Arvydas A Usas

US Patent:

20100215623, Aug 26, 2010

Filed:

Aug 18, 2009

Appl. No.:

12/543311

Inventors:

Arvydas Usas - Pittsburgh PA, US
Karin Payne - Pittsburgh PA, US
Thomas Payne - Pittsburgh PA, US
Ronald Jankowski - Pittsburgh PA, US
Johnny Huard - Waxford PA, US

International Classification:

A61K 35/34
A61K 35/32
A61P 19/08

US Classification:

424 937

Abstract:

The present invention provides muscle-derived progenitor cells that show long-term survival following transplantation into body tissues and which can augment non-soft tissue following introduction (e.g. via injection, transplantation, or implantation) into a site of non-soft tissue (e.g. bone) when combined with a biocompatible matrix, preferably SIS. The invention further provides methods of using compositions comprising muscle-derived progenitor cells with a biocompatible matrix for the augmentation and bulking of mammalian, including human, bone tissues in the treatment of various functional conditions, including osteoporosis, Paget's Disease, osteogenesis imperfecta, bone fracture, osteomalacia, decrease in bone trabecular strength, decrease in bone cortical strength and decrease in bone density with old age.