Christiane E Wobus

US Patent:

7794928, Sep 14, 2010

Filed:

Feb 4, 2008

Appl. No.:

12/025327

Inventors:

Herbert W. Virgin - St. Louis MO, US
Christiane Wobus - Dexter MI, US
Stephanie Karst - Shreveport LA, US

Assignee:

Washington University - Saint Louis MO

International Classification:

C12Q 1/70
C12P 21/04
C12N 5/00
C12N 7/00
G01N 33/567

US Classification:

435 5, 435 721, 435 703, 4352351, 435239, 435325

Abstract:

A norovirus-permissive cell culture infected with a norovirus, and methods of culturing a norovirus, are disclosed. Norovirus-permissive cells include dendritic cell-lineage cells, and macrophage-lineage cells, such as dendritic cells, and macrophages having a deficiency in a cellular anti-viral pathway such as a STAT-1-dependent pathway, an interferon receptor-dependent pathway, or a PKR-dependent pathway. Also disclosed are methods of screening anti-viral compounds against norovirus-permissive cells infected with norovirus, and norovirus adapted to grow in fibroblasts as well as macrophages that are not deficient in a cellular anti-viral pathway. Methods of making a norovirus vaccine are also disclosed. A replicative form of norovirus as well as its use in the development of an anti-viral agent and a polypeptide expression system are also described. Further disclosed are methods of detecting norovirus in a sample.

US Patent:

20050255480, Nov 17, 2005

Filed:

May 5, 2004

Appl. No.:

10/839211

Inventors:

Herbert Virgin - St. Louis MO, US
Christiane Wobus - Kirkwood MO, US
Stephanie Karst - St. Louis MO, US

International Classification:

C12Q001/70
C12Q001/68
C12N007/00
C12N007/01
C12N015/00
C12N015/09
C12N015/63
C12N015/70
C12N015/74
C12N005/00
C12N005/02
A61K031/40
A01N043/36

US Classification:

435006000, 435320100, 435235100, 435325000

Abstract:

A norovirus-permissive cell culture infected with a norovirus, and methods of culturing a norovirus, are disclosed. Norovirus-permissive cells include dendritic cell-lineage cells, and macrophage-lineage cells, such as dendritic cells, and macrophages having a deficiency in a cellular anti-viral pathway such as a STAT-1-dependent pathway, an interferon receptor-dependent pathway, or a PKR-dependent pathway. Also disclosed are methods of screening anti-viral compounds against norovirus-permissive cells infected with norovirus, and norovirus adapted to grow in fibroblasts as well as macrophages that are not deficient in a cellular anti-viral pathway. Methods of making a norovirus vaccine are also disclosed.

US Patent:

20060003957, Jan 5, 2006

Filed:

May 5, 2005

Appl. No.:

11/122944

Inventors:

Herbert Virgin - Clayton MO, US
Christiane Wobus - Kirkwood MO, US
Stephanie Karst - Shreveport LA, US

International Classification:

A61K 48/00
C07H 21/02

US Classification:

514044000, 536023720

Abstract:

A norovirus-permissive cell culture infected with a norovirus, and methods of culturing a norovirus, are disclosed. Norovirus-permissive cells include dendritic cell-lineage cells, and macrophage-lineage cells, such as dendritic cells, and macrophages having a deficiency in a cellular anti-viral pathway such as a STAT-1-dependent pathway, an interferon receptor-dependent pathway, or a PKR-dependent pathway. Also disclosed are methods of screening anti-viral compounds against norovirus-permissive cells infected with norovirus, and norovirus adapted to grow in fibroblasts as well as macrophages that are not deficient in a cellular anti-viral pathway. Methods of making a norovirus vaccine are also disclosed. A replicative form of norovirus as well as its use in the development of an anti-viral agent and a polypeptide expression system are also described.

US Patent:

20120077806, Mar 29, 2012

Filed:

Sep 23, 2011

Appl. No.:

13/241802

Inventors:

Nicholas J. Donato - Ann Arbor MI, US
Christiane Wobus - Dexter MI, US
Hollis D. Showalter - Ann Arbor MI, US
Moshe Talpaz - Ann Arbor MI, US
Jeffrey W. Perry - Ypsilanti MI, US
Roderick J. Sorenson - Ann Arbor MI, US
Mary X. O'Riordan - Ann Arbor MI, US
Yafei Jin - Ann Arbor MI, US

Assignee:

THE REGENTS OF THE UNIVERSITY OF MICHIGAN - Ann Arbor MI

International Classification:

A61K 31/541
C12N 5/02
A61K 31/5377
A61K 31/53
A61K 31/50
C07D 413/12
A61K 31/496
A61K 31/505
A61K 31/454
A61K 31/4439
A61K 31/44
A61K 31/433
A61K 31/4245
A61K 31/426
A61K 31/42
A61K 31/4164
A61K 31/415
A61K 31/165
C07D 417/12
C07D 253/065
C07D 253/04
C07D 237/06
C07D 239/02
A61K 31/4965
C07D 401/12
C07D 213/57
C07D 285/06
C07D 285/12
C07D 271/10
C07D 277/30
C07D 261/06
C07D 233/90
C07D 231/10
C07C 255/32
A61P 25/28
A61P 31/04
A61P 31/10
A61P 31/12
A61P 33/00
A61P 35/00
C12N 9/99

US Classification:

5142278, 435184, 435375, 5142372, 514241, 514242, 514247, 5142521, 51425301, 514256, 514326, 514341, 514357, 514361, 514363, 514364, 514365, 514378, 514400, 514406, 514620, 544 60, 544131, 544182, 544215, 544224, 544335, 544336, 544360, 546210, 5462764, 546330, 548127, 548136, 548143, 548204, 548247, 5483361, 5483751, 558392

Abstract:

Disclosed herein are methods of inhibiting a deubiquitinase (DUB), methods of treating pathogenic infections (e.g., viral, bacterial, and/or parasitic), methods of inhibiting cell proliferation, methods of treating a neurodegenerative disease, methods of treating one or more symptoms of a neurodegenerative disease or a genetic disorder, and compounds.

US Patent:

20160237082, Aug 18, 2016

Filed:

Oct 10, 2014

Appl. No.:

15/027714

Inventors:

- Ann Arbor MI, US
Moshe Talpaz - Ann Arbor MI, US
Luke Peterson - Ann Arbor MI, US
Matthew Young - Ann Arbor MI, US
Hollis D. Showalter - Ann Arbor MI, US
Christiane Wobus - Dexter MI, US
Mary Xuan Dziem O'Riordan - Ann Arbor MI, US
Monika Ermann - Abingdon, Oxfordshire, GB

International Classification:

C07D 471/04
C07D 215/14
C07D 213/57

Abstract:

Disclosed herein are methods of inhibiting a deubiquitinase (DUB) by contact with a compound of formula (I)

US Patent:

20150079115, Mar 19, 2015

Filed:

Sep 16, 2014

Appl. No.:

14/487592

Inventors:

- Baltimore MD, US
Jeffrey S. Lin - Silver Spring MD, US
Kellogg Schwab - Bel Air MD, US
Timothy Julian - Baltimore MD, US
Christiane Wobus - Dexter MI, US
David Weitz - Bolton MA, US
David Heyman - Somerville MA, US

International Classification:

A61K 39/44
A23L 1/30
A61K 47/48

US Classification:

4241781, 435 5

Abstract:

Food products and/or pharmaceutical preparations including (i) viral neutralizing antibodies or antibody fragments anchored to a probiotic microorganism and (ii) a carrier medium for delivering the viral neutralizing antibodies or antibody fragments anchored to probiotic microorganisms to the gut of a mammal. Also provided are methods of making food products and/or pharmaceutical preparations, which can be used to treat existing viral infections or prevent the spread or transmission of viral infection.

US Patent:

20140357673, Dec 4, 2014

Filed:

Jul 31, 2014

Appl. No.:

14/448203

Inventors:

- Ann Arbor MI, US
Christiane Wobus - Dexter MI, US
Hollis D. Showalter - Ann Arbor MI, US
Moshe Talpaz - Ann Arbor MI, US
Jeffrey William Perry - Ypsilanti MI, US
Roderick Joseph Sorenson - Ann Arbor MI, US
Mary Xuan Dziem O'Riordan - Ann Arbor MI, US
Yafei Jin - Ann Arbor MI, US

International Classification:

C07D 495/04
C07D 213/61
C07D 233/64

US Classification:

514338, 5483361, 514400, 546330, 514357, 5462731

Abstract:

Disclosed herein are methods of inhibiting a deubiquitinase (DUB), methods of treating pathogenic infections (e.g., viral, bacterial, and/or parasitic), methods of inhibiting cell proliferation, methods of treating a neurodegenerative disease, methods of treating one or more symptoms of a neurodegenerative disease or a genetic disorder, and compounds.