Daniel Lew Kraft

US Patent:

7902121, Mar 8, 2011

Filed:

May 27, 2004

Appl. No.:

10/856185

Inventors:

Daniel Shin-Yu Chen - Burlingame CA, US
Yoav Soen - Palo Alto CA, US
Daniel Lewis Kraft - Stanford CA, US
Patrick O. Brown - Palo Alto CA, US
Mark Davis - Atherton CA, US

Assignee:

The Board of Trustees of the Leland Stanford Junior University - Palo Alto CA

International Classification:

C40B 20/04
C07H 21/04

US Classification:

506 4, 506 2, 506 3, 506 33, 506 35, 4352863, 4352831, 4353052

Abstract:

T cells are profiled with respect to their expression of antigen receptor. The cells are arrayed on a planar or three-dimensional substrate through binding to immobilized or partially diffused MHC-antigen complexes. The cells may further be characterized with respect to their ability to respond to external stimulus in the microenvironment. External stimuli include cell-cell interactions, response to factors, and the like.

US Patent:

8002733, Aug 23, 2011

Filed:

Feb 14, 2007

Appl. No.:

11/675035

Inventors:

Daniel Kraft - Stanford CA, US
James Hole - Burlingame CA, US

International Classification:

A61M 1/00
A61M 25/01
A61M 5/00
A61M 5/31
A61M 31/00
A61B 10/02
A61B 17/14
A61B 17/32

US Classification:

604 35, 604239, 604500, 600565, 600566, 600568, 606 86 R, 606167, 606170, 606180

Abstract:

Device and method for rapid extraction of body tissue from an enclosed body cavity. Hollow entry cannula with optional core element provides entry into body tissue space such as bone marrow. Aspiration cannula is inserted through cannula into body tissue and is manipulated to advance directionally through body cavity. Optional stylet within aspiration cannula aids in advancing aspiration cannula through body tissue and is removed to facilitate extraction of body tissue through the aspiration cannula. Inlet openings near distal tip of aspiration cannula allow tissue aspiration, with negative pressure source at proximal end of aspiration cannula providing controlled negative pressure. Aspiration cannula may be withdrawn and its path adjusted for multiple entries through the same entry point, following different paths through tissue space for subsequent aspiration of more tissue.

US Patent:

8109919, Feb 7, 2012

Filed:

Feb 14, 2007

Appl. No.:

11/675031

Inventors:

Daniel Kraft - Stanford CA, US
James Hole - Burlingame CA, US

International Classification:

A61M 31/00
A61M 1/00
A61M 25/01

US Classification:

604522, 604 35, 604239, 604500

Abstract:

Device and method for rapid extraction of body tissue from an enclosed body cavity. Hollow entry cannula with optional core element provides entry into body tissue space such as bone marrow. Aspiration cannula is inserted through cannula into body tissue and is manipulated to advance directionally through body cavity. Optional stylet within aspiration cannula aids in advancing aspiration cannula through body tissue and is removed to facilitate extraction of body tissue through the aspiration cannula. Inlet openings near distal tip of aspiration cannula allow tissue aspiration, with negative pressure source at proximal end of aspiration cannula providing controlled negative pressure. Aspiration cannula may be withdrawn and its path adjusted for multiple entries through the same entry point, following different paths through tissue space for subsequent aspiration of more tissue.

US Patent:

8043253, Oct 25, 2011

Filed:

Feb 14, 2007

Appl. No.:

11/675019

Inventors:

Daniel Kraft - Stanford CA, US
James Hole - Burlingame CA, US

International Classification:

A61M 1/00
A61M 25/01
A61M 5/00
A61M 5/31
A61M 31/00
A61B 10/02
A61B 17/14
A61B 17/32

US Classification:

604 35, 604239, 604500, 600565, 600566, 600568, 606 86 R, 606167, 606170, 606180

Abstract:

Device and method for rapid extraction of body tissue from an enclosed body cavity. Hollow entry cannula with optional core element provides entry into body tissue space such as bone marrow. Aspiration cannula is inserted through cannula into body tissue and is manipulated to advance directionally through body cavity. Optional stylet within aspiration cannula aids in advancing aspiration cannula through body tissue and is removed to facilitate extraction of body tissue through the aspiration cannula. Inlet openings near distal tip of aspiration cannula allow tissue aspiration, with negative pressure source at proximal end of aspiration cannula providing controlled negative pressure. Aspiration cannula may be withdrawn and its path adjusted for multiple entries through the same entry point, following different paths through tissue space for subsequent aspiration of more tissue.

US Patent:

20030225364, Dec 4, 2003

Filed:

Jun 4, 2003

Appl. No.:

10/454846

Inventors:

Daniel Kraft - Stanford CA, US
James Hole - Burlingame CA, US

Assignee:

STANFORD, Office of Technology Licensing - Palo Alto CA

International Classification:

A61M001/00

US Classification:

604/035000, 604/095040

Abstract:

Device and method for rapid extraction of body tissue from an enclosed body cavity. Hollow entry cannula with optional core element provides entry into body tissue space such as bone marrow. Aspiration cannula is inserted through entry cannula into body tissue and is manipulated to advance directionally through body cavity. Optional stylet within aspiration cannula aids in advancing aspiration cannula through body tissue and is removed to facilitate extraction of body tissue through the aspiration cannula. Inlet openings near distal tip of aspiration cannula allow tissue aspiration, with negative pressure source at proximal end of aspiration cannula providing controlled negative pressure. Aspiration cannula may be withdrawn and its path adjusted for multiple entries through the same entry point, following different paths through tissue space for subsequent aspiration of more tissue.

US Patent:

20070276352, Nov 29, 2007

Filed:

May 17, 2007

Appl. No.:

11/750287

Inventors:

Michael Crocker - Half Moon Bay CA, US
Steve Trebotich - Newark CA, US
Daniel Kraft - Stanford CA, US

Assignee:

StemCor Systems, Inc. - Menlo Park CA

International Classification:

A61M 31/00
A61M 1/00

US Classification:

604500000, 604035000

Abstract:

Devices and methods for extraction of body tissue from an enclosed body cavity are disclosed. The devices can have one or more whisks extending from the distal end of flexible or rigid cannula. The devices can have aspiration and/or irrigation systems configured to provide aspiration pressure and/or irrigate with fluid at the distal end of the cannula. The cannula can be configured to rotate and/or oscillate. Methods for using the devices to disrupt the matrix of cancellous bone or bone marrow and extract in vivo cancellous bone or bone marrow from a subject are also disclosed.

US Patent:

20090030338, Jan 29, 2009

Filed:

Jul 25, 2007

Appl. No.:

11/828048

Inventors:

Michael D. Crocker - Half Moon Bay CA, US
Steve Trebotich - Newark CA, US
Tom Brockman - Hayward CA, US
Daniel Kraft - Stanford CA, US

Assignee:

StemCor Systems, Inc. - Menlo Park CA

International Classification:

A61B 10/02

US Classification:

600562

Abstract:

Devices and methods for guiding surgical tools are disclosed. The guided surgical tools can be used to extract body tissue from an enclosed body cavity. The guide can have multiple channels for the surgical tools to pass through the guide. The channels can converge and exit at a single exit port. The channels can have distinct entry ports. The guide can have a configuration to provide stable seating at or adjacent to the target site.

US Patent:

20090208918, Aug 20, 2009

Filed:

Feb 12, 2009

Appl. No.:

12/370541

Inventors:

Daniel Kraft - Stanford CA, US

International Classification:

A01N 1/02
C12N 5/00
C12N 5/08
C12Q 1/02

US Classification:

435 12, 435374, 435372, 4352841, 435 29

Abstract:

Devices and methods are provided for the ex vivo maintenance of bone marrow ‘niches’ or normal physiologic home of bone marrow (BM). Intact bone marrow is perfused with a medium that supports cell viability. Stem and progenitor cells may be maintained, expanded or differentiated within the system, screened for responses to various agents, or used to generate blood products.