Merck - Kenilworth, NJ Nov 2009 - Dec 2011
Associate Principal Scientist / Medicinal Chemist
Schering-Plough - Kenilworth, NJ 2000 - 2009
Associate Principal Scientist / Medicinal Chemist
Schering-Plough - Kenilworth, NJ 1996 - 2000
Senior Scientist / Medicinal Chemist
Education:
The Scripps Research Institute 1993 - 1996
Post-Doctoral Research Associate, Organic Chemistry
Dartmouth College 1988 - 1993
Ph.D., Organic Chemistry
Bates College 1984 - 1988
BS, Chemistry
Skills:
Organic Chemistry Medicinal Chemistry Drug Discovery Analytical Chemistry Hplc Nmr Lead Optimisation Ip Competitive Int Scientific Writing Technical Presentations Lecturing Gpcrs Kinases Metalloproteases Parallel Synthesis Heterocyclic Chemistry Immunology Drug Design Lead Change Chemistry Drug Development Organic Synthesis Adme Peptides Lc Ms Small Molecules Catalysis Synthetic Organic Chemistry Purification High Performance Liquid Chromatography
Us Patents
Compounds For The Treatment Of Inflammatory Disorders
Zhaoning Zhu - Plainsboro NJ, US Robert Mazzola - Clinton NJ, US Zhuyan Guo - Scotch Plains NJ, US Brian J. Lavey - Chatham NJ, US Lisa Sinning - New Providence NJ, US Joseph Kozlowski - Princeton NJ, US Brian McKittrick - New Vernon NJ, US Neng-Yang Shih - North Caldwell NJ, US
Assignee:
Schering Corporation - Kenilworth NJ
International Classification:
A61K 314709 C07D21514
US Classification:
514311, 514314, 546175
Abstract:
This invention relates to compounds of the Formula (I): or a pharmaceutically acceptable salt, solvate or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, TNF-α or combinations thereof.
Compounds For The Treatment Of Inflammatory Disorders
Zhaoning Zhu - Plainsboro NJ, US Robert Mazzola - Clinton NJ, US Zhuyan Guo - Scotch Plains NJ, US Brian J. Lavey - Chatham NJ, US Lisa Sinning - New Providence NJ, US Joseph Kozlowski - Princeton NJ, US Brian McKittrick - New Vernon NJ, US Neng-Yang Shih - North Caldwell NJ, US
Assignee:
Schering Corporation - Kenilworth NJ
International Classification:
A61K 31/165 A61K 31/18 A61K 31/21 A61K 31/27
US Classification:
514624, 514601, 514513, 514484
Abstract:
This invention relates to compounds of the Formula (I): or a pharmaceutically acceptable salt, solvate or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, TNF-α or combinations thereof.
Joseph A. Kozlowski - Princeton NJ, US Neng-Yang Shih - North Caldwell NJ, US Brian J. Lavey - Chatham NJ, US Razia K. Rizvi - Bloomfield NJ, US Bandarpalle B. Shankar - Branchburg NJ, US James M. Spitler - Westfield NJ, US Ling Tong - Warren NJ, US Ronald L. Wolin - San Diego CA, US Michael K. Wong - North Brunswick NJ, US
Richard J. Friary - Florence MT, US Joseph A. Kozlowski - Princeton NJ, US Bandarpalle B. Shankar - Branchburg NJ, US Michael K. C. Wong - North Brunswick NJ, US Guowei Zhou - Livingston NJ, US Brian J. Lavey - Chatham NJ, US Neng-Yang Shih - North Caldwell NJ, US Ling Tong - Warren NJ, US Lei Chen - Roselle Park NJ, US Youheng Shu - Blue Bell PA, US
Assignee:
Schering Corporation - Kenilworth NJ
International Classification:
A61K 31/445 C07D 401/12
US Classification:
514323, 546201
Abstract:
There are disclosed compounds of the formula I: or a pharmaceutically acceptable salt of the compound, which exhibit anti-inflammatory and immunomodulatory activity. Also disclosed are pharmaceutical compositions containing said compounds.
Compounds For The Treatment Of Inflammatory Disorders
Wensheng Yu - Edison NJ, US Ling Tong - Warren NJ, US Lei Chen - Roselle Park NJ, US Joseph A. Kozlowski - Princeton NJ, US Brian J. Lavey - New Providence NJ, US Neng-Yang Shih - Warren NJ, US Vincent S. Madison - Mountain Lakes NJ, US Guowei Zhou - Livingston NJ, US Peter Orth - New York NY, US Zhuyan Guo - Scotch Plains NJ, US Michael K. C. Wong - North Brunswick NJ, US De-Yi Yang - Morris Plains NJ, US Seong Heon Kim - Livingston NJ, US Bandarpalle B. Shankar - Branchburg NJ, US
Wensheng Yu - Edison NJ, US Ling Tong - Warren NJ, US Lei Chen - Roselle Park NJ, US Joseph A. Kozlowski - Princeton NJ, US Brian J. Lavey - New Providence NJ, US Neng-Yang Shih - Warren NJ, US Vincent S. Madison - Mountain Lakes NJ, US Guowei Zhou - Livingston NJ, US Peter Orth - New York NY, US Zhuyan Guo - Scotch Plains NJ, US Michael K. C. Wong - North Brunswick NJ, US De-Yi Yang - Morris Plains NJ, US Seong Heon Kim - Livingston NJ, US Bandarpalle B. Shankar - Branchburg NJ, US M. Arshad Siddiqui - Newton MA, US Kristin E. Rosner - Watertown MA, US Chaoyang Dai - Acton MA, US Janeta Popovici-Muller - Waltham MA, US Vinay M. Girijavallabhan - Watertown MA, US Dansu Li - Watertown MA, US Razia Rizvi - Bloomfield NJ, US Aneta M. Micula - South Amboy NJ, US Robert Feltz - Parsippany NJ, US
Wensheng Yu - Edison NJ, US Ling Tong - Warren NJ, US Lei Chen - Roselle Park NJ, US Joseph A. Kozlowski - Princeton NJ, US Brian J. Lavey - New Providence NJ, US Neng-Yang Shih - Warren NJ, US Vincent S. Madison - Mountain Lakes NJ, US Guowei Zhou - Livingston NJ, US Peter Orth - New York NY, US Zhuyan Guo - Scotch Plains NJ, US Michael K. C. Wong - North Brunswick NJ, US De-Yi Yang - Morris Plains NJ, US Seong Heon Kim - Livingston NJ, US Bandarpalle B. Shankar - Branchburg NJ, US M. Arshad Siddiqui - Newton MA, US Kristin E. Rosner - Watertown MA, US Chaoyang Dai - Acton MA, US Umar Faruk Mansoor - Framingham MA, US Janeta Popovici-Muller - Waltham MA, US Vinay M. Girijavallabhan - Watertown MA, US Dansu Li - Watertown MA, US
Joseph A. Kozlowski - Princeton NJ, US Neng-Yang Shih - North Caldwell NJ, US Brian J. Lavey - Chatham NJ, US Razia K. Rizvi - Bloomfield NJ, US Bandarpalle B. Shankar - Branchburg NJ, US James M. Spitler - Westfield NJ, US Ling Tong - Warren NJ, US Ronald L. Wolin - San Diego CA, US Michael K. Wong - North Brunswick NJ, US
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