Bhasker R Aavula

age ~60

from Pleasanton, CA

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Also known as:

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Soluble Epoxide Hydrolase Inhibitors
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US Patent:

20090270382, Oct 29, 2009
Filed:

Apr 17, 2009
Appl. No.:

12/426136
Inventors:

Bhasker R. Aavula - Pleasanton CA, US
International Classification:

A61K 31/5365
C07D 213/02
A61K 31/4545
C12N 9/99
C07D 413/14
A61K 31/5377
C07D 498/02
A61P 9/12
A61P 29/00
A61P 11/00
A61P 3/10
US Classification:

5142305, 546194, 514318, 435184, 544129, 5142355, 544105
Abstract:

Disclosed are amide, thioamide, urea and thiourea compounds and compositions that inhibit soluble epoxide hydrolase (sEH), methods for preparing the compounds and compositions, and methods for treating patients with such compounds and compositions. The compounds, compositions, and methods are useful for treating a variety of sEH mediated diseases, including hypertensive, cardiovascular, inflammatory, and diabetic-related diseases.

Pyrrolopyrimidinyl Axl Kinase Inhibitors
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US Patent:

20100204221, Aug 12, 2010
Filed:

Feb 8, 2010
Appl. No.:

12/658433
Inventors:

Hariprasad Vankayalapati - Draper UT, US
Xiao-Hui Liu - Sandy UT, US
William Merton Hewitt - Salt Lake City UT, US
Eric Scott Gourley - Taylorsville UT, US
Yong Xu - Midvale UT, US
Bhasker Aavula - Pleasanton CA, US
International Classification:

A61K 31/5377
C07D 487/04
A61K 31/519
C07D 413/14
C07D 495/04
A61P 35/00
US Classification:

5142342, 544280, 5142651, 51425216, 544117, 544278
Abstract:

Compounds represented by Formula (I):are useful in treating diseases, such as cancer, that are mediated and/or associated (at least in part) with Axl kinase. The compounds can be formulated as pharmaceutically acceptable compositions for administration to a subject in need thereof.

Soluble Epoxide Hydrolase Inhibitors For The Treatment Of Endothelial Dysfunction
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US Patent:

20090247521, Oct 1, 2009
Filed:

Dec 23, 2008
Appl. No.:

12/343358
Inventors:

Bhasker R. Aavula - Pleasanton CA, US
Dinesh Patel - Fremont CA, US
Gabor Rubanyi - San Diego CA, US
Yi-Xin Wang - Lafayette CA, US
Heather K. Webb Hsu - Seattle WA, US
International Classification:

A61K 31/445
A61K 31/17
A61K 31/215
A61K 31/19
A61K 31/5377
A61K 31/4545
A61K 31/454
A61K 31/4709
A61P 9/00
US Classification:

5142355, 514588, 514511, 514557, 514329, 514318, 514326, 514314
Abstract:

The present invention generally relates to methods useful for a therapy using a class of urea or amide compounds and related compositions, wherein the compound is a soluble epoxide hydrolase inhibitor, for treating and ameliorating the symptoms of diseases related to endothelial dysfunction.