Daryl W Grummitt

US Patent:

20120255373, Oct 11, 2012

Filed:

May 23, 2012

Appl. No.:

13/506892

Inventors:

John S. Foster - Santa Barbara CA, US
Daryl W. Grummitt - Santa Barbara CA, US
John C. Harley - Santa Barbara CA, US
James P. Linton - San Diego CA, US
Jaquelin K. Spong - Falls Church VA, US
Douglas L. Thompson - Goleta CA, US

Assignee:

Owl biomedical, Inc - Goleta CA
Innovative Micro Technology - Goleta CA

International Classification:

G01N 1/28

US Classification:

7386321

Abstract:

A disposable cartridge is described which is equipped with a plurality of microfabricated particle sorting structures. The disposable cartridge may include passageways which connect fluid reservoirs in the cartridge with corresponding microfluidic passageways on the particle sorting structure. A flexible gasket may prevent leakages and allow the fluid to cross the gasket barrier through a plurality of holes in the gasket, allowing fluid to be transferred from the reservoirs to the microfabricated particle sorting structures. The plurality of particle sorting structures may be arranged in the disposable cartridge in order to perform multiple separation operations, such as a sequential or parallel sorting operation.

US Patent:

20140034555, Feb 6, 2014

Filed:

Aug 1, 2012

Appl. No.:

13/507830

Inventors:

John S. Foster - Santa Barbara CA, US
Daryl W. Grummitt - Santa Barbara CA, US

Assignee:

Owl biomedical, Inc. - Goleta CA

International Classification:

B07B 1/00

US Classification:

209233

Abstract:

A MEMS-based particle manipulation system which uses a particle manipulation stage and a plurality of laser interrogation regions. The laser interrogation regions may be used to assess the effectiveness or accuracy of the particle manipulation stage. In one exemplary embodiment, the particle manipulation stage is a microfabricated, flap-type fluid valve, which sorts a target particle from non-target particles in a fluid stream. The laser interrogation stages are disposed in the microfabricated fluid channels at the input and output of the flap-type sorting valve. The laser interrogation regions may be used to assess the effectiveness or accuracy of the sorting, and to control or adjust sort parameters during the sorting process.

US Patent:

20120190104, Jul 26, 2012

Filed:

Jan 23, 2012

Appl. No.:

13/374898

Inventors:

John S. Foster - Santa Barbara CA, US
Daryl W. Grummitt - Santa Barbara CA, US
John C. Harley - Santa Barbara CA, US
Jaquelin K. Spong - Falls Church VA, US
Kimberly L. Turner - Santa Barbara CA, US

Assignee:

Innovative Micro Technology - Goleta CA

International Classification:

C12M 1/34
B01L 3/00

US Classification:

4352887, 422503

Abstract:

A MEMS-based system and a method are described for separating a target particle from the remainder of a fluid stream. The system makes use of a unique, microfabricated movable structure formed on a substrate, which moves in a rotary fashion about one or more fixed points, which are all located on one side of the axis of motion. The movable structure is actuated by a separate force-generating apparatus, which is entirely separate from the movable structure formed on its substrate. This allows the movable structure to be entirely submerged in the sample fluid.

US Patent:

20120190105, Jul 26, 2012

Filed:

Jan 23, 2012

Appl. No.:

13/374899

Inventors:

John S. Foster - Santa Barbara CA, US
Daryl W. Grummitt - Santa Barbara CA, US
John C. Harley - Santa Barbara CA, US
James P. Linton - San Diego CA, US
Jaquelin K. Spong - Falls Church VA, US

Assignee:

Owl biomedical, Inc. - Goleta CA
Innovative Micro Technology - Goleta CA

International Classification:

C12M 1/34
B01L 3/00

US Classification:

4352887, 422554

Abstract:

A disposable cartridge is described which is compatible with a MEMS particle sorting device. The disposable cartridge may include passageways which connect fluid reservoirs in the cartridge with corresponding microfluidic passageways on the MEMS chip. A flexible gasket may prevent leakages and allow the fluid to cross the gasket barrier through a plurality of holes in the gasket. Vents and septums may also be included to allow air to escape and fluids to be inserted by hypodermic needle. A MEMS-based particle sorting system using the disposable cartridge is also described.

US Patent:

20220260480, Aug 18, 2022

Filed:

Apr 8, 2022

Appl. No.:

17/716007

Inventors:

John S. Foster - New Orleans LA, US
Mark A. Naivar - Santa Barbara CA, US
Kevin E. Shields - Santa Barbara CA, US
Daryl W. Grummitt - Santa Barbara CA, US
Timothy J. Wilt - Goleta CA, US
Lily Li - Santa Barbara CA, US

International Classification:

G01N 15/14
B07C 5/342
B01L 3/00

Abstract:

A MEMS-based particle manipulation system which uses a particle manipulation stage and optical confirmation of the manipulation. The optical confirmation may be camera-based, and may be used to assess the effectiveness or accuracy of the particle manipulation stage. In one exemplary embodiment, the particle manipulation stage is a microfabricated, fluid valve, which sorts a target particle from non-target particles in a fluid stream. The optical confirmation stage is disposed in the microfabricated fluid channels at the input and output of the microfabricated sorting valve. Deep learning techniques are brought to bear on the camera output to increase speed, accuracy and reliability.

US Patent:

20190360915, Nov 28, 2019

Filed:

Jun 22, 2019

Appl. No.:

16/449370

Inventors:

- Goleta CA, US
Mark A. NAIVAR - Goleta CA, US
Kevin E. SHIELDS - Santa Barbara CA, US
Daryl W. GRUMMITT - Santa Barbara CA, US
Lily LI - Santa Barbara CA, US
Daryl W. GRUMMITT - Goleta CA, US

Assignee:

Owl biomedical, Inc. - Goleta CA

International Classification:

G01N 15/14
B07C 5/342
B01L 3/00

Abstract:

A MEMS-based particle manipulation system which uses a particle manipulation stage and optical confirmation of the manipulation. The optical confirmation may be camera-based, and may be used to assess the effectiveness or accuracy of the particle manipulation stage. In one exemplary embodiment, the particle manipulation stage is a microfabricated, fluid valve, which sorts a target particle from non-target particles in a fluid stream. The optical confirmation stage is disposed in the microfabricated fluid channels at the input and output of the microfabricated sorting valve. Deep learning techniques are brought to bear on the camera output to increase speed, accuracy and reliability.

US Patent:

20170327783, Nov 16, 2017

Filed:

May 11, 2016

Appl. No.:

15/151518

Inventors:

Daryl GRUMMITT - Santa Barbara CA, US
John S. FOSTER - Santa Barbara CA, US

Assignee:

Owl biomedical, Inc. - Goleta CA

International Classification:

C12M 1/00
G01N 15/14
G01N 15/14
G01N 15/14
G01N 15/10

Abstract:

A particle manipulation system uses a MEMS-based, microfabricated particle manipulation device which has an inlet channel, output channels, and a movable member formed on a substrate. The movable member moves parallel to the fabrication plane, as does fluid flowing in the inlet channel. The movable member separates a target particle from the rest of the particles, diverting it into an output channel. The target particles may be identified by a marker-free signal such as axial light loss to identify highly pigmented particles.

US Patent:

20160082480, Mar 24, 2016

Filed:

Nov 20, 2015

Appl. No.:

14/947947

Inventors:

- Goleta CA, US
Daryl W. GRUMMITT - Santa Barbara CA, US

Assignee:

Owl biomedical, Inc. - Goleta CA

International Classification:

B07C 5/342
G01N 15/14

Abstract:

A MEMS-based particle manipulation system which uses a particle manipulation stage and a plurality of laser interrogation regions. The laser interrogation regions may be used to assess the effectiveness or accuracy of the particle manipulation stage. In one exemplary embodiment, the particle manipulation stage is a microfabricated, flap-type fluid valve, which sorts a target particle from non-target particles in a fluid stream. The laser interrogation stages are disposed in the microfabricated fluid channels at the input and output of the flap-type sorting valve. The laser interrogation regions may be used to assess the effectiveness or accuracy of the sorting, and to control or adjust sort parameters during the sorting process.