb 19, 2002
Appl. No.:

10/076604
Inventors:

R. Tyler White - Fremont CA, US
Deborah Damm - Redwood City CA, US
David D. Lesikar - Palo Alto CA, US
Kathleen McFadden - Mountain View CA, US
Brett L. Garrick - Palo Alto CA, US
Assignee:

SCIOS NOVA, Inc. - Sunnyvale CA
International Classification:

A61K038/16
C07K014/81
C07H021/04
US Classification:

514 12, 435 692, 530324, 536 231
Abstract:

Analogues of the Kunitz Protease Inhibitor (KPI) domain of amyloid precursor protein bind to and inhibit activity of serine proteases, including kallikrein, plasmin and coagulation factors such as factors VIIa, IXa, Xa, XIa, and XIIa. Pharmaceutical compositions containing the KPI analogues, along with methods for using such compositions, are useful for ameliorating and treating clinical conditions associated with increased serine protease activity, such as blood loss related to cardiopulmonary bypass surgery. Nucleic acid sequences encoding these analogues and systems for expression of the peptides of the invention are provided.

Protease Inhibitor Peptides
view source
US Patent:

59622660, Oct 5, 1999
Filed:

Apr 2, 1997
Appl. No.:

8/829876
Inventors:

R. Tyler White - Fremont CA
Deborah Damm - Redwood City CA
David D. Lesikar - Palo Alto CA
Kathleen McFadden - Mountain View CA
Brett L. Garrick - Palo Alto CA
Assignee:

Scios, Inc. - Mountain View CA
International Classification:

C12P 2106
C12N 120
A61K 3800
C07H 2102
US Classification:

435 692
Abstract:

Analogues of the Kunitz Protease Inhibitor (KPI) domain of amyloid precursor protein bind to and inhibit activity of serine proteases, including kallikrein, plasmin and coagulation factors such as factors VIIa, IXa, Xa, XIa, and XIIa. Pharmaceutical compositions containing the KPI analogues, along with methods for using such compositions, are useful for ameliorating and treating clinical conditions associated with increased serine protease activity, such as blood loss related to cardiopulmonary bypass surgery. Nucleic acid sequences encoding these analogues and systems for expression of the peptides of the invention are provided.