Caretha L Creasy

US Patent:

6355465, Mar 12, 2002

Filed:

Sep 11, 2000

Appl. No.:

09/659166

Inventors:

Caretha Lee Creasy - Erdenheim PA
Tania Tamson Testa - London, GB

Assignee:

SmithKline Beecham plc - Brentford

International Classification:

C12N 912

US Classification:

435194, 435 71, 4352523, 4353201, 536 232

Abstract:

Rattus YAK1 polypeptides and polynucleotides and method for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for screening for compounds which either agonize or antagonize rattus YAK1. Such compounds are expected to be useful in treatment of human diseases, including, but not limited to osteoarthritis, osteoporosis, rheumatoid arthritis.

US Patent:

20020064852, May 30, 2002

Filed:

May 14, 2001

Appl. No.:

09/855154

Inventors:

Caretha Creasy - Erdenheim PA, US
Brian Burns - King of Prussia PA, US

Assignee:

SmithKline Beecham Corporation/SmithKline Beecham plc.

International Classification:

C12N009/12
C07H021/04
C12P021/02
C12N005/06

US Classification:

435/194000, 435/069100, 435/325000, 536/023200

Abstract:

Mus Musculus mDYRK2 polypeptides and polynucleotides and method for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for screening for compounds that either agonize or antagonize Mus Musculus mDYRK2. Such compounds are expected to be useful in treatment of human diseases, including, but not limited to: bone loss including osteoporosis; inflammatory diseases such as Adult Respiratory Disease Syndrome (ARDS), Rheumatoid arthritis, Osteoarthritis, Inflammatory Bowel Disease (IBD), psoriasis, dermatitis, asthma, allergies; infections such as bacterial, fungal, protozoan and viral infections, particularly infections caused by HIV-1 or HIV-2; HIV-associated cachexia and other immunodeficiency disorders; septic shock; pain; injury; infertility; cancers; anorexia; bulimia; Parkinson's disease; cardiovascular disease including restenosis, atherosclerosis, acute heart failure, myocardial infarction; hypotension; hypertension; urinary retention; angina pectoris; ulcers; benign prostatic hypertrophy; and psychotic and neurological disorders, including anxiety, schizophrenia, manic depression, delirium, dementia, severe mental retardation and dyskinesias, such as Huntington's disease or Gilles dela Tourett's syndrome .

US Patent:

20030077679, Apr 24, 2003

Filed:

Sep 24, 2002

Appl. No.:

10/253349

Inventors:

Roland Annan - King of Prussia PA, US
Brian Burns - King of Prussia PA, US
Caretha Creasy - King of Prussia PA, US
Kathleen Herold - King of Prussia PA, US

International Classification:

G01N033/53
G01N033/537
G01N033/543
C12Q001/42

US Classification:

435/007920, 435/021000

Abstract:

Methods of finding agonists and antagonists to DYRK3 or DYRK2 are provided.

US Patent:

20030176375, Sep 18, 2003

Filed:

May 14, 2001

Appl. No.:

09/855145

Inventors:

Kenneth Lord - Collegeville PA, US
Susan Dillon - Chester Springs PA, US
Caretha Creasy - Erdenheim PA, US

International Classification:

A61K048/00
C07H021/04
C12P021/02
C12N005/06

US Classification:

514/044000, 435/325000, 435/320100, 435/069100, 536/023200

Abstract:

hYAK3-2 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing hYAK3-2 polypeptides and polynucleotides in the design of protocols for the treatment of bone loss including osteoporosis; inflammatory diseases such as Adult Respiratory Disease Syndrome (ARDS), Rheumatoid arthritis, Osteoarthritis, Inflammatory Bowel Disease (IBD), psoriasis, dermatitis, asthma, allergies; infections such as bacterial, fungal, protozoan and viral infections, particularly infections caused by HIV-1 or HIV-2; HIV-associated cachexia and other immunodeficiency disorders; septic shock; pain; injury; cancers including testicular cancer; anorexia; bulimia; neutropenia; cytopenia; anemias, including anemias due to renal insufficiency or to chronic disease, such as autoimmunity or cancer, and drug-induced anemias; polycythemia; myelosuppression; Parkinson's disease; cardiovascular disease including restenosis, atherosclerosis, acute heart failure, myocardial infarction; hypotension; hypertension; urinary retention; angina pectoris; ulcers; benign prostatic hypertrophy; and psychotic and neurological disorders, including anxiety, schizophrenia, manic depression, delirium, dementia, severe mental retardation and dyskinesias, such as Huntington's disease or Gilles dela Tourett's syndrome., among others, and diagnostic assays for such conditions.

US Patent:

59654201, Oct 12, 1999

Filed:

Apr 7, 1997

Appl. No.:

8/835170

Inventors:

Caretha L. Creasy - Norristown PA
Wei Xie - Hengyang, CN

Assignee:

SmithKline Beecham Corporation - Philadelphia PA

International Classification:

C12N 912
C07H 2104

US Classification:

435194

Abstract:

hYAK3 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing hYAK3 polypeptides and polynucleotides in the design of protocols for the treatment of bone loss including osteoporosis; inflammatory diseases such as Adult Respiratory Disease Syndrome (ARDS), Rheumatoid arthritis, Osteoarthritis, Inflammatory Bowel Disease (IBD), psoriasis, dermatitis, asthma, allergies; infections such as bacterial, fungal protozoan and viral infections, particularly infections caused by HIV-1 or HIV-2; HIV-associated cachexia and other immunodeficiency disorders; septic shock; pain; injury; cancers including testicular cancer; anorexia; bulimia; Parkinson's disease; cardiovascular disease including restenosis, atherosclerosis, acute heart failure, myocardial infarction; hypotension; hypertension; urinary retention; angina pectoris; ulcers; benign prostatic hypertrophy; and psychotic and neurological disorders, including anxiety, schizophrenia, manic depression, delirium, dementia, severe mental retardation and dyskinesias, such as Huntington's disease or Gilles dela Tourett's syndrome. , among others, and diagnostic assays for such conditions.

US Patent:

63233185, Nov 27, 2001

Filed:

Aug 10, 1999

Appl. No.:

9/371674

Inventors:

Kenneth A. Lord - Collegeville PA
Susan B. Dillon - Chester Springs PA
Caretha Creasy - Erdenheim PA

Assignee:

SmithKline Beecham Corporation - Philadelphia PA

International Classification:

C07K 100
C07H 2104
C12P 2106
C12N 900
C12N 500

US Classification:

530350

Abstract:

hYAK3-2 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing hYAK3-2 polypeptides and polynucleotides in the design of protocols for the treatment of bone loss including osteoporosis; inflammatory diseases such as Adult Respiratory Disease Syndrome (ARDS), Rheumatoid arthritis, Osteoarthritis, Inflammatory Bowel Disease (IBD), psoriasis, dermatitis, asthma, allergies; infections such as bacterial, fungal, protozoan and viral infections, particularly infections caused by HIV-1 or HIV-2; HIV-associated cachexia and other immunodeficiency disorders; septic shock; pain; injury; cancers including testicular cancer; anorexia; bulimia; neutropenia; cytopenia; anemias, including anemias due to renal insufficiency or to chronic disease, such as autoimmunity or cancer, and drug-induced anemias; polycythemia; myelosuppression; Parkinson's disease; cardiovascular disease including restenosis, atherosclerosis, acute heart failure, myocardial infarction; hypotension; hypertension; urinary retention; angina pectoris; ulcers; benign prostatic hypertrophy; and psychotic and neurological disorders, including anxiety, schizophrenia, manic depression, delirium, dementia, severe mental retardation and dyskinesias, such as Huntington's disease or Gilles dela Tourett's syndrome, among others, and diagnostic assays for such conditions.

US Patent:

61657662, Dec 26, 2000

Filed:

Jul 22, 1999

Appl. No.:

9/359257

Inventors:

Caretha L. Creasy - Norristown PA
Wei Xie - Hunan, CN

Assignee:

SmithKline Beecham Corporation - Philadelphia PA

International Classification:

C12N 912

US Classification:

435194

Abstract:

hYAK3 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing hYAK3 polypeptides and polynucleotides in the design of protocols for the treatment of bone loss including osteoporosis; inflammatory diseases such as Adult Respiratory Disease Syndrome (ARDS), Rheumatoid arthritis, Osteoarthritis, Inflammatory Bowel Disease (IBD), psoriasis, dermatitis, asthma, allergies; infections such as bacterial, fungal, protozoan and viral infections, particularly infections caused by HIV-1 or HIV-2; HIV-associated cachexia and other immunodeficiency disorders; septic shock; pain; injury; cancers including testicular cancer; anorexia; bulimia; Parkinson's disease; cardiovascular disease including restenosis, atherosclerosis, acute heart failure, myocardial infarction; hypotension; hypertension; urinary retention; angina pectoris; ulcers; benign prostatic hypertrophy; and psychotic and neurological disorders, including anxiety, schizophrenia, manic depression, delirium, dementia, severe mental retardation and dyskinesias, such as Huntington's disease or Gilles dela Tourett's syndrome. , among others, and diagnostic assays for such conditions.

US Patent:

59726067, Oct 26, 1999

Filed:

Feb 19, 1997

Appl. No.:

8/802466

Inventors:

Caretha L. Creasy - Norristown PA
George P. Livi - Havertown PA
Damien J. Dunnington - King of Prussia PA
Usman Shabon - Swarthmore PA

Assignee:

SmithKline Beecham Corporation - Philadelphia PA

International Classification:

C12Q 168
C12D 2106
C07H 2104
C12N 500

US Classification:

435 6

Abstract:

hYAK1 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing hYAK1 polypeptides and polynucleotides in the design of protocols for the treatment of bone loss including osteoporosis; inflammatory diseases such as Adult Respiratory Disease Syndromne (ARDS), Rheumatoid arthritis, Osteoarthritis, Inflammatory Bowel Disease (IBD), psoriasis, dermatitis, asthma, allergies; infections such as bacterial, fungal, protozoan and viral infections, particularly infections caused by HIV-1 or HIV-2; HIV-associated cachexia and other immunodeficiency disorders; septic shock; pain; injury; cancers; anorexia; bulimia; Parkinson's disease; cardiovascular disease including restenosis, atherosclerosis, acute heart failure, myocardial infarction; hypotension; hypertension; urinary retention; angina pectoris; ulcers; benign prostatic hypertrophy; and psychotic and neurological disorders, including anxiety, schizophrenia, manic depression, delirium, dementia, severe mental retardation and dyskinesias, such as Huntington's disease or Gilles dela Tourett's syndrome, among others, and diagnostic assays for such conditions.