Sek Chung Fung - Gaithersburg MD, US Matthew Moyle - Redmond WA, US Mason Lu - Houston TX, US Changning Yan - Houston TX, US Sanjaya Singh - Sandy Hook CT, US Dan Huang - Short Hills NJ, US
The present invention relates to anti-IL13 antibodies that bind specifically and with high affinity to both glycosylated and non-glycosylated human IL13, does not bind mouse IL13, and neutralize human IL13 activity at an approximate molar ratio of 1:2 (MAb:IL13). The invention also relates to the use of these antibodies in the treatment of IL13-mediated diseases, such as allergic disease, including asthma, allergic asthma, non-allergic (intrinsic) asthma, allergic rhinitis, atopic dermatitis, allergic conjunctivitis, eczema, urticaria, food allergies, chronic obstructive pulmonary disease, ulcerative colitis, RSV infection, uveitis, scleroderma, and osteoporosis.
Sek Chung Fung - Gaithersburg MD, US Matthew Moyle - Redmond WA, US Mason Lu - Houston TX, US Changning Yan - Houston TX, US Sanjaya Singh - Sandy Hook CT, US Dan Huang - Short Hills NY, US
Assignee:
Genentech, Inc. - San Francisco CA
International Classification:
A61K 39/395 C07K 16/24
US Classification:
4241331, 5303879, 5303873, 4241391
Abstract:
The present invention relates to anti-IL13 antibodies that bind specifically and with high affinity to both glycosylated and non-glycosylated human IL13, does not bind mouse IL13, and neutralize human IL13 activity at an approximate molar ratio of 1:2 (MAb:IL13). The invention also relates to the use of these antibodies in the treatment of IL13-mediated diseases, such as allergic disease, including asthma, allergic asthma, non-allergic (intrinsic) asthma, allergic rhinitis, atopic dermatitis, allergic conjunctivitis, eczema, urticaria, food allergies, chronic obstructive pulmonary disease, ulcerative colitis, RSV infection, uveitis, scleroderma, and osteoporosis.
Sek Chung Fung - Gaithersburg MD, US Matthew Moyle - Redmond WA, US Mason Lu - Houston MA, US Changning Yan - Houston TX, US Sanjaya Singh - Sandy Hook CT, US Dan Huang - Short Hills NJ, US
The present invention relates to anti-IL13 antibodies that bind specifically and with high affinity to both glycosylated and non-glycosylated human IL13, does not bind mouse IL13, and neutralize human IL13 activity at an approximate molar ratio of 1:2 (MAb:IL13). The invention also relates to the use of these antibodies in the treatment of IL13-mediated diseases, such as allergic disease, including asthma, allergic asthma, non-allergic (intrinsic) asthma, allergic rhinitis, atopic dermatitis, allergic conjunctivitis, eczema, urticaria, food allergies, chronic obstructive pulmonary disease, ulcerative colitis, RSV infection, uveitis, scleroderma, and osteoporosis.
Sek Chung Fung - Gaithersburg MD, US Matthew Moyle - Redmond WA, US Mason Lu - Houston TX, US Changning Yan - Houston TX, US Sanjaya Singh - Sandy Hook CT, US Dan Huang - Short Hills NJ, US
International Classification:
A61K 39/395 A61P 37/08 A61P 11/06
US Classification:
4241351, 4241451, 4241331, 4241361, 4241781
Abstract:
The present invention relates to anti-IL13 antibodies that bind specifically and with high affinity to both glycosylated and non-glycosylated human IL13, does not bind mouse IL13, and neutralize human IL13 activity at an approximate molar ratio of 1:2 (MAb:IL13). The invention also relates to the use of these antibodies in the treatment of IL13-mediated diseases, such as allergic disease, including asthma, allergic asthma, non-allergic (intrinsic) asthma, allergic rhinitis, atopic dermatitis, allergic conjunctivitis, eczema, urticaria, food allergies, chronic obstructive pulmonary disease, ulcerative colitis, RSV infection, uveitis, scleroderma, and osteoporosis.
Sek Chung Fung - Gaithersburg MD, US Matthew Moyle - Redmond WA, US Mason Lu - Houston TX, US Changning Yan - Houston TX, US Sanjaya Singh - Sandy Hook CT, US Dan Huang - Short Hills NJ, US
International Classification:
C07K 16/24 C07K 16/46
US Classification:
5303873, 5303892, 5303879, 53038823
Abstract:
The present invention relates to anti-IL13 antibodies that bind specifically and with high affinity to both glycosylated and non-glycosylated human IL13, does not bind mouse IL13, and neutralize human IL13 activity at an approximate molar ratio of 1:2 (MAb:IL13). The invention also relates to the use of these antibodies in the treatment of IL13-mediated diseases, such as allergic disease, including asthma, allergic asthma, non-allergic (intrinsic) asthma, allergic rhinitis, atopic dermatitis, allergic conjunctivitis, eczema, urticaria, food allergies, chronic obstructive pulmonary disease, ulcerative colitis, RSV infection, uveitis, scleroderma, and osteoporosis.
- South San Francisco CA, US Matthew MOYLE - Redmond WA, US Mason LU - Houston TX, US Changning YAN - Houston TX, US Sanjaya SINGH - Sandy Hook CT, US Dan HUANG - Short Hills NJ, US
Assignee:
Genentech, Inc. - South San Francisco CA
International Classification:
C07K 16/24
Abstract:
The present invention relates to anti-IL13 antibodies that bind specifically and with high affinity to both glycosylated and non-glycosylated human IL13, does not bind mouse IL13, and neutralize human IL13 activity at an approximate molar ratio of 1:2 (MAb:IL13). The invention also relates to the use of these antibodies in the treatment of IL13-mediated diseases, such as allergic disease, including asthma, allergic asthma, non-allergic (intrinsic) asthma, allergic rhinitis, atopic dermatitis, allergic conjunctivitis, eczema, urticaria, food allergies, chronic obstructive pulmonary disease, ulcerative colitis, RSV infection, uveitis, scleroderma, and osteoporosis.
- South San Francisco CA, US Matthew MOYLE - Redmond WA, US Mason LU - Houston TX, US Changning YAN - Houston TX, US Sanjaya SINGH - Sandy Hook CT, US Dan Huang - Short Hills NJ, US
International Classification:
C07K 16/24 A61K 39/00
Abstract:
The present invention relates to anti-IL13 antibodies that bind specifically and with high affinity to both glycosylated and non-glycosylated human IL13, does not bind mouse IL13, and neutralize human IL13 activity at an approximate molar ratio of 1:2 (MAb:IL13). The invention also relates to the use of these antibodies in the treatment of IL13-mediated diseases, such as allergic disease, including asthma, allergic asthma, non-allergic (intrinsic) asthma, allergic rhinitis, atopic dermatitis, allergic conjunctivitis, eczema, urticaria, food allergies, chronic obstructive pulmonary disease, ulcerative colitis, RSV infection, uveitis, scleroderma, and osteoporosis.
- San Fransisco CA, US Matthew Moyle - Redmond WA, US Mason Lu - Houston TX, US Changning Yan - Houston TX, US Sanjaya Singh - Sandy Hook CT, US Dan Huang - Short Hills NJ, US
Assignee:
Genentech, Inc. - San Fransisco CA
International Classification:
C07K 16/24
US Classification:
4241351, 4241331, 4241361, 4241451, 4241781
Abstract:
The present invention relates to anti-IL13 antibodies that bind specifically and with high affinity to both glycosylated and non-glycosylated human IL13, does not bind mouse IL13, and neutralize human IL13 activity at an approximate molar ratio of 1:2 (MAb:IL13). The invention also relates to the use of these antibodies in the treatment of IL13-mediated diseases, such as allergic disease, including asthma, allergic asthma, non-allergic (intrinsic) asthma, allergic rhinitis, atopic dermatitis, allergic conjunctivitis, eczema, urticaria, food allergies, chronic obstructive pulmonary disease, ulcerative colitis, RSV infection, uveitis, scleroderma, and osteoporosis.
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