Anthony F Purchio from 4966 Par Three Ln, Salt Lake City, UT 84107, age 76, Phone: 8015908453

Clonal Cells And Cell Lines Derived From C3A Cells And Methods Of Making And Using Them
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US Patent:

6653105, Nov 25, 2003
Filed:

Feb 11, 1998
Appl. No.:

09/022469
Inventors:

Dennis Triglia - San Diego CA
Anthony Purchio - Solana Beach CA
Assignee:

Vitagen, Inc. - La Jolla CA
International Classification:

C12P 2104
US Classification:

435 701, 435325, 435370, 435455, 424 9321
Abstract:

A serum-free C3A clonal cell line and methods for generating the same are provided. The C3A cell line has a reduced doubling time in serum-free medium compared to a corresponding C3A cell line from which it is derived. Methods using the cells of the serum-free C3A clonal cell line for the production, expression and recovery of harvestable polypeptides, screening compounds for metabolic activity, studying enteric disease and for use in a bio-artificial liver device are also provided.

Methods And Compositions For Screening For Angiogenesis Modulating Compounds
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US Patent:

6867348, Mar 15, 2005
Filed:

Dec 16, 1999
Appl. No.:

09/465978
Inventors:

Ning Zhang - Alameda CA, US
Anthony F. Purchio - Alameda CA, US
Assignee:

Xenogen Corporation - Alameda CA
International Classification:

A01K067/027
C12N015/63
US Classification:

800 18, 4353201
Abstract:

The present invention relates to novel promoters, including transcription regulator regions, for the mouse VEGFR-2 receptor, isolated polynucleotides comprising such promoters, nucleic acid constructs comprising such promoters operatively linked to genes encoding a gene product, such as, a reporter, a protein, polypeptide, hormone, ribozyme, or antisense RNA, recombinant cells comprising such nucleic acid constructs, screening for therapeutic drugs using such cells (e. g. , screening for compounds that modulate VEGFR-2-mediated angiogenesis), and endothelial tissue-specific gene expression using these novel promoter sequences.

Compositions And Methods For Use Thereof In Modifying The Genomes Of Microorganisms
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US Patent:

7056728, Jun 6, 2006
Filed:

Jun 21, 2001
Appl. No.:

09/888049
Inventors:

Kevin P. Francis - Alameda CA, US
Anthony F. Purchio - Alameda CA, US
Assignee:

Xenogen Corporation - Alameda CA
International Classification:

C12N 15/00
C12N 15/01
C12N 15/74
US Classification:

4353201, 435 4, 435 6, 435440, 435471, 435473, 435477, 435243, 4352523, 536 231, 536 241
Abstract:

The present invention relates to bacterial luciferase transposon cassettes suitable for conferring bioluminescence properties on a Gram-positive bacteria, Gram-negative bacteria, and other organisms of interest. The invention further includes cells transformed with vectors carrying the transposon cassettes, cells whose genomes have been modified by introduction of such cassettes, and methods of making and using such transposon cassettes, transposon cassette vectors, and cells containing the transposons.

Methods And Compositions For Screening For Angiogenesis Modulating Compounds
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US Patent:

7196190, Mar 27, 2007
Filed:

Dec 15, 2000
Appl. No.:

09/738968
Inventors:

Zhang Ning - Alameda CA, US
Pamela Reilly Contag - San Jose CA, US
Anthony F. Purchio - Alameda CA, US
Assignee:

Xenogen Corporation - Alameda CA
International Classification:

C07H 21/04
C12N 15/00
C12N 15/63
C12N 5/00
A01K 67/027
US Classification:

536 241, 4353201, 435325
Abstract:

The present invention relates to novel transcription control elements, including promoters, derived from angiogenesis-related genes, particularly the mouse VEGF gene, the mouse VEGFR-2 receptor gene, and the mouse Tie2 gene. Also disclosed are isolated polynucleotides comprising such promoters, as well as nucleic acid constructs comprising such promoters operatively linked to genes encoding a gene product, such as, a reporter, a protein, polypeptide, hormone, ribozyme, or antisense RNA, and to recombinant cells and transgenic animals comprising such nucleic acid constructs. The present invention further relates to screening methods using those recombinant cells and transgenic animals, particularly methods of screening for therapeutic compounds that modulate tumorigenesis and angiogenesis.

C3A Serum-Free Clonal Cell Line And Methods Of Use
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US Patent:

7390651, Jun 24, 2008
Filed:

Nov 25, 2003
Appl. No.:

10/723590
Inventors:

Dennis Triglia - San Diego CA, US
Anthony Purchio - Solana Beach CA, US
Assignee:

Vital Therapies, Inc. - San Diego CA
International Classification:

C12M 1/00
C12M 3/00
C12N 5/00
C12N 5/08
US Classification:

4352891, 4352831, 4352904, 435325, 435370
Abstract:

A serum-free C3A clonal cell line and methods for generating the same are provided. The C3A cell line has a reduced doubling time in serum-free medium compared to a corresponding C3A cell line from which it is derived. Methods using the cells of the serum-free C3A clonal cell line for the production, expression and recovery of harvestable polypeptides, screening compounds for metabolic activity, studying enteric disease and for use in a bio-artificial liver device are also provided.

Isolation And Identification Of Mouse And Human Transcription Control Elements Associated With Cytochrome Expression
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US Patent:

7449567, Nov 11, 2008
Filed:

Apr 11, 2002
Appl. No.:

10/121960
Inventors:

Weisheng Zhang - Fremont CA, US
Pamela Contag - San Jose CA, US
Anthony Purchio - Alameda CA, US
Sandy Hashima - San Diego CA, US
Shirley Ma - Fremont CA, US
Kevin Nawotka - Alameda CA, US
Assignee:

Xenogen Corporation - Alameda CA
International Classification:

C07H 21/04
C07H 21/02
G01N 33/00
G01N 33/567
C12N 5/06
C12N 5/10
US Classification:

536 241, 536 231, 800 3, 435354, 435 721
Abstract:

The present invention relates to transcription control elements derived from mouse and human genes associated with cytochrome expression, e. g. , Cyp3A11 and CYP3A4, respectively. Isolated polynucleotides, expression cassettes, vectors, recombinant cells, and transgenic animals, may comprise such transcription control elements as described herein.

Methods And Compositions For Imaging Atherosclerotic Plaques
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US Patent:

8467493, Jun 18, 2013
Filed:

Jan 8, 2010
Appl. No.:

12/684793
Inventors:

Anthony F. Purchio - Taylorsville UT, US
Ali Bahadur - South Jordan UT, US
Sergio Vasquez - South Jordan UT, US
Assignee:

Numira Biosciences, Inc. - Salt Lake City UT
International Classification:

G01N 23/00
G06K 9/00
US Classification:

378 4, 382131
Abstract:

The present invention relates in general to compositions, processes and apparatus for imaging, and in particular for preparation, collection and processing of images of atherosclerotic plaques, including images obtained from X-ray microscopic computed tomography.

Nucleic Acids Encoding Novel Serine Protease Inhibitor Proteins Associated With The Liver And Methods Of Making And Using Them
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US Patent:

20020142986, Oct 3, 2002
Filed:

Jan 31, 2002
Appl. No.:

10/062023
Inventors:

Anthony Purchio - Cardiff CA, US
Assignee:

Hepatix, Inc., a California corporation
International Classification:

A61K048/00
A61K038/17
C07H021/04
C12P021/02
C12N005/06
C12N009/99
US Classification:

514/044000, 514/012000, 435/069200, 435/184000, 435/320100, 435/325000, 536/023200
Abstract:

The invention provides human regeneration-associated serpin-1 (RASP-1) polypeptide and nucleic acid molecules that encode RASP-1. Also included in the invention are diagnostic and therapeutic methods using RASP-1 polypeptides and nucleic acids.