Chad A Mirkin

US Patent:

6361944, Mar 26, 2002

Filed:

Jun 25, 1999

Appl. No.:

09/344667

Inventors:

Chad A. Mirkin - Wilmette IL
Robert L. Letsinger - Wilmette IL
Robert C. Mucic - Glendale CA
James J. Storhoff - Evanston IL
Robert Elghanian - Chicago IL

Assignee:

Nanosphere, Inc. - Northbrook IL

International Classification:

C12Q 168

US Classification:

435 6, 435 911, 435 912, 536 221, 536 231, 536 243, 536 2433

Abstract:

The invention provides methods of detecting a nucleic acid. The methods comprise contacting the nucleic acid with one or more types of particles having oligonucleotides attached thereto. In one embodiment of the method, the oligonucleotides are attached to nanoparticles and have sequences complementary to portions of the sequence of the nucleic acid. A detectable change (preferably a color change) is brought about as a result of the hybridization of the oligonucleotides on the nanoparticles to the nucleic acid. The invention also provides compositions and kits comprising particles. The invention further provides nanomaterials and nanostructures comprising nanoparticles and methods of nanofabrication utilizing the nanoparticles. Finally, the invention provides a method of separating a selected nucleic acid from other nucleic acids.

US Patent:

6417340, Jul 9, 2002

Filed:

Oct 20, 2000

Appl. No.:

09/693352

Inventors:

Chad A. Mirkin - Wilmette IL
Robert L. Letsinger - Wilmette IL
Robert C. Mucic - Glendale CA
James J. Storhoff - Evanston IL
Robert Elghanian - Chicago IL

Assignee:

Nanosphere, Inc. - Northbrook IL

International Classification:

C07H 1900

US Classification:

536 231, 536 221, 536 243, 536 2433, 435 6, 435 71, 435 72

Abstract:

The invention provides methods of detecting a nucleic acid. The methods comprise contacting the nucleic acid with one or more types of particles having oligonucleotides attached thereto. In one embodiment of the method, the oligonucleotides are attached to nanoparticles and have sequences complementary to portions of the sequence of the nucleic acid. A detectable change (preferably a color change) is brought about as a result of the hybridization of the oligonucleotides on the nanoparticles to the nucleic acid. The invention also provides compositions and kits comprising particles. The invention further provides nanomaterials and nanostructures comprising nanoparticles and methods of nanofabrication utilizing the nanoparticles. Finally, the invention provides a method of separating a selected nucleic acid from other nucleic acids.

US Patent:

6495324, Dec 17, 2002

Filed:

Oct 20, 2000

Appl. No.:

09/693005

Inventors:

Chad A. Mirkin - Wilmette IL
Robert L. Letsinger - Wilmette IL
Robert C. Mucic - Glendale CA
James J. Storhoff - Evanston IL
Robert Elghanian - Chicago IL

Assignee:

Nanosphere, Inc. - Northbrook IL

International Classification:

C12Q 168

US Classification:

435 6, 536 221, 536 231, 536 243, 536 2433

Abstract:

The invention provides methods of detecting a nucleic acid. The methods comprise contacting the nucleic acid with one or more types of particles having oligonucleotides attached thereto. In one embodiment of the method, the oligonucleotides are attached to nanoparticles and have sequences complementary to portions of the sequence of the nucleic acid. A detectable change (preferably a color change) is brought about as a result of the hybridization of the oligonucleotides on the nanoparticles to the nucleic acid. The invention also provides compositions and kits comprising particles. The invention further provides nanomaterials and nanostructures comprising nanoparticles and methods of nanofabrication utilizing the nanoparticles. Finally, the invention provides a method of separating a selected nucleic acid from other nucleic acids.

US Patent:

6506564, Jan 14, 2003

Filed:

Jun 26, 2000

Appl. No.:

09/603830

Inventors:

Chad A. Mirkin - Wilmette IL
Robert L. Letsinger - Wilmette IL
Robert C. Mucic - Glendale CA
James J. Storhoff - Evanston IL
Robert Elghanian - Chicago IL
Thomas A. Taton - Chicago IL

Assignee:

Nanosphere, Inc. - Northbrook IL

International Classification:

C12Q 168

US Classification:

435 6, 536 221, 536 231, 536 243, 536 2433, 536 253

Abstract:

The invention provides methods of detecting a nucleic acid. The methods comprise contacting the nucleic acid with one or more types of particles having oligonucleotides attached thereto. In one embodiment of the method, the oligonucleotides are attached to nanoparticles and have sequences complementary to portions of the sequence of the nucleic acid. A detectable change (preferably a color change) is brought about as a result of the hybridization of the oligonucleotides on the nanoparticles to the nucleic acid. The invention also provides compositions and kits comprising particles. The invention further provides methods of synthesizing unique nanoparticle-oligonucleotide conjugates, the conjugates produced by the methods, and methods of using the conjugates. In addition, the invention provides nanomaterials and nanostructures comprising nanoparticles and methods of nanofabrication utilizing nanoparticles. Finally, the invention provides a method of separating a selected nucleic acid from other nucleic acids.

US Patent:

6582921, Jun 24, 2003

Filed:

Sep 20, 2001

Appl. No.:

09/961949

Inventors:

Chad A. Mirkin - Wilmette IL
Robert L. Letsinger - Wilmette IL
Robert C. Mucic - Glendale CA
James J. Storhoff - Evanston IL
Robert Elghanian - Chicago IL
Thomas A. Taton - Chicago IL

Assignee:

Nanosphere, Inc. - Northbrook IL

International Classification:

C12Q 168

US Classification:

435 6, 536 221, 536 231, 536 266

Abstract:

The invention provides methods of detecting a nucleic acid. The methods comprise contacting the nucleic acid with one or more types of particles having oligonucleotides attached thereto. In one embodiment of the method, the oligonucleotides are attached to nanoparticles and have sequences complementary to portions of the sequence of the nucleic acid. A detectable change (preferably a color change) is brought about as a result of the hybridization of the oligonucleotides on the nanoparticles to the nucleic acid. The invention also provides compositions and kits comprising particles. The invention further provides methods of synthesizing unique nanoparticle-oligonucleotide conjugates, the conjugates produced by the methods, and methods of using the conjugates. In addition, the invention provides nanomaterials and nanostructures comprising nanoparticles and methods of nanofabrication utilizing nanoparticles. Finally, the invention provides a method of separating a selected nucleic acid from other nucleic acids.

US Patent:

6610491, Aug 26, 2003

Filed:

Sep 28, 2001

Appl. No.:

09/966491

Inventors:

Chad A. Mirkin - Wilmette IL
Robert L. Letsinger - Wilmette IL
Robert C. Mucic - Glendale CA
James J. Storhoff - Evanston IL
Robert Elghanian - Chicago IL
Thomas A. Taton - Chicago IL

Assignee:

Nanosphere, Inc. - Northbrook IL

International Classification:

C12Q 166

US Classification:

435 6, 536 231, 536 253, 536 266

Abstract:

The invention provides methods of detecting a nucleic acid. The methods comprise contacting the nucleic acid with one or more types of particles having oligonucleotides attached thereto. In one embodiment of the method, the oligonucleotides are attached to nanoparticles and have sequences complementary to portions of the sequence of the nucleic acid. A detectable change (preferably a color change) is brought about as a result of the hybridization of the oligonucleotides on the nanoparticles to the nucleic acid. The invention also provides compositions and kits comprising particles. The invention further provides methods of synthesizing unique nanoparticle-oligonucleotide conjugates, the conjugates produced by the methods, and methods of using the conjugates. In addition, the invention provides nanomaterials and nanostructures comprising nanoparticles and methods of nanofabrication utilizing nanoparticles. Finally, the invention provides a method of separating a selected nucleic acid from other nucleic acids.

US Patent:

6635311, Oct 21, 2003

Filed:

Jan 5, 2000

Appl. No.:

09/477997

Inventors:

Chad A. Mirkin - Wilmette IL
Richard Piner - Des Plaines IL
Seunghun Hong - Chicago IL

Assignee:

Northwestern University - Evanston IL

International Classification:

B05D 500

US Classification:

427256, 427287

Abstract:

A method of direct-write nanolithography comprising: providing a solid substrate comprising a surface; providing a nanoscopic tip coated with patterning compound; and contacting the coated tip with the substrate, so that the patterning compound is delivered to the substrate so as to produce a desired pattern in submicrometer dimensions. Nanolithographic resolution can be affected by substrate grain size, diffusion rate of the patterning compound, tip-substrate contact time, the rate of transport of the patterning compound from the tip to the substrate, and tip sharpness. The method is a useful tool for fabrication of nanoscale structures.

US Patent:

6645721, Nov 11, 2003

Filed:

Sep 20, 2001

Appl. No.:

09/957313

Inventors:

Chad A. Mirkin - Wilmette IL
Robert L. Letsinger - Wilmette IL
Robert C. Mucic - Glendale CA
James J. Storhoff - Evanston IL
Robert Elghanian - Skokie IL
Thomas A. Taton - Little Canada MN

Assignee:

Nanosphere, Inc. - Northbrook IL

International Classification:

C12Q 168

US Classification:

435 6, 536 221, 536 231, 536 243, 536 266

Abstract:

The invention provides methods of detecting a nucleic acid. The methods comprise contacting the nucleic acid with one or more types of particles having oligonucleotides attached thereto. In one embodiment of the method, the oligonucleotides are attached to nanoparticles and have sequences complementary to portions of the sequence of the nucleic acid. A detectable change (preferably a color change) is brought about as a result of the hybridization of the oligonucleotides on the nanoparticles to the nucleic acid. The invention also provides compositions and kits comprising particles. The invention further provides methods of synthesizing unique nanoparticle-oligonucleotide conjugates, the conjugates produced by the methods, and methods of using the conjugates. In addition, the invention provides nanomaterials and nanostructures comprising nanoparticles and methods of nanofabrication utilizing nanoparticles. Finally, the invention provides a method of separating a selected nucleic acid from other nucleic acids.

Author:

Chad A. Mirkin

ISBN #:

3527306587

Author:

Chad A. Mirkin

ISBN #:

3527316736

Author:

Chad A. Mirkin

ISBN #:

3527610383