Edward M. Acton - Menlo Park CA Carol W. Mosher - Stanford CA
Assignee:
SRI International - Menlo Park CA
International Classification:
A61K 3170 C07H 1524
US Classification:
536 17A
Abstract:
Described are 3'-deamino-3'-(4-methoxy-1-piperidinyl) derivatives of daunorubicin and doxorubicin having the formula ##STR1## wherein R is COCH. sub. 3 or --CHOHCH. sub. 3 in the case of daunorubicin derivatives, or is COCH. sub. 2 OH or --CHOH--CH. sub. 2 OH in the case of doxorubicin derivatives together with their pharmaceutically acceptable acid salts. The compounds have utility as antitumor agents.
Analogues Of Morpholinyl Daunorubicin And Morpholinyl Doxorubicin
Carol W. Mosher - Stanford CA George L. Tong - Cupertino CA Edward M. Acton - Menlo Park CA
Assignee:
SRI International - Menlo Park CA
International Classification:
C07H 1524
US Classification:
536 64
Abstract:
A group of new daunorubicin and doxorubicin derivatives is disclosed. These materials have the formula ##STR1## wherein R is CO--CH. sub. 3 or CHOH--CH. sub. 3 in the case of daunorubicin derivatives or CO--CH. sub. 2 OH or CHOH--CH. sub. 2 OH in the case of doxorubicin derivatives; X is O or NH; and A is either a cyano group (CN) or a hydrogen, subject to the limitation that when X is O, A must be a cyano group. When A is hydrogen, these compounds can exist as acid addition salts, as well. Derivatives of these compounds are disclosed as well.
3-Deamino-3-(4-Morpholinyl) Derivatives Of Daunorubicin And Doxorubicin
Edward M. Acton - Menlo Park CA Carol W. Mosher - Stanford CA
Assignee:
SRI International - Menlo Park CA
International Classification:
C07H 1524
US Classification:
536 17A
Abstract:
Described are 3'-deamino-3'-(4-morpholinyl) derivatives of daunorubicin and doxorubicin having the formula ##STR1## wherein R is COCH. sub. 3 or --CHOHCH. sub. 3 in the case of daunorubicin derivatives, or is --COCH. sub. 2 OH or --CHOHCH. sub. 2 OH in the case of doxorubicin derivatives together with their pharmaceutically acceptable acid addition salts. The compounds have utility as antitumor agents.
Analogues Of Morpholinyl Daunorubicin And Morpholinyl Doxorubicin
Carol W. Mosher - Stanford CA George L. Tong - Cupertino CA Edward M. Acton - Menlo Park CA
Assignee:
SRI International - Menlo Park CA
International Classification:
C07H 1524
US Classification:
536 64
Abstract:
A group of new daunorubicin and doxorubicin derivatives is disclosed. Included in this group are 3'-deamino-3'(3"-cyano-4"-morpholinyl doxorubicin; 3'-deamino-3'-(3"-cyano-4"-morpholinyl)-13-dihydoxorubicin; (3'-deamino-3'-(3"-cyano-4"-morpholinyl) daunorubicin; 3'-deamino-3'-(3"-cyano-4"-morpholinyl)-3-dihydrodaunorubicin; and 3'-deamino-3'-(4"-morpholinyl-5-iminodoxorubicin and derivatives thereof which have excellent activity as antitumor agents.