Changping Shi

US Patent:

20110275161, Nov 10, 2011

Filed:

May 5, 2010

Appl. No.:

12/774695

Inventors:

SHOUFA HAN - San Bruno CA, US
Changping Shi - San Francisco CA, US

Assignee:

MCLAB - South San Francisco CA

International Classification:

G01N 21/76
C07D 491/22
C07D 491/107

US Classification:

436104, 548410, 546 15, 436172

Abstract:

The teachings provided herein are directed to compounds and methods for detecting nerve agents using rhodamine-derived detection compounds. A rhodamine-derived detection compound for nerve agents can include any rhodamine derivative that can bind to a nerve agent and produce a detectable signal for detection of the nerve agent. In some embodiments, the rhodamine-derived detection compound comprises rhodamine B-hydroxamate and the nerve agent can be detected in amounts as low as about 10 ppm.

US Patent:

20220267434, Aug 25, 2022

Filed:

May 10, 2022

Appl. No.:

17/741126

Inventors:

- South San Francisco CA, US
Changping Shi - South San Francisco CA, US
Dan Shen - South San Francisco CA, US

International Classification:

C07K 16/26
A61K 47/65
C12N 15/62
A61K 38/27
A61K 38/26
A61K 38/18
C07K 14/495
A61K 47/68
A61K 47/66
C12N 15/09
C07K 14/61

Abstract:

Chimeric Fc fusion polypeptides are provided, optionally including biologically active polypeptides for therapeutic use.

US Patent:

20190218285, Jul 18, 2019

Filed:

Jan 18, 2019

Appl. No.:

16/252030

Inventors:

- South San Francisco CA, US
Changping Shi - South San Francisco CA, US
Dan Shen - South San Francisco CA, US

International Classification:

C07K 16/26
A61K 47/66
A61K 47/65
C12N 15/62
A61K 38/27
A61K 38/26
A61K 38/18
C07K 14/495
A61K 47/68

Abstract:

Chimeric Fc fusion polypeptides are provided, optionally including biologically active polypeptides for therapeutic use.

US Patent:

20180087050, Mar 29, 2018

Filed:

May 26, 2016

Appl. No.:

15/577193

Inventors:

Jianbiao ZHENG - Fremont CA, US
Changping SHI - San Francisco CA, US

International Classification:

C12N 15/10
C12Q 1/68

Abstract:

The present invention provides compositions, methods, and kits for inserting a plurality of synthetic transposons each comprising a different nucleic acid sequence (i.e., molecular barcode) in a target nucleic acid of interest to allow extraction of contiguity information in the target nucleic acid. The molecular barcodes are also useful for reducing amplification or sequencing bias and errors, and for guiding accurate sequence assembly of the target nucleic acid from sequencing reads. The compositions, methods, and kits described herein have many applications, including haplotyping, genome assembly, sequencing of repetitive regions, detection of structural variations and copy number variations, chromosomal conformation analysis, and methylation analysis.

US Patent:

20160348152, Dec 1, 2016

Filed:

May 26, 2016

Appl. No.:

15/165543

Inventors:

- South San Francisco CA, US
Changping Shi - San Francisco CA, US
Dan Shen - San Bruno CA, US
Thang Nguyen - San Francisco CA, US

Assignee:

Molecular Cloning Laboratories (MCLAB) LLC - South San Francisco CA

International Classification:

C12Q 1/68

Abstract:

Compositions comprising activated topoisomerase adaptors (TOPO-adaptors) and methods of using the activated TOPO-adaptors are provided for preparing a library of target DNA duplexes derived from sample polynucleotides (e.g., DNA, RNA) for the streamlined preparation of a large number of samples. Such libraries may be used for Next Generation Sequencing (NGS).