Bryan T Mott

age ~43

from Vestavia Hills, AL

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Also known as:

Bryan Thomas Mott
Bryan Thomas Matt

Connected to:

Bryan Mott Phones & Addresses

Vestavia Hills, AL
Clemmons, NC
College Park, MD
Baltimore, MD
Alexandria, VA
Centreville, VA
Fairfax, VA
Ashburn, VA
Philadelphia, PA
1227 Dellwood Ave, Baltimore, MD 21211

Work

Position:

Craftsman/Blue Collar

Resumes

Chief Executive Officer And Consultant

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Location:

2225 Myrtlewood Dr, Vestavia Hills, AL 35216

Industry:

Research

Work:

Uab School of Medicine
Medical Doctor Student
Mott Consulting Ll
Chief Executive Officer and Consultant
National Center For Advancing Translational Sciences (Ncats) Jul 2013 - Jun 2017
Research Scientist
Johns Hopkins University Advanced Academic Programs May 2014 - Dec 2016
Adjunct Faculty
Johns Hopkins University Jul 2009 - Aug 2013
Graduate Student

Education:

University of Alabama at Birmingham 2017 - 2021
Doctor of Medicine, Doctorates, Medicine The Johns Hopkins University 2009 - 2013
Doctorates, Doctor of Philosophy, Chemistry George Mason University 1999 - 2005
Master of Science, Masters, Bachelors, Bachelor of Science, Chemistry

Skills:

Organic Chemistry
Hplc
Drug Design
Nmr
Chemistry
Science
Biochemistry
Organic Synthesis
Molecular Biology
Infectious Diseases
Mass Spectrometry
Drug Discovery
Cancer
Life Sciences
Laboratory
Clinical Development
Western Blotting
Medicinal Chemistry
Lc Ms
Chromatography
Lifesciences
Spectroscopy

Bryan Mott

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Us Patents

Trioxane Monomers And Dimers
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US Patent:

20120108545, May 3, 2012
Filed:

May 19, 2010
Appl. No.:

13/321343
Inventors:

Gary H. Posner - Baltimore MD, US
Lauren E. Woodard - Baltimore MD, US
David R. Levine - Baltimore MD, US
Deuk Kyu Moon - Baltimore MD, US
Bryan T. Mott - Baltimore MD, US
Assignee:

THE JOHNS HOPKINS UNIVERSITY - Baltimore MD
International Classification:

A61K 31/4433
C07D 493/18
A61K 31/357
A61K 31/695
A61P 31/00
A61P 33/00
A61P 33/06
A61K 31/4706
A61K 31/4709
A61P 25/18
A61K 31/5415
A61K 31/451
A61K 31/496
A61K 31/5513
A61K 31/519
A61K 31/554
A61P 35/00
A61P 35/02
C07D 405/14
US Classification:

514 63, 5462824, 514338, 549348, 514450, 514313, 514305, 514314, 5142262, 514327, 5142258, 51425213, 5142255, 514220, 51425941, 51421113, 51425404, 51425307
Abstract:

Monomeric and dimeric trioxane fluoroaryl amides, 5-carbon-linked, C-10 non-acetal trioxane dimer esters; trioxane silylamides; and trioxane dimer orthoesters and methods of their use for treating subjects infected with malaria or other parasitic infectious diseases including, but not limited to, toxoplasmic infection; subjects afflicted with psychiatric conditions associated with toxoplasmic infection; and subjects afflicted with cancer.

Small Molecule Inhibitors Of Lactate Dehydrogenase And Methods Of Use Thereof
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US Patent:

20220220078, Jul 14, 2022
Filed:

Jan 10, 2022
Appl. No.:

17/572359
Inventors:

- Bethesda MD, US
- Nashville TN, US
- Birmingham AL, US
- Philadelphia PA, US
Plamen CHRISTOV - Nashville TN, US
Chi V. DANG - Penn Valley PA, US
Victor DARLEY-USMAR - Birmingham AL, US
Xin HU - Frederick MD, US
Ajit JADHAV - Chantilly VA, US
Somnath JANA - Nashville TN, US
Kwangho KIM - Nashville TN, US
Jennifer L. KOUZNETSOVA - Silver Spring MD, US
William J. MOORE - Hagerstown MD, US
Bryan T. MOTT - College Park MD, US
Leonard M. NECKERS - Bethesda MD, US
Anton SIMEONOV - Bethesda MD, US
Gary Allen SULIKOWSKI - Nashville TN, US
Daniel Jason URBAN - Rockville MD, US
Shyh Ming YANG - Doylestown PA, US
International Classification:

C07D 231/20
C07D 403/04
C07D 417/04
C07D 417/14
A61K 31/415
A61K 31/4155
A61K 31/4178
A61K 31/422
A61K 31/427
A61K 31/437
A61K 31/4439
A61K 31/454
A61K 31/496
A61K 31/501
A61K 31/506
A61K 31/519
A61K 31/5355
A61K 45/06
C07D 231/38
C07D 401/04
C07D 403/06
C07D 409/04
C07D 413/04
C07D 471/04
C07D 495/04
C07D 495/14
Abstract:

Provided is a compound of formula (I)in which Ar, R, U, V, W, X, and p are as described herein. Also provided are methods of using a compound of formula (I), including a method of treating cancer, a method of treating a patient with cancer cells resistant to an anti-cancer agent, and a method of inhibiting lactate dehydrogenase A (LDHA) and/or lactate dehydrogenase B (LDHB) activity in a cell.

Small Molecule Inhibitors Of Lactate Dehydrogenase And Methods Of Use Thereof
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US Patent:

20210323928, Oct 21, 2021
Filed:

Jan 28, 2021
Appl. No.:

17/160868
Inventors:

- Bethesda MD, US
- Nashville TN, US
- Birmingham AL, US
- Philadelphia PA, US
Plamen CHRISTOV - Nashville TN, US
Chi V. DANG - Penn Valley PA, US
Victor DARLEY-USMAR - Birmingham AL, US
Xin HU - Frederick MD, US
Ajit JADHAV - Chantilly VA, US
Somnath JANA - Nashville TN, US
Kwangho KIM - Nashville TN, US
Jennifer L. KOUZNETSOVA - Silver Spring MD, US
William J. MOORE - Hagerstown MD, US
Bryan T. MOTT - College Park MD, US
Leonard M. NECKERS - Bethesda MD, US
Anton SIMEONOV - Bethesda MD, US
Gary Allen SULIKOWSKI - Nashville TN, US
Daniel Jason URBAN - Rockville MD, US
Shyh Ming YANG - Doylestown PA, US
International Classification:

C07D 231/20
C07D 403/04
C07D 417/04
C07D 417/14
A61K 31/415
A61K 31/4155
A61K 31/4178
A61K 31/422
A61K 31/427
A61K 31/437
A61K 31/4439
A61K 31/454
A61K 31/496
A61K 31/501
A61K 31/506
A61K 31/519
A61K 31/5355
A61K 45/06
C07D 231/38
C07D 401/04
C07D 403/06
C07D 409/04
C07D 413/04
C07D 471/04
C07D 495/04
C07D 495/14
Abstract:

Provided is a compound of formula (I)[Formula (I) should be inserted here], in which Ar, R, U, V, W, X, and p are as described herein. Also provided are methods of using a compound of formula (I), including a method of treating cancer, a method of treating a patient with cancer cells resistant to an anti-cancer agent, and a method of inhibiting lactate dehydrogenase A (LDHA) and/or lactate dehydrogenase B (LDHB) activity in a cell.

Small Molecule Inhibitors Of Lactate Dehydrogenase And Methods Of Use Thereof
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US Patent:

20200002285, Jan 2, 2020
Filed:

Jun 28, 2019
Appl. No.:

16/455848
Inventors:

- Bethesda MD, US
- Nashville TN, US
- Birmingham AL, US
- Philadelphia PA, US
Plamen Christov - Nashville TN, US
Chi V. Dang - Penn Valley PA, US
Victor Darley-Usmar - Birmingham AL, US
Xin Hu - Frederick MD, US
Ajit Jadhav - Chantilly VA, US
Somnath Jana - Nashville TN, US
Kwangho Kim - Nashville TN, US
Jennifer L. Kouznetsova - Silver Spring MD, US
William J. Moore - Hagerstown MD, US
Bryan T. Mott - College Park MD, US
Leonard M. Neckers - Bethesda MD, US
Anton Simeonov - Bethesda MD, US
Gary Allen Sulikowski - Nashville TN, US
Daniel Jason Urban - Rockville MD, US
Shyh Ming Yang - Doylestown PA, US
International Classification:

C07D 231/20
C07D 403/04
C07D 417/04
C07D 417/14
A61K 31/415
A61K 31/4155
A61K 31/4178
A61K 31/422
A61K 31/427
A61K 31/437
A61K 31/4439
A61K 31/454
A61K 31/496
A61K 31/501
A61K 31/506
A61K 31/519
A61K 31/5355
A61K 45/06
C07D 231/38
C07D 401/04
C07D 403/06
C07D 409/04
C07D 413/04
C07D 471/04
C07D 495/04
C07D 495/14
Abstract:

Provided is a compound of formula (I)in which Ar, R, U, V, W, X, and p are as described herein. Also provided are methods of using a compound of formula (I), including a method of treating cancer, a method of treating a patient with cancer cells resistant to an anti-cancer agent, and a method of inhibiting lactate dehydrogenase A (LDHA) and/or lactate dehydrogenase B (LDHB) activity in a cell.

1 H-Pyrazol-1-Yl-Thiazoles As Inhibitors Of Lactate Dehydrogenase And Methods Of Use Thereof
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US Patent:

20190276448, Sep 12, 2019
Filed:

Jun 29, 2017
Appl. No.:

16/313727
Inventors:

- Bethesda MD, US
- Nashville TN, US
- Birmingham AL, US
- Philadelphia PA, US
Plamen CHRISTOV - Mount Juliet TN, US
Chi V. DANG - Penn Valley PA, US
Victor M. DARLEY-USMAR - Birmingham AL, US
Matthew HALL - Darnestown MD, US
Xin HU - Frederick MD, US
Ajit JADHAV - Chantilly VA, US
Somnath JANA - Nashville TN, US
Kwangho KIM - Nashville TN, US
William J. MOORE - Hagerstown MD, US
Bryan T. MOTT - College Park MD, US
Leonard M. NECKERS - Bethesda MD, US
Anton SIMEONOV - Bethesda MD, US
Gary Allen SULIKOWSKI - Brentwood TN, US
Daniel Jason URBAN - Poolesville MD, US
Shyh Ming YANG - Doylestown PA, US
International Classification:

C07D 417/14
C07D 417/04
A61P 11/00
A61P 35/00
Abstract:

The disclosure provides a compound of the formula (II) and pharmaceutically acceptable salts thereof. The variables, e.g. n, R, R, R, X, Y, and Z are defined herein. These compounds act as lactate dehydrogenase inhibitors and are useful for treating cancer and fibrosis. The compounds may be particularly useful for treating forms of cancer in which a metabolic switch from oxidative phosphorylation to glycolysis has occurred. The disclosure also provides pharmaceutical compositions containing a compound of this formula and method for treating patients having cancer, fibrosis, or other conditions in which a metabolic switch from oxidative phosphorylation to glycolysis has occurred.

Small Molecule Inhibitors Of Lactate Dehydrogenase And Methods Of Use Thereof
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US Patent:

20180273488, Sep 27, 2018
Filed:

Dec 29, 2015
Appl. No.:

15/540893
Inventors:

- Bethesda MD, US
Plamen Christov - Nashville TN, US
Chi V. Dang - Penn Valley PA, US
Victor Darley-Usmar - Brimingham AL, US
Xin Hu - Frederick MD, US
Ajit Jadhav - Chantilly VA, US
Somnath Jana - Nashville TN, US
Kwangho Kim - Nashville TN, US
Jennifer L. Kouznetsova - Silver Spring MD, US
William J. Moore - Hagerstown MD, US
Bryan T. Mott - College Park MD, US
Leonard M. Neckers - Bethesda MD, US
Anton Simeonov - Bethesda MD, US
Gary Allen Sulikowski - Nashville TN, US
Daniel Jason Urban - Rockville MD, US
Shyh Ming Yang - Doylestown PA, US
International Classification:

C07D 231/20
A61K 45/06
C07D 417/04
A61K 31/427
C07D 471/04
A61K 31/437
A61K 31/5355
C07D 417/14
C07D 495/04
A61K 31/519
C07D 403/04
A61K 31/4178
C07D 409/04
A61K 31/4155
A61K 31/4439
A61K 31/415
A61K 31/496
C07D 495/14
A61K 31/501
C07D 231/38
C07D 403/06
C07D 401/04
C07D 413/04
A61K 31/422
A61K 31/506
A61K 31/454
Abstract:

Provided is a compound of formula (I) [Formula (I) should be inserted here], in which Ar, R, U, V, W, X, and p are as described herein. Also provided are methods of using a compound of formula (I), including a method of treating cancer, a method of treating a patient with cancer cells resistant to an anti-cancer agent, and a method of inhibiting lactate dehydrogenase A (LDHA) and/or lactate dehydrogenase B (LDHB) activity in a cell.

Two-Carbon Linked Artemisinin-Derived Trioxane Dimers
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US Patent:

20150361088, Dec 17, 2015
Filed:

Jan 22, 2014
Appl. No.:

14/761699
Inventors:

- Baltimore MD, US
BRYAN T. MOTT - BALTIMORE MD, US
Assignee:

THE JOHNS HOPKINS UNIVERSITY - BALTIMORE MD
International Classification:

C07D 493/18
A61K 45/06
A61K 31/683
A61K 31/4433
C07F 9/655
A61K 31/357
Abstract:

Two-carbon linked artemisinin-derived trioxane dimers and methods of their use for treating subjects infected with malaria or other parasitic infectious diseases including, but not limited to, toxoplasmic infection; subjects afflicted with psychiatric conditions associated with toxoplasmic infection; and subjects afflicted with cancer.