David A Benfield

Author:

David A. Benfield

ISBN #:

0306455196

US Patent:

6498008, Dec 24, 2002

Filed:

Dec 18, 2000

Appl. No.:

09/740156

Inventors:

James E. Collins - White Bear Lake MN
David A. Benfield - Brookings SD
Danny W. Chladek - St. Joseph MO
Louis L. Harris - St. Joseph MO
David E. Gorcyca - St. Joseph MO

Assignee:

Regents of the University of Minnesota - Minneapolis MN
South Dakota State University - Brookings SD
Boehringer Ingelheim Vetmedica, Inc. - St. Joseph MO

International Classification:

C12Q 170

US Classification:

435 5, 435 71, 435 792, 435 795

Abstract:

The invention includes a vaccine and sera for treatment of Mystery Swine Disease (MSD), a method for producing the vaccine, methods for diagnosis of MSD, a viral agent that will mimic âmystery swine diseaseâ and antibodies to the viral agent useful in diagnosis and treatment of MSD. The serum contains mammalian antibodies which are effective in treating MSD.

US Patent:

6855315, Feb 15, 2005

Filed:

Oct 28, 2002

Appl. No.:

10/281884

Inventors:

James E. Collins - White Bear Lake MN, US
David A. Benfield - Brookings SD, US
Danny W. Chladek - St. Joseph MO, US
Louis L. Harris - St. Joseph MO, US
David E. Gorcyca - St. Joseph MO, US

Assignee:

Regents of the University of Minnesota - Minneapolis MN
South Dakota State University - Brookings SD
Boehringer Ingelheim Vetmedica, Inc. - St. Joseph MO

International Classification:

A61K039/395

US Classification:

4241301, 4241591, 435332, 435975

Abstract:

The invention includes a vaccine and sera for treatment of Mystery Swine Disease (MSD), a method for producing the vaccine, methods for diagnosis of MSD, a viral agent that will mimic “mystery swine disease” and antibodies to the viral agent useful in diagnosis and treatment of MSD. The serum contains mammalian antibodies which are effective in treating MSD.

US Patent:

6982160, Jan 3, 2006

Filed:

May 6, 2004

Appl. No.:

10/839877

Inventors:

James E. Collins - White Bear Lake MN, US
David A. Benfield - Brookings SD, US
Danny W. Chladek - St. Joseph MO, US
Louis L. Harris - St. Joseph MO, US
David E. Gorcyca - St. Joseph MO, US

Assignee:

Boehringer Ingelheim Vetmedica, Inc. - St. Joseph MO

International Classification:

C12N 7/00

US Classification:

4352351, 435236, 435237

Abstract:

The invention includes kits for producing and using immunogenic compositions that include swine infertility and respiratory virus. The invention also includes vaccines and sera for treatment of Mystery Swine Disease (MSD), a method for producing the vaccine, methods for diagnosis of MSD, a viral agent that will mimic “mystery swine disease” and antibodies to the viral agent useful in diagnosis and treatment of MSD. The serum contains mammalian antibodies which are effective in treating MSD.

US Patent:

7264804, Sep 4, 2007

Filed:

May 12, 2005

Appl. No.:

11/127491

Inventors:

James E. Collins - White Bear Lake MN, US
David A. Benfield - Brookings SD, US
Danny W. Chladek - St. Joseph MO, US
Louis L. Harris - St. Joseph MO, US
David E. Gorcyca - St. Joseph MO, US

Assignee:

Boehringer Ingleheim Vetmedica, Inc. - St. Josesph MO
Regents of the University of Minnesota - Minneapolis MN
South Dakota State University - Brookings SD

International Classification:

A61K 39/395

US Classification:

4241301, 4241591, 435 71

Abstract:

The invention includes kits for producing and using immunogenic compositions that include swine infertility and respiratory virus. The invention also includes vaccines and sera for treatment of Mystery Swine Disease (MSD), a method for producing the vaccine, methods for diagnosis of MSD, a viral agent that will mimic “mystery swine disease” and antibodies to the viral agent useful in diagnosis and treatment of MSD. The serum contains mammalian antibodies which are effective in treating MSD.

US Patent:

58468056, Dec 8, 1998

Filed:

Sep 30, 1994

Appl. No.:

8/316529

Inventors:

James E. Collins - White Bear Lake MN
David A. Benfield - Brookings SD
Danny W. Chladek - St. Joseph MO
Louis L. Harris - St. Joseph MO
David E. Gorcyca - St. Joseph MO

Assignee:

Boehringer Ingelheim Animal Health, Inc. - Ridgefield CT
South Dakota State University - Brookings SD
Regents of University of Minnesota - Minneapolis MN

International Classification:

C12N 700
C12N 702
C12N 704
C12N 708

US Classification:

4352351

Abstract:

The invention includes a vaccine and sera for treatment of Mystery Swine Disease (MSD), a method for producing the vaccine, methods for diagnosis of MSD, a viral agent that will mimic "mystery swine disease" and antibodies to the viral agent useful in diagnosis and treatment of MSD. The serum contains mammalian antibodies which are effective in treating MSD.

US Patent:

56838654, Nov 4, 1997

Filed:

Feb 24, 1995

Appl. No.:

8/394226

Inventors:

James E. Collins - White Bear Lake MN
David A. Benfield - Brookings SD
Danny W. Chladek - St. Joseph MO
Louis L. Harris - St. Joseph MO
David E. Gorcyca - St. Joseph MO

Assignee:

South Dakota State University - Brookings SD
Regents of the University of Minnesota - Minneapolis MN

International Classification:

C12Q 170

US Classification:

435 5

Abstract:

The method of diagnosis of Mystery Swine Disease (MSD) is carried out with polyclonal or monoclonal antibody sera. Either the antibody sera or the biopsied tissue homogenate may be immobilized by contact by contact with a polystyrene surface or with a surface of another polymer for immobilizing protein. Preferably the monoclonal antibody is produced by a murine derived hybrid cell line wherein the antibody is an IgG or IgM type immunoglobulin. Example monoclonal antibodies to the infectious agent for SIRS are monoclonal antibody SDOW 12 and SDOW 17.

US Patent:

56774290, Oct 14, 1997

Filed:

Jun 7, 1995

Appl. No.:

8/488286

Inventors:

David A. Benfield - Brookings SD

Assignee:

South Dakota State University - Brookings SD

International Classification:

C07K 1610

US Classification:

5303883

Abstract:

Monoclonal antibody sera can be produced by hybridoma technique. After immunization of a mouse, pig, rat, rabbit or other appropriate species with Mystery Swine Disease (MSD) containing cell culture lysate, the spleen of the animal can be removed and converted into a whole cell preparation. Preferably the monoclonal antibody is produced by a murine derived hybrid cell line wherein the antibody is an IgG or IgM type immunoglobulin. Example monoclonal antibodies to the infectious agent for SIRS are monoclonal antibody SDOW 12 and SDOW 17.

US Patent:

6110468, Aug 29, 2000

Filed:

Sep 11, 1997

Appl. No.:

8/927786

Inventors:

James E. Collins - White Bear Lake MN
David A. Benfield - Brookings SD
Danny W. Chladek - St. Joseph MO
Louis L. Harris - St. Joseph MO
David E. Gorcyca - St. Joseph MO

Assignee:

Regents of the University of Minnesota - Minneapolis MN
South Dakota State University - Brookings SD
Boechringer Ingelheim Vetmedica, Inc. - St. Joseph MO

International Classification:

A61K 3912
C12N 708
C12N 700
C12P 2106

US Classification:

4242041

Abstract:

The invention includes a vaccine and sera for treatment of Mystery Swine Disease (MSD), a method for producing the vaccine, methods for diagnosis of MSD, a viral agent that will mimic "mystery swine disease" and antibodies to the viral agent useful in diagnosis and treatment of MSD. The serum contains mammalian antibodies which are effective in treating MSD.