Charles M Moehle

US Patent:

20020018774, Feb 14, 2002

Filed:

Dec 17, 1998

Appl. No.:

09/213678

Inventors:

SIMON GREEN - PLEASANTON CA, US
GARY DALLMANN - MENLO PARK CA, US
MAGDELEINE HUNG - HAYWARD CA, US
JULIE LANE - OAKLAND CA, US
CHARLES M. MOEHLE - CASTRO VALLEY CA, US

International Classification:

G01N033/53
C12N005/00
C12N015/70
C12P021/06
A61K039/395
C12N015/74
C12N015/63
C12N015/09
G01N033/569
C07H021/04
C12P021/04
C12N015/00
C12N005/02

US Classification:

424/130100, 536/023500, 435/320100, 435/325000, 435/071200, 435/069100, 435/007100, 435/975000

Abstract:

The present invention relates to enzymes involved in capping of fungal mRNAs, and molecules that inhibit such enzymes. In particular, the invention relates to the novel capping enzyme genes ABD1 and CET1 and their encoded protein products, as well as derivatives and analogs thereof. The invention also relates to methods of using of fungal capping enzymes to screen for fungal inhibitors.

US Patent:

58719237, Feb 16, 1999

Filed:

Feb 19, 1997

Appl. No.:

8/802626

Inventors:

Charles M. Moehle - Hayward CA

Assignee:

Ribogene, Inc. - Hayward CA

International Classification:

C12Q 168

US Classification:

435 6

Abstract:

Screening methods for identification of antimy-cotic agents active in mycotic cell translation, the agents identified thereby, and uses of these agents.

US Patent:

59981598, Dec 7, 1999

Filed:

Feb 10, 1998

Appl. No.:

9/021184

Inventors:

Julia C. Watson - San Jose CA
Charles M. Moehle - Castro Valley CA
Ritu Gina Bahador - Dublin CA
Victor James Hernandez - Williamsville NY

Assignee:

RiboGene, Inc. - Hayward CA

International Classification:

C12Q 102
C12Q 118

US Classification:

435 29

Abstract:

The present invention provides methods for identification of antibiotic agents which cause the accumulation of ppGpp in bacterial organisms involving a relA-independent pathway. The methods comprise screening assays in which test compounds are brought into contact with relA. sup. - test cells and observing the effect such compounds have on ppGpp levels in the test cells. The invention also provides genetically manipulated relA. sup. - test cells which contain a reporter gene the expression of which is sensitive to the level of ppGpp. The invention also encompasses agents identified by the screening assays, and uses of these agents in the treatment of infectious diseases.

US Patent:

56416270, Jun 24, 1997

Filed:

Oct 24, 1994

Appl. No.:

8/328258

Inventors:

Charles M. Moehle - Hayward CA

Assignee:

RiboGene, Inc. - Hayward CA

International Classification:

C12Q 168
C12N 116
C12N 119
C12N 1500

US Classification:

435 6

Abstract:

This application relates to screening methods for identification of antimycotic agents active in mycotic cell translation, the agents identified thereby, and uses of these agents.