Bruce M Raaka

US Patent:

20090203716, Aug 13, 2009

Filed:

Nov 14, 2008

Appl. No.:

12/291932

Inventors:

Marvin C. Gershengorn - Washington DC, US
Susanne Neumann - Bethesda MD, US
Craig J. Thomas - Gaithersburg MD, US
Holger Jaeschke - Suepitz, DE
Susanna Moore - Rockville MD, US
Gerd Krause - Berlin, DE
Bruce Raaka - Rockville MD, US
Ralf Paschke - Markleeberg, DE
Gunnar Kleinau - Berlin, DE

International Classification:

A61K 31/519
C07D 495/04

US Classification:

5142601, 544278

Abstract:

Disclosed herein are small molecule modulators hormone receptors, including agonists and antagonists of luteinizing hormone/choriogonadotropin, follicle stimulating hormone and thyroid stimulating hormone receptors. Exemplary disclosed compounds include those of the formula

US Patent:

20100286182, Nov 11, 2010

Filed:

Apr 18, 2008

Appl. No.:

12/450922

Inventors:

Herbert H. Samuels - New Rochelle NY, US
Ruben Abagyan - La Jolla CA, US
Matthieu Schapira - Toronto, CA
Maxim Totrov - San Diego CA, US
Bruce M. Raaka - Rockville MD, US
Stephen R. Wilson - Danville VA, US
Li Fan - Cambridge MA, US
Zhiguo Zhou - Winston Salem NC, US

International Classification:

A61K 31/438
A61K 31/4418
C07D 471/10
C07D 211/70
A61P 5/16

US Classification:

514278, 514357, 546 20, 546332

Abstract:

A method of identification of compounds that modulate thyroid hormone activity, and the use of such compounds and compositions thereof for such purposes are disclosed. The compounds may be selected from the group consisting of:The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of conditions that are causally related to aberrant thyroid hormone activity, such as hyperthyroidism and thyrotoxicosis.

US Patent:

20110195018, Aug 11, 2011

Filed:

Oct 20, 2008

Appl. No.:

13/125045

Inventors:

Marvin C. Gershengorn - Washington DC, US
Susanne Neumann - Bethesda MD, US
Bruce M. Raaka - Rockville MD, US
Craig J. Thomas - Gaithersburg MD, US
James Inglese - Bethesda MD, US
Noel T. Southall - Chevy Chase MD, US
Steven Titus - Elkridge MD, US
Wei Zheng - Potomac MD, US
Wenwei Huang - Rockville MD, US
Gerd Krause - Berlin, DE
Gunnar Kleinau - Brelin, DE

International Classification:

A61K 49/00
C07D 239/88
C07D 217/24
A61K 31/47
A61P 35/00
A61K 31/167
A61K 31/517
C07C 233/01

US Classification:

424 111, 544253, 546141, 564221, 424 91, 51426631, 514309, 514625, 424 189

Abstract:

Disclosed are oxo-hydroquinazolines that are useful as selective TSHR agonists. The compounds may be used for detecting or treating thyroid cancer, or treating a bone degenerative disorder.

US Patent:

20130251631, Sep 26, 2013

Filed:

May 17, 2013

Appl. No.:

13/897330

Inventors:

- Berlin-Adlershof, DE
Bruce M. Raaka - Rockville MD, US
Craig J. Thomas - Gaithersburg MD, US
James Inglese - Bethesda MD, US
Noel T. Southall - Chevy Chase MD, US
Steven Titus - Elkridge MD, US
Wei Zheng - Potomac MD, US
Wenwei Huang - Rockville MD, US
Gerd Krause - Berlin, DE
Gunnar Kleinau - Berlin, DE

Assignee:

Forschungsverbund Berlin E.V. - Berlin-Adlershof
The Government of the United States of America as represented by the Secretary of the Department of - Rockville MD

International Classification:

C07D 405/06
A61K 51/00
A61K 31/517

US Classification:

424 161, 544289, 424 91, 51426624

Abstract:

Disclosed are oxo-hydroquinazolines that are useful as selective TSHR agonists. The compounds may be used for detecting or treating thyroid cancer, or treating a bone degenerative disorder.

US Patent:

20160024023, Jan 28, 2016

Filed:

Sep 29, 2015

Appl. No.:

14/869318

Inventors:

- Rockville MD, US
- Berlin-Adlershof, DE
Bruce M. Raaka - Rockville MD, US
Craig J. Thomas - Gaithersburg MD, US
James Inglese - Bethesda MD, US
Noel T. Southall - Chevy Chase MD, US
Steven Titus - Elkridge MD, US
Wei Zheng - Potomac MD, US
Wenwei Huang - Rockville MD, US
Gerd Krause - Berlin, DE
Gunnar Kleinau - Berlin, DE

Assignee:

Health and Human Services - Rockville MD
Forschungsverbund Berlin E.V. - Berlin-Adlershof

International Classification:

C07D 239/91
A61K 31/517
A61K 51/00

Abstract:

Disclosed are oxo-hydroquinazolines that are useful as selective TSHR agonists. The compounds may be used for detecting or treating thyroid cancer, or treating a bone degenerative disorder.