Anna Borodovsky from 14 Oakland St APT 1, Melrose, MA 02176, age 48, Phone: 6176422776

Compositions And Methods For Inhibiting Expression Of A Gene From The Ebola Virus
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US Patent:

7973020, Jul 5, 2011
Filed:

May 27, 2010
Appl. No.:

12/789414
Inventors:

Sina Bavari - Frederick MD, US
Kelly Lyn Warfield - Adamstown MD, US
Pamela Tan - Kulmbach, DE
Anna Borodovsky - Cambridge MA, US
Tatiana Novobrantseva - Wellesley MA, US
Antonin de Fougerolles - Brookline MA, US
Assignee:

Alnylam Pharmaceuticals, Inc. - Cambridge MA
The United States of America as represented by the Secretary of the Army - Washington DC
International Classification:

C07H 21/02
C07H 21/04
A61K 31/70
US Classification:

514 44, 536 231, 536 243, 536 2433, 536 245
Abstract:

The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of a gene from the Ebola virus.

Compositions And Methods For Inhibiting Expression Of Cd45 Gene
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US Patent:

8288525, Oct 16, 2012
Filed:

Feb 12, 2009
Appl. No.:

12/867230
Inventors:

Antonin de Fougerolles - Brookline MA, US
Pamela Tan - Kulmbach, DE
Anna Borodovsky - Cambridge MA, US
Tatiana Novobrantseva - Wellesley MA, US
Sina Bavari - Frederick MD, US
Kelly Lyn Warfield - Adamstown MD, US
Assignee:

Alnylam Pharmaceuticals, Inc. - Cambridge MA
International Classification:

C12Q 1/68
US Classification:

536 245, 536 241, 536 2431, 514 44, 435 6, 435325, 435375
Abstract:

The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of the CD45 gene.

Compositions And Methods For Inhibiting Expression Of A Gene From The Ebola Virus
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US Patent:

8354390, Jan 15, 2013
Filed:

Apr 25, 2011
Appl. No.:

13/093681
Inventors:

Sina Bavari - Frederick MD, US
Kelly Lyn Warfield - Adamstown MD, US
Pamela Tan - Kulmbach, DE
Anna Borodovsky - Cambridge MA, US
Tatiana Novobrantseva - Wellesley MA, US
Antonin de Fougerolles - Brookline MA, US
Assignee:

Alnylam Pharmaceuticals, Inc. - Cambridge MA
The United States of America, as represented by the Secretary of the Army - Washington DC
International Classification:

A61K 31/70
C07H 21/02
C07H 21/04
US Classification:

514 44A, 536 241, 536 245
Abstract:

The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of a gene from the Ebola virus.

Semisynthetic Protein-Based Site-Directed Probes For Identification And Inhibition Of Active Sites, And Methods Therefor
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US Patent:

20050277762, Dec 15, 2005
Filed:

Apr 25, 2003
Appl. No.:

10/423421
Inventors:

Hidde Ploegh - Brookline MA, US
Huib Ovaa - Boston MA, US
Anna Borodovsky - Somerville MA, US
Benedikt Kessler - Cambridge MA, US
Joris Hemelaar - Boston MA, US
Paul Galardy - North Andover MA, US
Nagamalleswari Kolli - Doraville GA, US
Keith Wilkinson - Lilburn GA, US
International Classification:

C07K014/00
US Classification:

530350000
Abstract:

A C-terminally modified Ubiquitin (Ub) derivative) ubiquitin vinyl sulfone (UbVS), which is specific for deubiquitinating enzymes (DUBs), was synthesized as an active site directed probe that irreversibly modifies a subset of Ub C-terminal hydrolases (UCHs) and Ub specific processing proteases (UBPs), is provided. [I]-UbVS modifies 6 of the 17 known and putative yeast deubiquitinating enzymes, namely Yuh1p, Ubp1p, Ubp2p, Ubp6p, Ubp12p and Ubp15p. In mammalian cells, a greater number of polypeptides is labeled, most of which are DUBs. An additional DUB that associates with the mammalian 26S proteasome, novel protein USP14, a mammalian homolog of yeast Ubp6p that is bound to the proteasome, is provided.

Compositions And Methods For Inhibiting Expression Of A Gene From The Ebola
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US Patent:

20090143323, Jun 4, 2009
Filed:

Mar 25, 2008
Appl. No.:

12/055295
Inventors:

Sina Bavari - Frederick MD, US
Kelly Lyn Warfield - Adamstown MD, US
Pamela Tan - Kulmbach, DE
Anna Borodovsky - Cambridge MA, US
Tatiana Novobrantseva - Wellesley MA, US
Antonin de Fougerolles - Brookline MA, US
Assignee:

ALNYLAM PHARMACEUTICALS, INC. - Cambridge MA
GOVERNMENT OF THE UNITED STATES - Frederick MD
International Classification:

A61K 31/713
C07H 21/02
C12N 5/06
C12N 15/63
C12N 5/10
US Classification:

514 44, 536 245, 435325, 435375, 4353201
Abstract:

The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of a gene from the Ebola virus.

Liver Screening Method
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US Patent:

20110045473, Feb 24, 2011
Filed:

Dec 31, 2008
Appl. No.:

12/811511
Inventors:

Antonin De Fougerolles - Brookline MA, US
Tatiana Novobrantseva - Wellesley MA, US
Anna Borodovsky - Cambridge MA, US
Akin Akinc - Needham MA, US
Mark Tracy - Cambridge MA, US
International Classification:

C12Q 1/68
C12Q 1/37
G01N 33/53
US Classification:

435 6, 435 23, 436 94
Abstract:

The invention features a method of identifying therapeutically relevant compositions that include a therapeutic agent and a delivery component by screening for an effect of the agent on the liver of a model subject.

Screening Method For Selected Amino Lipid-Containing Compositions
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US Patent:

20110097720, Apr 28, 2011
Filed:

Dec 31, 2008
Appl. No.:

12/811503
Inventors:

Marco A. Ciufolini - Vancouver, CA
Thomas D. Madden - Vancouver, CA
Michael J. Hope - Vancouver, CA
Barbara Mui - Vancouver, CA
De Fougerolles Antonin - Brookline MA, US
Tatiana Novobrantseva - Wellesley MA, US
Anna Borodovsky - Cambridge MA, US
Akin Akinc - Needham MA, US
Mark Tracy - Cambridge MA, US
Pieter Rutter Cullis - Vancouver, CA
Assignee:

ALNYLAM PHARMACEUTICALS, INC. - Cambridge MA
International Classification:

C12Q 1/68
C12Q 1/02
US Classification:

435 6, 435 29
Abstract:

The invention features a method of identifying therapeutically relevant compositions which include a therapeutic agent and 2,2-Dilinoley 1-4-dimethylaminomethyl-[1,3]-dioxolane by screening for an effect of the agent on the liver of a model subject.

Phosphorothioate Oligonucleotides And Non-Nucleosidic Phosphorothioates As Delivery Agents For Irna Agents
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US Patent:

20110218334, Sep 8, 2011
Filed:

Jul 10, 2009
Appl. No.:

13/003355
Inventors:

Martin Maier - Cambridge MA, US
Muthiah Manoharan - Cambridge MA, US
Kevin Fitzgerald - Cambridge MA, US
Antonin de Fougerolles - Cambridge MA, US
Tatiane Novobrantseva - Cambridge MA, US
Anna Borodovsky - Cambridge MA, US
Assignee:

ALNYLAM PHARMACEUTICALS, INC. - Cambridge MA
International Classification:

C07H 21/02
US Classification:

536 245
Abstract:

The invention relates to use of single-stranded phosphorothioate oligonucleotides or non-nucleosidic phosphrothiaote as vehicles or carriers to modulate the biodistribution of iRNA agents.

Anna Borodovsky