Daniel Peter Sipple

US Patent:

20190175495, Jun 13, 2019

Filed:

May 12, 2017

Appl. No.:

16/300660

Inventors:

- Saint Paul MN, US
Daniel Sipple - Saint Paul MN, US
James Segermark - Saint Paul MN, US

International Classification:

A61K 9/00
A61K 31/327
A61K 31/738
C12N 9/08

Abstract:

A hydrogel-based biological delivery vehicle used to effectively deliver drug and biological material to tissue or organ sites. More specifically, a hydrogel binding matrix having a biopolymer backbone containing carboxyl groups. Tyramine may be substituted for at least a portion of the carboxyl groups, so that, when hydrogen peroxide is added, it causes creation of covalent bonds between tyramine molecules and cross-links the hydrogel binding matrix, thereby enabling the hydrogel binding matrix to transition from liquid to gel state. The hydrogel binding matrix, in its liquid form, is capable of encapsulating drug reservoirs to create a homogenous liquid with evenly distributed particles containing drugs or target molecules. As the hydrogel binding matrix solidifies into a gel state, the newly created cross-links do not disrupt or react with the drugs or target molecules contained within the drug reservoirs. This hydrogel-based biological delivery vehicle can be used in several medical applications.