John C. Reed - Rancho Santa Fe CA, US Bin Guo - Fargo ND, US Bingzhen Lin - La Jolla CA, US Siva Kumar Kolluri - San Diego CA, US
Assignee:
The Burnham Institute - La Jolla CA
International Classification:
A61K 38/00 G01N 33/53 A61K 1/00
US Classification:
530300, 435 71, 530350
Abstract:
Compounds that modulate the function of anti-apoptotic proteins such as Bcl-2 and Bcl-Xare identified. These compounds have the ability to convert the activity of Bcl-2-family member proteins from anti-apoptotic to pro-apoptotic. Methods for inducing apoptosis are described, together with methods for identifying molecules that induce apoptosis through interaction with Bcl-2-family members.
Compounds that modulate the function of anti-apoptotic proteins such as Bcl-2 and Bcl-Xare identified. These compounds have the ability to convert the activity of Bcl-2-family member proteins from anti-apoptotic to pro-apoptotic. Methods for inducing apoptosis are described, together with methods for identifying molecules that induce apoptosis through interaction with Bcl-2-family members.
Compounds that modulate the function of anti-apoptotic proteins such as Bcl-2 and Bcl-Xare identified. These compounds have the ability to convert the activity of Bcl-2-family member proteins from anti-apoptotic to pro-apoptotic. Methods for inducing apoptosis are described, together with methods for identifying molecules that induce apoptosis through interaction with Bcl-2-family members.
John Reed - Rancho Santa Fe CA, US Bin Guo - Fargo ND, US Bingzhen Lin - La Jolla CA, US Siva Kolluri - San Diego CA, US
International Classification:
A61K039/395 A61K038/17
US Classification:
514/012000, 530/350000, 424/155100, 530/388800
Abstract:
Compounds that modulate the function of anti-apoptotic proteins such as Bcl-2 and Bcl-Xare identified. These compounds have the ability to convert the activity of Bcl-2-family member proteins from anti-apoptotic to pro-apoptotic. Methods for inducing apoptosis are described, together with methods for identifying molecules that induce apoptosis through interaction with Bcl-2-family members.